Research Insights
Large Grant Opportunities
The Office of Research hosts a listserv that shares large funding opportunities and internal limited submissions competition announcements weekly, in addition to maintaining a calendar of current limited submissions opportunities. Sign up for the Large Grant Opportunities and Limited Submissions listserv to receive weekly updates.
NIH: Leveraging Network Infrastructure to Conduct Innovative Research for Women, Children, Pregnant and Lactating Women, and Persons with Disabilities (UG3/UH3 – Clinical Trial Optional) Friday, February 27, 2026 - This program leverages the NICHD clinical research network infrastructure relevant to infants, children, women, and persons with disabilities to conduct innovative, multisite, investigator-initiated clinical trials and observational studies. Amount: $6,250,000 Due Date: 07/15/2026 More information
NIH: Advanced Laboratories for Accelerating the Reach and Impact of Treatments for Youth and Adults with Mental Illness (ALACRITY) Research Centers (P50 Clinical Trial Optional) Friday, February 27, 2026 - This NOFO invites applications for centers to support transdisciplinary teams to engage in high-impact studies that will significantly advance clinical practice and generate knowledge that will fuel transformation of mental health care in the United States. Amount: $11,325,000 Due Date: 04/18/2026 (LOI); 05/18/2026 (Full Proposal) More information
NSF: Mid-scale Research Infrastructure-1 (Mid-scale RI-1) Friday, February 27, 2026 - This program supports the design and implementation of research infrastructure — including equipment, cyberinfrastructure, large-scale datasets and personnel — whose total project costs are under $20 million. Amount: $4,000,000 – $19,999,999 Due Date: 09/01/2026 (Pre-Proposals); 02/08/2027 (Full Proposals) More information
NIH: Impact of Initial Influenza Exposure on Immunity in Infants (U01 Clinical Trial Not Allowed) Monday, February 23, 2026 - This program aims to support the establishment or continuation of longitudinal infant cohorts to determine and compare how initial and repeated natural influenza infections and/or influenza vaccinations shape infant and childhood immunity to future influenza exposures. The goal is to understand how these exposures influence immune responses to subsequent influenza infections and/or vaccines and provide […]
NIH: National Centers for Cryo-electron Tomography (cryoET) (R24 -Clinical Trial Not Allowed) Thursday, February 12, 2026 - This Notice of Funding Opportunity (NOFO) is for support of National Centers for Cryoelectron Tomography (CryoET) to provide nationwide access to advanced cryoET instrumentation and technical support, and to assist investigators in acquiring the skills needed to perform cryoET studies. Amount: Unspecified Due Date: 01/26/2027 More Information:
Prostate Cancer Foundation: 2026 PCF Challenge Awards Thursday, February 5, 2026 - The Prostate Cancer Foundation (PCF) is pleased to announce a Request for Applications for PCF Challenge Awards for Team Science investigations of prostate cancer with lethal potential. These awards will be funded depending on the level of innovation in applications received. PCF seeks high-risk, currently unfunded projects from academic and community research institutions around the […]
Children’s Cancer Research Fund 2026 Accelerating Hope: Clinical Trials for Hard-to-Treat Cancers Award Thursday, February 5, 2026 - This grant mechanism provides support for clinical trials focused on hard-to-treat childhood cancers. Amount: $1,000,000 Due Date: 08/07/2026 (LOI); 11/16/2026 (Full Proposal) More Information:
IMLS: Museums for America (2026) Monday, February 2, 2026 - This program invests in museums of all sizes and disciplines in project-based efforts to serve the public through educational programs and exhibits, community partnerships, and collections stewardship activities. Amount: $5,000 – $300,000 Due Date: 03/13/2026 More information
IMLS: 21st Century Museum Professionals Program (2026) Tuesday, January 27, 2026 - The 21st Century Museum Professional (21MP) grant program supports projects that build career pathways, strengthen professional networks, and identify and share effective workforce education and training practices in the museum field. Amount: $100,000 – $500,000 Due Date: 03/13/2026 More Information
Prostate Cancer Foundation: 2026 PCF TACTICAL Awards Tuesday, January 27, 2026 - PCF seeks applications for currently unfunded, large-scale multi-disciplinary team science research projects that will directly contribute to reducing death and suffering from prostate cancer, and will deliver transformative and tangible outcomes in the 3-5- year funding period. This includes basic, translational, clinical, and community-based research projects focused on strategies to prevent prostate cancer metastasis, morbidity, […]
NIH: Informatics, Coordination and Service Center for the Mutant Mouse Resource and Research Centers (U42 Clinical Trial Not Allowed) Tuesday, January 6, 2026 - The purpose of this opportunity is to support the Informatics, Coordination and Service Center (ICSC) unit of the Mutant Mouse Resource and Research Centers (MMRRC) consortium. The ICSC supports the MMRRC in its mission to provide mutant mice, sperm, embryos, and embryonic stem (ES) cell lines to qualified biomedical researchers at research centers, academic institutions, […]
NIH: Maximizing Investigators’ Research Award (MIRA) Tuesday, January 6, 2026 - MIRA provides support for research in an investigator’s laboratory that falls within the mission of NIGMS. The goal of MIRA is to increase the efficiency of NIGMS funding by providing investigators with greater stability and flexibility, thereby enhancing scientific productivity and the chances for important breakthroughs. Amount: $5,662,500 Due Date: 05/27/2026 More information
NSF: Collaboratory to Advance Mathematics Education and Learning for K-12 Wednesday, December 17, 2025 - This initiative aims to advance mathematics learning and education through purposeful collaboration that draws on the interdisciplinary Science of Learning (including neuroscience; cognitive, developmental, and social sciences; computer science; machine learning; engineering; and education research), deep experiences in education practice and teaching, and innovations in the use of data science, AI and technology. Amount: $1,500,000 […]
NSF: Trailblazer Engineering Impact Award (TRAILBLAZER) Tuesday, December 9, 2025 - This program supports individual investigators who propose novel research projects with the potential to innovatively and creatively address new areas of fundamental or applied research, catalyze development of new industries or capabilities that increase the leadership position for the country, and/or make significant progress towards addressing a national need or grand challenge. Amount: Up to […]
NIH: Animal and Biological Material Resource Centers (P40 Clinical Trial Not Allowed) Tuesday, December 9, 2025 - Centers supported by this program provide support for special colonies of laboratory animals and associated services, as well as other resources such as informatics tools, reagents, cultures (cells, tissues, and organs) and genetic stocks that serve the biomedical research community in a variety of research areas on a local, regional, and national basis. Amount: Unspecified […]
NSF: Mathematical Foundations of Artificial Intelligence Monday, November 24, 2025 - This program supports research collaborations between mathematicians, statisticians, computer scientists, engineers and social behavior scientists to establish innovative and principled design and analysis approaches for AI technology. Amount: $500,000 – $1,500,000 Due Date: 10/09/2026 More Information
Hereditary Disease Foundation: Transformative Research Award Program Monday, November 24, 2025 - This program will make funds available to advance transformational collaborative projects that will provide new insights into disease mechanisms or create or implement tools and technologies not previously applied to Huntington’s disease (HD) research for the advancement of therapeutics. Amount: $600,000 – $1,000,000 Due Date: 01/15/2026 (LOI); 04/30/2026 (Invited Full Proposals) More Information
NSF: Expeditions in Computing (Expeditions) Friday, November 14, 2025 - This program supports long-term, multi-institutional research with the potential to transform computer and information science and engineering. Amount: Up to $15,000,000 Due Date: 06/22/2026 (Pre-Proposals) More Information
NIH: Advanced Laboratories for Accelerating the Reach and Impact of Treatments for Youth and Adults with Mental Illness (ALACRITY) Research Centers (P50 Clinical Trial Optional) Friday, October 24, 2025 - This program invites applications for centers to support transdisciplinary teams of clinical and mental health services researchers, behavioral scientists, social scientists, health information and communications technologists, health systems engineers, decision scientists, and mental health stakeholders to engage in high-impact studies that will significantly advance clinical practice and generate knowledge that will fuel transformation of mental […]
Lupus Research Alliance: Global Team Science Award Wednesday, July 9, 2025 - This program supports interdisciplinary, collaborative, and highly synergistic projects that focus on the molecular understanding of human lupus and the heterogeneity of the disease. Successful teams will push the boundaries of innovation and bridge research and clinical efforts in lupus by using cutting-edge technologies to address critical questions that could bring about breakthroughs in lupus […]
NSF: Expeditions in Computing (Expeditions) Thursday, May 8, 2025 - NSF: Expeditions in Computing (Expeditions) This program provides the Computer and Information Science and Engineering (CISE) research and education community with the opportunity to pursue ambitious, fundamental research agendas that promise to define the future of computing and information. Amount: $15,000,000 Due Date: 06/22/2026 (Pre-Proposals) More Information
Georgia Network for Electric Mobility Seed Grants Tuesday, November 26, 2024 - This program supports interdisciplinary research in e-mobility related topics along the electric vehicle/mobility value chain such as battery manufacturing and rare earth materials mining, supply chain and logistics, vehicle manufacturing, charging infrastructure and utilities, sales and consumer knowledge, and battery and EV components/materials recycling. Amount: $40,000 up to $60,000 per award Proposal due date: December 18, […]
NIH: Building Interdisciplinary Research Careers in Women’s Health (BIRCWH) (K12 Clinical Trial Optional) Monday, March 18, 2024 - This program supports mentored research career development of junior faculty members who have recently completed clinical training or postdoctoral fellowships, and who will be engaged in interdisciplinary basic, translational, data science, behavioral, clinical, and/or health services research relevant to the health of women and, where appropriate, the use of both sexes to better understand the […]
NIH: Individually Measured Phenotypes to Advance Computational Translation in Mental Health Wednesday, May 10, 2023 - Supports the work of the research projects funded under the Individually Measured Phenotypes to Advance Computational Translation in Mental Health (IMPACT-MH) initiative described in the companion announcement RFA-MH-23-105. Amount: $18,875,000 Due Date: 6/14/23 More Information
NEH: Digital Projects for the Public Wednesday, March 22, 2023 - This program supports projects that interpret and analyze humanities content in primarily digital platforms and formats, such as websites, mobile applications and tours, interactive touch screens and kiosks, games, and virtual environments. Amount: $400,000 Due Date: 6/14/23 More Information
NIH: Development of Novel Nonsteroidal Contraceptive Methods Tuesday, October 18, 2022 - Supports multidisciplinary research approaches for the development of novel nonsteroidal contraceptive products for men and women that act prior to fertilization. Amount: $3,020,000 Due Date: 3/29/23 More information
NIH: BRAIN Initiative: Exploratory Team-Research BRAIN Circuit Programs Wednesday, March 16, 2022 - Supports interdisciplinary teams to elucidate the contributions of dynamic circuit activity to a specific behavioral or neural system.
NSF: Biodiversity on a Changing Planet (BoCP) Thursday, October 21, 2021 - The Biodiversity on a Changing Planet program is a cross directorate and international program led by NSF that invites submission of interdisciplinary proposals addressing grand challenges in biodiversity science within the context of unprecedented environmental change.
CDC: Vector-Borne Disease Regional Centers of Excellence Thursday, October 21, 2021 - The purpose of this NOFO is to support research to improve national capacity to address the growing problem of vector-borne diseases via continued support for regional Centers of Excellence for Vector-Borne Diseases.
NSF: Harnessing the Data Revolution (HDR): Transdisciplinary Research in Principles of Data Science Phase II (TRIPODS) Monday, October 18, 2021 - NSF's Harnessing the Data Revolution Big Idea is a national-scale activity to enable new modes of data-driven discovery that will allow fundamental questions to be asked and answered at the frontiers of science and engineering.
NSF: Computer and Information Science and Engineering (CISE) Community Research Infrastructure Program Monday, October 18, 2021 - The Computer and Information Science and Engineering Community Research Infrastructure program drives discovery and learning in the core CISE disciplines by funding the creation and enhancement of world-class research infrastructure.
NIH: Development of Microbiome-Related Approaches for Diagnosis/Mitigation/Treatment of Radiation Injuries (U01 Clinical Trial Not Allowed) Monday, October 11, 2021 - The purpose of this FOA is to support research that will advance the understanding of how the microbiome affects radiation injury.
DOC: US Marine Life Observations: Coordinated Marine Biodiversity Observation Network (MBON) and Animal Telemetry Network (ATN) Activities to Ensure Resilient, Productive Ecosystems and Human Communities in the Face of Change Monday, October 11, 2021 - This program supports proposals that: (1) build upon the foundation established by MBON, ATN and the US IOOS Regional Associations to work across sectors and disciplines towards an integrated, sustained marine life observing capability for the U.S. ocean, coasts and Great Lakes, from estuaries to the deep ocean.
NIH: Systems Biology for Infectious Diseases (U19 Clinical Trial Not Allowed) Monday, October 11, 2021 - The purpose of the FOA is to support research that employs systems biology approaches to human pathogens.
NIH: SPARC Human Open Research Neural Engineering Technologies (HORNET) Initiative (U41) Monday, October 11, 2021 - This U41 opportunity will fund centers to create interoperable open-source modules that can be combined into custom profiles for new exploratory and clinical neuromodulation studies in the peripheral nervous system, and for potential applicability in the central nervous system.
NIH: Pediatric Obesity Discovery Science Research to Improve Understanding of Risk and Causal Mechanisms for Obesity in Early Life (R01) Monday, October 11, 2021 - The purpose of this FOA is to support innovative, discovery research studies to better characterize early-life risk factors and elucidate underlying causal mechanisms through which these risk factors contribute to the development of obesity during infancy and early childhood.
NSF: Integrative Research in Biology (IntBIO) Saturday, September 25, 2021 - This solicitation invites submission of collaborative proposals that tackle bold questions in biology and require an integrated approach to make substantive progress.
NSF: Cyberinfrastructure for Sustained Scientific Innovation (CSSI) Saturday, September 25, 2021 - This solicitation expands the Cyberinfrastructure for Sustained Scientific Innovation program by adding a new project class: Transition to Sustainability.
NSF: Biology Integration Institutes (BII) Tuesday, September 21, 2021 - The NSF Directorate for Biological Sciences program for Biology Integration Institutes (BII) supports diverse and collaborative teams of researchers investigating questions that span multiple disciplines within and beyond biology.
NSF: EHR Core Research – Resource Coordination Hub (ECR Hub) Monday, September 13, 2021 - NSF seeks proposals to create an EHR Core Research (ECR) Resource Coordination Hub (ECR Hub) that will be an intellectual partner to the ECR:Core and the ECR:BCSER grantee communities and the NSF to enhance the overall influence and reach of ECR STEM education research investments.
DOE: Natural Gas Demand Response Pilot Program Monday, September 13, 2021 - FOA soliciting cooperative agreements for the development of multiple regional natural gas demand response pilot programs in collaboration with utilities, local distribution companies and public utility commissions.
NEH: Digital Humanities Advancement Grants Monday, September 13, 2021 - computationally challenging digital projects, leading to work that can scale to enhance scholarly research, teaching and public programming in the humanities.
NSF: Facility and Instrumentation Request Process (FIRP) Monday, September 13, 2021 - The Facility and Instrumentation Request Process (FIRP) solicitation describes the mechanism by which the research community can propose projects that require access to instrumentation and facilities sponsored by the FARE Program.
NIH: National Cancer Institute Youth Enjoy Science Research Education Program (R25) Friday, September 3, 2021 - This funding opportunity seeks to facilitate the education of students from diverse backgrounds underrepresented in biomedical research who will become knowledgeable about cancer, and available to focus on cancer later in their careers.
NSF: Mathematical Sciences Research Institutes Tuesday, July 6, 2021 - The goals of the Mathematical Sciences Research Institutes program include advancing research in the mathematical sciences, increasing the impact of the mathematical sciences in other disciplines, and expanding the talent base engaged in mathematical research in the United States.
FY2021 Vannevar Bush Faculty Fellowship Friday, July 10, 2020 - This FOA seeks distinguished researchers for the purpose of conducting innovative basic research in areas of interest to the DoD and fostering long-term relationships between the VBFF Fellows and the DoD.
Tobacco Use and HIV in Low and Middle-Income Countries (U01 Clinical Trial Optional) Friday, July 10, 2020 - This FOA supports the development and evaluation of tobacco cessation interventions tailored to HIV-positive populations, including those with comorbidities such as tuberculosis (TB), in low-resource settings in low- and middle-income countries.
Limited Submission: Continuation of the Human Pancreas Analysis Program (HPAP) for Type 1 Diabetes (HPAP-T1D) (U01 Clinical Trial Not Allowed) Friday, July 10, 2020 - This FOA will support one team of investigators with combined expertise in human pancreas physiology and pathophysiology; collection, processing and multimodal analysis of human pancreatic tissues; and biological database building, curation and management.
Network of the National Library of Medicine Evaluation Center (U24) (Clinical Trial Not Allowed) Monday, July 6, 2020 - The NNLM Evaluation Center (NEC) will coordinate the assessment of the impact, efficacy and value of NNLM activities, services, and resources. A special focus will be placed on assessing community engagement and measuring its impact on persons who experience health disparities, and populations underrepresented in biomedical research.
Technical Assistance and Dissemination to Improve Services and Results for Children with Disabilities and Demonstration and Training Programs Monday, July 6, 2020 - The purpose of the program is to promote academic achievement and to improve results for children with disabilities by providing TA, supporting model demonstration projects, disseminating useful information, and implementing activities that are supported by scientifically based research.
Pediatric Biospecimen Procurement Center (BPC) Supporting the Developmental Gene Expression (dGTEx) Project (U24 Clinical Trial Not Allowed) Monday, July 6, 2020 - The purpose of this funding opportunity is for support of a Biospecimen Procurement Center (BPC) to enroll suitable pediatric donors and provide high quality tissue samples for analyses to the Laboratory, Data Analysis, and Coordinating Center.
Laboratory, Data Analysis, and Coordinating Center (LDACC) for the Developmental Genotype-Tissue Expression Project(U24) (Clinical Trial Not Allowed) Monday, July 6, 2020 - The LDACC will perform 2 major functions: a molecular laboratory to process tissue samples for sequencing and biobanking, and a data analysis and coordinating center to ensure coordination, monitor study progress and laboratory performance, perform basic analysis of data for gene expression analyses, and harmonize and submit datasets to be deposited in repositories such as the AnVIL (Analysis, Visualization, and Informatics Lab-space).
NIH: Hybrid Effectiveness-Implementation Trials for Heart, Lung, Blood, and Sleep Diseases in the Inpatient Setting (U01 – Clinical Trials Required) Friday, June 19, 2020 - This FOA supports hybrid effectiveness-implementation trials for heart, lung, blood, and sleep (HLBS) diseases in the inpatient setting and applications that propose a multidisciplinary research team that includes expertise in inpatient clinical research, implementation research, and biostatistics.
NIH: NIDA Avant-Garde Award Program for HIV/AIDS and Substance Use Disorder Research (DP1, Clinical Trial Optional) Friday, June 5, 2020 - Supports exceptionally creative scientists, who propose high-impact research that will open new areas of HIV/AIDS research in the context of substance use disorders and/or lead to new avenues for prevention and treatment of HIV/AIDS in people who use drugs.
NIH: Regenerative Medicine Innovation Project (RMIP) Investigator-Initiated Clinical Trials (UG3/UH3 Clinical Trial Required) Friday, June 5, 2020 - Seeks meritorious clinical trials proposing to explore and enable the development of safe and effective regenerative medicine interventions using adult stem cells.