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This NOFO solicits applications for the continued development and sustainment of high value informatics research resources to improve the acquisition, management, analysis, and dissemination of data and knowledge across the cancer research continuum including cancer biology, cancer treatment and diagnosis, early cancer detection, risk assessment and prevention, cancer control and epidemiology.

Amount: $4,560,000

Due Date: 10/19/2026

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This NOFO solicits applications for the continued development and sustainment of high value informatics research resources to improve the acquisition, management, analysis, and dissemination of data and knowledge across the cancer research continuum including cancer biology, cancer treatment and diagnosis, early cancer detection, risk assessment and prevention, cancer control and epidemiology.

Amount: $4,560,000

Due Date: 10/19/2026

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This program solicits applications for research on developing a comprehensive and cohesive understanding of cancer metastasis. Each MetNet Center should propose an overarching scientific theme that will be pursued through two or three scientific inter- and multidisciplinary basic research projects. Studies on all types of cancer are welcome, including rare and pediatric metastatic cancers. Proposed research is expected to advance our understanding towards a more comprehensive appreciation of metastasis as a whole body, systems-level problem.

Amount: $9,880,000

Due Date: 08/25/2026

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This NOFO invites applications for KPMP Tissue Interrogation Sites to use highly integrated multi-modal analytic pipelines to interrogate human kidney biopsy tissue to discover and define new disease pathways and subgroups that enable precision clinical trials.

Amount: $11,400,000

Due Date: 07/10/2026

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The purpose of this notice of funding opportunity (NOFO) is to establish a Center that educates and mentors researchers in formal product development for new substance use disorder (SUD) pharmacotherapeutics and to advance the best concepts through initial experiments via technical and financial support.

Amount: Unspecified

Due Date: 09/30/2026

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This program intends to fund high-impact research that bridges the gap between research, practice and policy by building real-world evidence on how interventions, clinical practices/guidelines, or policies can be deployed to targeted populations at the appropriate time. In order to meet this intent, the mechanism supports health services research approaches.

Amount: $4,000,000

Due Date: 09/24/2026 (LOI); 10/15/2026 (Full Proposal)

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This NOFO invites applications for the enhancement and dissemination of emerging, user-friendly informatics technologies that support a wide range of cancer research, including discovery biology, population studies, as well as clinical and translational research. The emphasis is on uniqueness and potential impact on cancer research.

Amount: $4,560,000

Due Date: 10/19/2026

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This program supports clinical trials with the potential to have a significant impact on psychological health conditions and/or traumatic brain injury (TBI) through clinical applications, including health care products, technologies and/or practice guidelines.

Amount: $2,100,000 (Level 1); $4,100,000 (Level 2)

Due Date: 07/13/2026 (Pre-Applications); 10/15/2026 (Full Proposals)

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This program supports research on STEM education in one or more of three research areas: STEM learning and learning environments, broadening participation in STEM, and STEM workforce development.

Amount: $500,000 (Level I); $1,500,000 (Level II); $2,500,000 (Level III)

Due Date: 10/01/2026

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