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This program supports multidisciplinary consortia of structural biologists, microbiologists, and associated experts to solve complex biological structures related to the prevention, treatment, and cure of HIV and other infectious diseases. Centers are expected to facilitate new collaborations, leverage shared resources, offer services and resources to the research community, and train the next generation of scientists engaged in structural biology of infectious diseases.

Amount: $5,320,000

Due Date: 05/28/2027

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The purpose of this program is the rapid and efficient translation of innovative laboratory research findings into therapeutics for use by clinicians to treat visual system diseases or disorders. The TRP will support the product development of biological, pharmaceutical, medical device, and/or combination therapies for any disease or disorder of the visual system.

Amount: $6,840,000

Due Date: 02/16/2027

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This program supports pioneering immunotherapy clinical trials designed and led by academic researchers. These investigator-initiated studies are vital to improving patient outcomes, addressing areas of high unmet need, and generating critical mechanistic insights that can guide the future of cancer treatment.

Amount: $1,000,000

Due Date: 12/01/2026 (LOI); 04/01/2027 (Invited Full Proposal)

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NCI is soliciting applications for the establishment of the Management and Data Coordination Unit (MDCU) for the Pancreatic Cancer Detection Consortium (PCDC). The PCDC will continue to conduct research on early detection of pancreatic ductal adenocarcinoma (PDAC) and characterization of its precursor lesions to identify those patients who are at high risk of progression to cancer. The PCDC-MDCU will provide support towards collaborative efforts such as study design, protocol development, statistical analysis, coordination and data management.

Amount: $3,800,000

Due Date: 01/25/2027

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NCI solicits applications for Research Units (RUs) to conduct research on early detection of pancreatic ductal adenocarcinoma (PDAC) and characterization of its precursor lesions to identify patients who are at high risk of progression to cancer. The Consortium will support research for the development and testing of new molecular and imaging biomarkers for detecting PDAC early and for identifying patients at high risk of PDAC who could be candidates for early intervention. 

Amount: $4,560,000

Due Date: 02/05/2027

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This program solicits proposals from U.S. institutions of higher education (IHEs) for IHE-led, early-stage, sustained, multidisciplinary space-technology research focused in strategic areas for transformative impact to future NASA and other civil-space applications.

Amount: $13,000,000

Due Date: 11/03/2026 (Pre-Proposal)

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This program aims to stimulate progress on fundamental scientific questions of major importance in mathematics, theoretical physics and theoretical computer science. Applicants should address a mathematical or theoretical topic of fundamental scientific importance, where a significant, new development creates a novel area for exploration or provides a new direction for progress in an established field.

Amount: $8,000,000

Due Date: 10/29/2026 (LOI); 02/25/2027 (Invited Full Proposals)

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This program supports large, multidisciplinary teams pursuing ambitious, long-term foundational research to drive transformative advances in computing, information science and engineering.

Amount: Up to $15,000,000

Due Date: 12/02/2026 (Pre-Proposal); 07/27/2027 (Full Proposal)

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This program is intended to facilitate research that will contribute to the development of new therapies or therapeutic strategies to treat cystic fibrosis with an emphasis on advancing CFTR gene repair and replacement approaches.

Amount: $1,000,000

Due Date: 12/15/2026

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The purpose of NEI’s Translational Research program (TRP) is the rapid and efficient translation of innovative laboratory research findings into therapeutics for use by clinicians to treat visual system diseases or disorders. The TRP will support the product development of biological, pharmaceutical, medical device, and/or combination therapies for any disease or disorder of the visual system.

Amount: $6,080,000

Due Date: 02/16/2027

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