This program’s purpose is to leverage NICHD clinical research network infrastructure relevant to infants, children, women, pregnant and lactating individuals, and persons with disabilities to conduct innovative, multisite, investigator-initiated clinical trials and observational studies.
Amount: $6,250,000
DueDate: 07/15/2025
This opportunity seeks to leverage cutting-edge advances in multimodal artificial intelligence (AI) to accelerate HIV diagnosis, prevention, and treatment.
Amount: $5,662,500
DueDate: 02/27/2025 (LOI); 03/27/2025 (Full Proposal)
The central goal of this NOFO is to establish robust proof of concept in mouse models or cell-based models of AD/ADRD that will enable rational drug repositioning and the development of precision combination therapies for the treatment and prevention of AD/ADRD.
Amount: $7,550,000
Due Date: 06/09/2025; 10/06/2025
This program supports research to advance the development of safe and effective medications for the treatment of Substance Use Disorders (SUD). The goal is to fund studies that will have high impact and quickly yield the necessary results to advance medications closer to FDA approval.
Amount: $22,650,000
Due Date: 03/10/2025 (LOI); 04/10/2025 (Full Proposal)
This program supports work that enables scientists and scientific discovery by improving the security, robustness, and trustworthiness of cyberinfrastructure.
Amount: Varies by award type
Due Date: 04/02/2025
The Office of Research announces the FY 2026 cycle for the Faculty Seed Grants in the Sciences and Engineering.
The goal of the Faculty Seed Grants in the Sciences and Engineering is to enable faculty to launch new, promising lines of research for which resources are currently not available. These seed grants are intended to fund pilot research generating preliminary data that will be leveraged to compete for externally funded grant/contract opportunities and contribute to a sustainable program of research and scholarship. Basic and applied research in the social, life, physical sciences, and engineering are eligible for funding through this program. (Note: The Office of Research funds research grants in Humanities and Arts through a separate program managed by the Willson Center).
All faculty (tenure-track and non-tenure track) with research EFT (equivalent full-time) are eligible with the following exceptions: 1) Applicants may not have access to more than $25,000 in institutional or discretionary research funding (e.g., start-up, salary returns, or IDC returns) during the award year (i.e., FY26); 2) Tenured applicants may not have received more than $50,000 in institutional research support in the past three years (FY23 or later). Examples of institutional research support include bridge funding, a Presidential Seed Grant or other internal seed grant; and 3) An applicant may not have received a Faculty Seed Grant from this program within the last three years (an FY23 grant or later).
See the guidelines on the Office of Research Internal Grants webpage. Answers to frequently asked questions, award conditions, and other information are on the Faculty Seed Grants FAQs page.
The deadline for proposal submission is 11:59 pm on Saturday, March 1, 2025.
Grants for successful applications will be awarded with a start date of July 1, 2025 (FY26).
This program encourages multi-PI, multi-institutional research to submit proposals on transformative approaches and solutions in materials, devices, theory, and systems to realize the innovative REsearch in FLoquet Engineered QuanTum Systems (REFLEQTS).
Amount: $3,000,000
Due Date: 01/24/2025 (Expression of Interest); 03/14/2025 (Full Proposal)
This program invites applications proposing pre-clinical and early stage clinical (Phase I) development of novel small-molecule and biologic drug candidates that aim to prevent Alzheimer’s disease, slow its progression, or treat its cognitive and behavioral symptoms.
Amount: $11,325,000
Due Date: 05/05/2025 (LOI); 06/05/2025 (Full Proposal)
This partnership between the NSF and NEH supports projects to develop and advance knowledge concerning dynamic language infrastructure in the context of endangered human languages — languages that are both understudied and at risk of falling out of use.
Amount: $450,000
Due Date: 09/15/2025
This program supports exceptionally creative scientists, who propose high-impact studies that open new areas of HIV research in the context of substance use and Substance Use Disorders (SUD) and/or lead to new avenues for prevention and treatment of HIV in people with SUD.
Amount: $5,285,000
Due Date: 07/15/2025 (LOI); 08/15/2025 (Full Proposal)
