Category: Large Grant Opportunities

The purpose of this NOFO is to catalyze the translation of Artificial Intelligence (AI)-enabled, image-centered, multimodal CDS tools, developed as Software as a Medical Device, from training and testing of prototypes towards clinical applications that address unmet health challenges in precision medicine. These projects are expected to have high potential for demonstrable, positive impact on patient outcomes and/or healthcare processes.

Amount: $5,928,000

Due Date: 10/19/2026

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The purpose of this NOFO is to solicit applications for the creation of a Validation Center to serve as a dedicated hub for the comprehensive evaluation and characterization of AI-enabled, image-based, multimodal clinical decision support tools developed by the PRIMED-AI Consortium, to ensure these tools are reliable, reproducible, and generalizable.

Amount: $22,496,000

Due Date: 10/02/2026

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The purpose of this program supports collaborative teams who edit, annotate, and translate foundational humanities texts that are vital to generating new scholarship but are not available in adequate editions or translations. This year’s competition is limited to projects on American history and culture or Western civilization. Applications must focus on topics in the history and culture of the United States in any period from the Colonial Era to the present, or topics in Western civilization from antiquity to the present.

Amount: $65,000 (Planning); $450,000 (Implementation)

Due Date: 09/16/2026

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The purpose of this NOFO is to catalyze the development and testing of Artificial Intelligence (AI)-enabled, image-centered, multimodal Clinical Decision Support tools, developed in pursuance as Software as a Medical Device. These projects are expected to have high potential for demonstrable, positive impact on patient outcomes and/or healthcare processes.

Amount: $5,016,000

Due Date: 08/24/2026

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This NOFO solicits applications for the continued development and sustainment of high value informatics research resources to improve the acquisition, management, analysis, and dissemination of data and knowledge across the cancer research continuum including cancer biology, cancer treatment and diagnosis, early cancer detection, risk assessment and prevention, cancer control and epidemiology.

Amount: $4,560,000

Due Date: 10/19/2026

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This NOFO solicits applications for the continued development and sustainment of high value informatics research resources to improve the acquisition, management, analysis, and dissemination of data and knowledge across the cancer research continuum including cancer biology, cancer treatment and diagnosis, early cancer detection, risk assessment and prevention, cancer control and epidemiology.

Amount: $4,560,000

Due Date: 10/19/2026

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This program solicits applications for research on developing a comprehensive and cohesive understanding of cancer metastasis. Each MetNet Center should propose an overarching scientific theme that will be pursued through two or three scientific inter- and multidisciplinary basic research projects. Studies on all types of cancer are welcome, including rare and pediatric metastatic cancers. Proposed research is expected to advance our understanding towards a more comprehensive appreciation of metastasis as a whole body, systems-level problem.

Amount: $9,880,000

Due Date: 08/25/2026

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The purpose of this notice of funding opportunity (NOFO) is to establish a Center that educates and mentors researchers in formal product development for new substance use disorder (SUD) pharmacotherapeutics and to advance the best concepts through initial experiments via technical and financial support.

Amount: Unspecified

Due Date: 09/30/2026

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This program intends to fund high-impact research that bridges the gap between research, practice and policy by building real-world evidence on how interventions, clinical practices/guidelines, or policies can be deployed to targeted populations at the appropriate time. In order to meet this intent, the mechanism supports health services research approaches.

Amount: $4,000,000

Due Date: 09/24/2026 (LOI); 10/15/2026 (Full Proposal)

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