Category: Large Grant Opportunities

This initiative seeks regional consortia to accelerate, expand, and improve microelectronics talent development across the United States through industry-aligned education, workforce pathways, hands-on training, and digital resource sharing. It aims to modernize education infrastructure, expand teaching capacity, and strengthen U.S. competitiveness in semiconductor industries while fostering a robust domestic talent pipeline.

Amount: $5,000,000

Due Date: 12/22/2025

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Supports marine conservation to address climate impacts and biodiversity loss; performing arts with a focus on classical music and theater; and social equity programs fostering safe, thriving communities for underrepresented groups, emphasizing long-term, community-led solutions. Amount: Typically $5,000 – $1,000,000

Due Date: 12/19/2025 (LOIs for Social Impact Grants); 01/30/2026 (Full Applications)

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This program is intended to support education research projects that engage in collaborative and participatory partnerships.

Amount: $400,000

Due Date: 11/14/2025 (Pre-Proposals)

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This program invites applications for centers to support transdisciplinary teams of clinical and mental health services researchers, behavioral scientists, social scientists, health information and communications technologists, health systems engineers, decision scientists, and mental health stakeholders to engage in high-impact studies that will significantly advance clinical practice and generate knowledge that will fuel transformation of mental health care in the United States.

Amount: $11,325,000

Due Date: 05/18/2026

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This program provides long-term, flexible funding to mid-career scientists, giving them the freedom to pursue high-risk, high-reward research at the leading edge of cancer immunotherapy.

Amount: $1,250,000

Due Date: 01/15/2026

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This program aims to accelerate biomanufacturing equipment and process innovation, digital transformation, next generation therapies, and commercial adoption all at once focused on accelerating innovation in the manufacture, testing, and release of RNA-containing modalities.

Amount: Unspecified

Due Date: 12/19/2025 (Solution Summaries); 02/27/2026 (Full Proposals)

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This funding opportunity will support watershed restoration and vegetation management projects on National Forest System lands to achieve a healthy forest ecosystem. Applicants should develop proposals that increase forest management activities and reduce wildfire risk to ultimately promote healthy forests, increase timber productivity and protect American prosperity.

Amount: $250,000 – $2,000,000

Due Date: 01/13/2026

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This program supports either design or implementation of unique and compelling Research Infrastructure projects. Mid-scale implementation projects may include any combination of equipment, instrumentation, cyberinfrastructure, broadly used large scale datasets and the personnel needed to successfully commission the project.

Amount: $400,000 – $20M

Due Date: 09/01/2026 (Pre-Proposal); 02/08/2027 (Full Proposal)

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The NIDCD invites applications for Clinical Research Center Grants designed to advance the diagnosis, prevention, treatment, and amelioration of human sensory and communication disorders. For this announcement, Clinical Research is defined as research involving individuals with a sensory and/or communication disorder, or data/tissues from individuals with a sensory and/or communication disorder.

Amount: $11,325,000

Due Date: 11/04/2025; 02/02/2026

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This program supports research on the discovery and development of interventions to prevent and/or treat substance use disorders (SUDs) and overdose, including interventions to treat co-morbid SUDs. This includes preclinical and clinical research studies that will have high impact and quickly yield the necessary results to advance candidate interventions closer to regulatory approval or clinical adoption.

Amount: $22,650,000

Due Date: 10/20/2025; 02/20/2026

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