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Limited Submission: Continuation of the Human Pancreas Analysis Program (HPAP) for Type 1 Diabetes (HPAP-T1D) (U01 Clinical Trial Not Allowed)

This FOA will support one team of investigators with combined expertise in human pancreas physiology and pathophysiology; collection, processing and multimodal analysis of human pancreatic tissues; and biological database building, curation and management.

Summary

This Funding Opportunity Announcement (FOA) invites a single cooperative agreement application to continue the mission of the existing Human Pancreas Analysis Program (HPAP). This FOA will support one team of investigators with combined expertise in human pancreas physiology and pathophysiology; collection, processing and multimodal analysis of human pancreatic tissues; and biological database building, curation and management, that will be tasked to: 1) identify, collect and intensively characterize primary pancreatic tissues from patients with type 1 diabetes (T1D) or at risk of developing the disease, as well as age-matched controls; and 2) analyze, organize and share the data resulting from the study of these tissues through the existing PANC DB open-access resource database. HPAP is a component of the Human Islet Research Network or HIRN. HIRN was created in 2014 to support innovative and collaborative translational research to understand how human beta cells are lost in T1D, and to find innovative strategies to protect and replace functional human beta cell mass.

Please read the full program announcement before preparing your internal application.

Award Amount

  • The application budget is limited to $4.5 million in direct costs per year [excluding subcontract Facilities and Administrative (F&A)costs].
  • The maximum project period is 4 years.
  • NIDDK intends to commit $7 million in FY 2020 to fund 1 award.

Eligibility

  • Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with his/her organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support.

Selection Criteria

  • Detailed selection criteria can be found here.

Limitation Details

An Institution may submit one proposal.

If you are interested in submitting for this program, you must first submit an internal application to limsub@uga.edu according to the required instructions below.

Internal Applications must include the following:

  • A cover page listing
    • The name of this funding opportunity and title of your proposal
    • Your name, UGA position, home department, email, and UGA contact information
    • Collaborator names, positions, and institutions (if any)
    • Indicate whether or not you have submitted to this program in the past. If so, please provide a copy of the review at the end of the internal application.
  • A (maximum two-page) proposal summary that addresses the program’s specific selection criteria.
  • One paragraph describing why this proposal should be UGA’s submission (i.e., why it will be the most competitive for this program)
  • Curriculum vitae

Internal Selection

Limited Submission announcements often generate multiple competing proposals.  UGA reviewers judge proposals as they would in any peer review process, so PIs are urged to put their best foot forward.  Along with typical criteria, reviewers will evaluate internal proposals based on their fit with the sponsor’s articulated goals and criteria.

Internal Submission Instructions

The above internal application materials should be submitted via email as a single .PDF file to limsub@uga.edu by the internal deadline listed above.

Questions?

Please submit questions regarding the internal competition to limsub@uga.edu.

For questions directly related to this program, please contact the following program officers:

Xujing Wang
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Telephone: 301-451-2862
Email: xujing.wang@nih.gov

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