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Awards & Honors Find Funding Large Grant Opportunities

This program supports formal education by strengthening the teaching and study of the humanities at institutions of higher education. For 2026, projects must be focused on Western civilization, American history, American government and civics, and/or the Great Books tradition.

Amount: $750,000

Due Date: 06/25/2026

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Awards & Honors Find Funding Large Grant Opportunities

This program will fund P50 SPORE grants to support state-of-the-art investigator-initiated translational research that will contribute to improved prevention, early detection, diagnosis, and treatment of an organ-specific cancer or a highly related group of cancers. For the purpose of this NOFO, a group of highly related cancers are those that are derived from the same organ system, such as gastrointestinal, neuroendocrine, head and neck, and other cancers.

Amount: $10,570,000

Due Date: 08/25/2026 (LOI); 09/25/2026 (Full Proposal)

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Awards & Honors Find Funding Large Grant Opportunities

The purpose of this program is to support the development, production, and distribution of radio programs, podcasts, and documentary films that engage general audiences with humanities ideas in creative and appealing ways.

Amount: Up to $75,000 (Development); Up to $700,000 (Production)

Due Date: 06/25/2026

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Announcements Find Funding Large Grant Opportunities

The goal of this program is to advance the preservation and availability of physical and digital collections important for research, teaching, and public engagement in the humanities.

Amount: $50,000 – $500,000

Due Date: 05/11/2026; 12/15/2026

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Announcements Find Funding Large Grant Opportunities

The Department of State invites eligible applicants to advance the America First Global Health Strategy through its new Advancing Global Health (AGH) program, which aims to save lives, strengthen health systems, enhance efficiency, foster self-reliance, and ensure U.S. investments benefit American safety, strength, and prosperity.

Amount: $500,000 – $250,000,000

Due Date: 05/31/2026 (Window 1); 11/14/2026 (Window 2); 02/14/2027 (Window 3)

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Announcements Find Funding Large Grant Opportunities

This program leverages the NICHD clinical research network infrastructure relevant to infants, children, women, and persons with disabilities to conduct innovative, multisite, investigator-initiated clinical trials and observational studies.

Amount: $6,250,000

Due Date: 07/15/2026

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Announcements Find Funding Large Grant Opportunities

This NOFO invites applications for centers to support transdisciplinary teams to engage in high-impact studies that will significantly advance clinical practice and generate knowledge that will fuel transformation of mental health care in the United States.

Amount: $11,325,000

Due Date: 04/18/2026 (LOI); 05/18/2026 (Full Proposal)

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Announcements Find Funding Large Grant Opportunities

This program supports the design and implementation of research infrastructure — including equipment, cyberinfrastructure, large-scale datasets and personnel — whose total project costs are under $20 million.

Amount: $4,000,000 – $19,999,999

Due Date: 09/01/2026 (Pre-Proposals); 02/08/2027 (Full Proposals)

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Announcements Find Funding Large Grant Opportunities

This program aims to support the establishment or continuation of longitudinal infant cohorts to determine and compare how initial and repeated natural influenza infections and/or influenza vaccinations shape infant and childhood immunity to future influenza exposures. The goal is to understand how these exposures influence immune responses to subsequent influenza infections and/or vaccines and provide key information to facilitate design of durable, broadly protective influenza vaccines.

Amount: $22,650,000

Due Date: 06/04/2026

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Announcements Find Funding Large Grant Opportunities

This Notice of Funding Opportunity (NOFO) is for support of National Centers for Cryoelectron Tomography (CryoET) to provide nationwide access to advanced cryoET instrumentation and technical support, and to assist investigators in acquiring the skills needed to perform cryoET studies.

Amount: Unspecified

Due Date: 01/26/2027

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