Research Insights

Large Grant Opportunities

Sign up for the large grant opportunities and limited submissions listserv. The Office of Research hosts a listserv that shares large funding opportunities and internal competition announcements weekly as well as a calendar of current limited submissions opportunities.

Leading Culture Change Through Professional Societies of Biology Wednesday, January 19, 2022 - The BIO-LEAPS program aims to advance diversity, equity and inclusion in the biological sciences broadly by leveraging the leadership, broad reach and unique ability of professional societies to create culture change in the life sciences.
Energy Frontier Research Centers Wednesday, January 19, 2022 - The DOE SC program in Basic Energy Sciences (BES) announces a re-competition of the Energy Frontier Research Center (EFRC) program and encourages both new and renewal applications.
DRL Internet Freedom Annual Program Statement Thursday, December 23, 2021 - The Bureau of Democracy, Human Rights and Labor requests Statements of Interest from organizations interested in developing programs that support Internet Freedom.
DOE: Biosystems Design to Enable Safe Production of Next-Generation Biofuels, Bioproducts and Biomaterials Thursday, December 23, 2021 - BER invests in crosscutting technologies and programs to enable multiscale, systems-level research to understand, predict, manipulate, and design biological processes that underpin innovations for bioenergy and bioproduct research.
USDE (IES): Research Networks Focused on Critical Problems of Education Policy and Practice; USDE (IES): Improving Pandemic Recovery Efforts in Education Agencies Thursday, December 23, 2021 - USDE (IES) announces two competitions—one to accelerate recovery and one to improve pandemic recovery in education agencies.
NSF: Future of Work at the Human-Technology Frontier Monday, December 13, 2021 - The objectives of the Future of Work at the Human-Technology Frontier program are to facilitate multidisciplinary or convergent research that prepares people for the future world of work.
NEH: Institutes for Advanced Topics in the Digital Humanities Wednesday, December 8, 2021 - The Institutes for Advanced Topics in the Digital Humanities program supports national or regional (multistate) training programs for scholars, humanities professionals, and graduate students to broaden and extend their knowledge of digital humanities.
NSF: Understanding the Rules of Life: Emergent Networks Wednesday, December 8, 2021 - Successful projects of the URoL:EN program are expected to use convergent approaches that explore emergent network properties of living systems across various levels of organizational scale and, ultimately, to contribute to understanding the rules of life through new theories and reliable predictions.
NSF Smart and Connected Communities (S&CC) Wednesday, December 8, 2021 - The S&CC program supports integrative research that addresses fundamental technological and social science dimensions of smart and connected communities and pilots solutions together with communities.
NEH: Institutes for Higher Education Faculty Tuesday, November 23, 2021 - NEH Institutes are professional development programs that convene higher education faculty from across the nation.
NEH: Landmarks of American History and Culture Tuesday, November 23, 2021 - Landmarks supports a series of one-week residential, virtual and combined format projects across the nation to enhance and strengthen how K-12 educators incorporate place-based teaching and learning in the humanities.
NIH: Basic Neurodevelopmental Biology of Circuits and Behavior (R01 Clinical Trial Not Allowed) Tuesday, November 23, 2021 - This FOA encourages research projects focused on the dynamic and mechanistic links between the maturation of brain circuits and behaviors across development in rodents and non-human primates.
NSF: Navigating the New Arctic Monday, November 8, 2021 - Navigating the New Arctic seeks innovations in fundamental convergence research across the social, natural, environmental, computing and information sciences, and engineering.
NIH: Identification and Characterization of Persistence Mechanisms of Select Protozoan Pathogens (R01) Monday, November 1, 2021 - The purpose of this FOA is to expand understanding of protozoan parasite persistence mechanisms.
NIH: Large Research Projects for Combating Antibiotic-Resistant Bacteria (CARB) (R01) Monday, November 1, 2021 - This FOA solicits applications for grant funding to conduct Large Health Services Research Projects (R01) focused on combating antibiotic-resistant bacteria.
Parkinson’s Foundation: Parkinson’s Foundation Research Centers Monday, November 1, 2021 - The Parkinson’s Foundation Research Centers is interested in proposals that tackle critical issues or problems that are impeding progress in the field of PD research.
NSF: Biodiversity on a Changing Planet (BoCP) Thursday, October 21, 2021 - The Biodiversity on a Changing Planet program is a cross directorate and international program led by NSF that invites submission of interdisciplinary proposals addressing grand challenges in biodiversity science within the context of unprecedented environmental change.
CDC: Vector-Borne Disease Regional Centers of Excellence Thursday, October 21, 2021 - The purpose of this NOFO is to support research to improve national capacity to address the growing problem of vector-borne diseases via continued support for regional Centers of Excellence for Vector-Borne Diseases.
NSF: Harnessing the Data Revolution (HDR): Transdisciplinary Research in Principles of Data Science Phase II (TRIPODS) Monday, October 18, 2021 - NSF's Harnessing the Data Revolution Big Idea is a national-scale activity to enable new modes of data-driven discovery that will allow fundamental questions to be asked and answered at the frontiers of science and engineering.
NSF: Computer and Information Science and Engineering (CISE) Community Research Infrastructure Program Monday, October 18, 2021 - The Computer and Information Science and Engineering Community Research Infrastructure program drives discovery and learning in the core CISE disciplines by funding the creation and enhancement of world-class research infrastructure.
NIH: Development of Microbiome-Related Approaches for Diagnosis/Mitigation/Treatment of Radiation Injuries (U01 Clinical Trial Not Allowed) Monday, October 11, 2021 - The purpose of this FOA is to support research that will advance the understanding of how the microbiome affects radiation injury.
DOC: US Marine Life Observations: Coordinated Marine Biodiversity Observation Network (MBON) and Animal Telemetry Network (ATN) Activities to Ensure Resilient, Productive Ecosystems and Human Communities in the Face of Change Monday, October 11, 2021 - This program supports proposals that: (1) build upon the foundation established by MBON, ATN and the US IOOS Regional Associations to work across sectors and disciplines towards an integrated, sustained marine life observing capability for the U.S. ocean, coasts and Great Lakes, from estuaries to the deep ocean.
NIH: Systems Biology for Infectious Diseases (U19 Clinical Trial Not Allowed) Monday, October 11, 2021 - The purpose of the FOA is to support research that employs systems biology approaches to human pathogens.
NIH: SPARC Human Open Research Neural Engineering Technologies (HORNET) Initiative (U41) Monday, October 11, 2021 - This U41 opportunity will fund centers to create interoperable open-source modules that can be combined into custom profiles for new exploratory and clinical neuromodulation studies in the peripheral nervous system, and for potential applicability in the central nervous system.
NIH: Pediatric Obesity Discovery Science Research to Improve Understanding of Risk and Causal Mechanisms for Obesity in Early Life (R01) Monday, October 11, 2021 - The purpose of this FOA is to support innovative, discovery research studies to better characterize early-life risk factors and elucidate underlying causal mechanisms through which these risk factors contribute to the development of obesity during infancy and early childhood.
NSF: Integrative Research in Biology (IntBIO) Saturday, September 25, 2021 - This solicitation invites submission of collaborative proposals that tackle bold questions in biology and require an integrated approach to make substantive progress.
NSF: Cyberinfrastructure for Sustained Scientific Innovation (CSSI) Saturday, September 25, 2021 - This solicitation expands the Cyberinfrastructure for Sustained Scientific Innovation program by adding a new project class: Transition to Sustainability.
NSF: Biology Integration Institutes (BII) Tuesday, September 21, 2021 - The NSF Directorate for Biological Sciences program for Biology Integration Institutes (BII) supports diverse and collaborative teams of researchers investigating questions that span multiple disciplines within and beyond biology.
NSF: EHR Core Research – Resource Coordination Hub (ECR Hub) Monday, September 13, 2021 - NSF seeks proposals to create an EHR Core Research (ECR) Resource Coordination Hub (ECR Hub) that will be an intellectual partner to the ECR:Core and the ECR:BCSER grantee communities and the NSF to enhance the overall influence and reach of ECR STEM education research investments.
DOE: Natural Gas Demand Response Pilot Program Monday, September 13, 2021 - FOA soliciting cooperative agreements for the development of multiple regional natural gas demand response pilot programs in collaboration with utilities, local distribution companies and public utility commissions.
NEH: Digital Humanities Advancement Grants Monday, September 13, 2021 - computationally challenging digital projects, leading to work that can scale to enhance scholarly research, teaching and public programming in the humanities.
NSF: Facility and Instrumentation Request Process (FIRP) Monday, September 13, 2021 - The Facility and Instrumentation Request Process (FIRP) solicitation describes the mechanism by which the research community can propose projects that require access to instrumentation and facilities sponsored by the FARE Program.
NIH: National Cancer Institute Youth Enjoy Science Research Education Program (R25) Friday, September 3, 2021 - This funding opportunity seeks to facilitate the education of students from diverse backgrounds underrepresented in biomedical research who will become knowledgeable about cancer, and available to focus on cancer later in their careers.
NSF: Reproducible Cells and Organoids via Directed-Differentiation Encoding (RECODE) Tuesday, August 31, 2021 - Several NSF divisions seek proposals that elucidate mechanisms of, and develop strategies to, direct the differentiation of undifferentiated cells into mature, functional cells or organoids.
NSF: NSF-Simons Collaboration on a National Institute for Theory and Mathematics in Biology Monday, August 23, 2021 - The purpose of the NSF-Simons Collaboration on a National Institute for Theory and Mathematics in Biology is to support a research institute to enable innovative research at the intersection of mathematical and biological sciences to facilitate new developments of biology-inspired mathematical theories, methodologies and innovative modeling approaches to advance the understanding of challenging biological problems.
NIH: Effectiveness of Implementing Sustainable Evidence-Based Mental Health Practices in Low-Resource Settings to Achieve Mental Health Equity for Traditionally Underserved Populations (R01 Clinical Trial Optional) Tuesday, August 17, 2021 - This FOA encourages studies that develop and test the effectiveness of strategies for implementation and sustainable delivery of evidence-based mental health treatments and services to improve mental health outcomes for underserved populations in low-resourced settings in the U.S. 
HRSA: Optimizing Momentum Toward Sustainable Epidemic Control Friday, July 9, 2021 - As PEPFAR countries get closer to achieving Epidemic Control, there will be a need for unique solutions in countries seeking to attain and sustain long-term epidemic control, from determining the most effective delivery systems for a particular population, region, or country, to transforming the latest scientific breakthroughs into sustainable service delivery models, improving health workforce capacity and beyond.
NSF: CISE Community Research Infrastructure (CCRI) Tuesday, July 6, 2021 - NSF's CISE Community Research Infrastructure program drives discovery and learning in the core CISE disciplines of the three participating divisions by funding the creation and enhancement of world-class research infrastructure.
NSF: Mathematical Sciences Research Institutes Tuesday, July 6, 2021 - The goals of the Mathematical Sciences Research Institutes program include advancing research in the mathematical sciences, increasing the impact of the mathematical sciences in other disciplines, and expanding the talent base engaged in mathematical research in the United States.
NIH: Grand Opportunity in Medications Development for Substance-Use Disorders (U01 – Clinical Trial Optional) Friday, August 14, 2020 - The purpose of this FOA is to accelerate the development of medication for the treatment of Substance Use Disorders (SUDs) by encouraging research applications to support a diverse array of preclinical and/or clinical research projects.
FY2021 Vannevar Bush Faculty Fellowship Friday, July 10, 2020 - This FOA seeks distinguished researchers for the purpose of conducting innovative basic research in areas of interest to the DoD and fostering long-term relationships between the VBFF Fellows and the DoD.
Tobacco Use and HIV in Low and Middle-Income Countries (U01 Clinical Trial Optional) Friday, July 10, 2020 - This FOA supports the development and evaluation of tobacco cessation interventions tailored to HIV-positive populations, including those with comorbidities such as tuberculosis (TB), in low-resource settings in low- and middle-income countries.
Limited Submission: Continuation of the Human Pancreas Analysis Program (HPAP) for Type 1 Diabetes (HPAP-T1D) (U01 Clinical Trial Not Allowed) Friday, July 10, 2020 - This FOA will support one team of investigators with combined expertise in human pancreas physiology and pathophysiology; collection, processing and multimodal analysis of human pancreatic tissues; and biological database building, curation and management.
Network of the National Library of Medicine Evaluation Center (U24) (Clinical Trial Not Allowed) Monday, July 6, 2020 - The NNLM Evaluation Center (NEC) will coordinate the assessment of the impact, efficacy and value of NNLM activities, services, and resources. A special focus will be placed on assessing community engagement and measuring its impact on persons who experience health disparities, and populations underrepresented in biomedical research.
Technical Assistance and Dissemination to Improve Services and Results for Children with Disabilities and Demonstration and Training Programs Monday, July 6, 2020 - The purpose of the program is to promote academic achievement and to improve results for children with disabilities by providing TA, supporting model demonstration projects, disseminating useful information, and implementing activities that are supported by scientifically based research.
Pediatric Biospecimen Procurement Center (BPC) Supporting the Developmental Gene Expression (dGTEx) Project (U24 Clinical Trial Not Allowed) Monday, July 6, 2020 - The purpose of this funding opportunity is for support of a Biospecimen Procurement Center (BPC) to enroll suitable pediatric donors and provide high quality tissue samples for analyses to the Laboratory, Data Analysis, and Coordinating Center.
Laboratory, Data Analysis, and Coordinating Center (LDACC) for the Developmental Genotype-Tissue Expression Project(U24) (Clinical Trial Not Allowed) Monday, July 6, 2020 - The LDACC will perform 2 major functions: a molecular laboratory to process tissue samples for sequencing and biobanking, and a data analysis and coordinating center to ensure coordination, monitor study progress and laboratory performance, perform basic analysis of data for gene expression analyses, and harmonize and submit datasets to be deposited in repositories such as the AnVIL (Analysis, Visualization, and Informatics Lab-space).
NIH: Hybrid Effectiveness-Implementation Trials for Heart, Lung, Blood, and Sleep Diseases in the Inpatient Setting (U01 – Clinical Trials Required) Friday, June 19, 2020 - This FOA supports hybrid effectiveness-implementation trials for heart, lung, blood, and sleep (HLBS) diseases in the inpatient setting and applications that propose a multidisciplinary research team that includes expertise in inpatient clinical research, implementation research, and biostatistics.
NIH: NIDA Avant-Garde Award Program for HIV/AIDS and Substance Use Disorder Research (DP1, Clinical Trial Optional) Friday, June 5, 2020 - Supports exceptionally creative scientists, who propose high-impact research that will open new areas of HIV/AIDS research in the context of substance use disorders and/or lead to new avenues for prevention and treatment of HIV/AIDS in people who use drugs.
NIH: Regenerative Medicine Innovation Project (RMIP) Investigator-Initiated Clinical Trials (UG3/UH3 Clinical Trial Required) Friday, June 5, 2020 - Seeks meritorious clinical trials proposing to explore and enable the development of safe and effective regenerative medicine interventions using adult stem cells.