The purpose of this NOFO is to leverage NICHD clinical research network infrastructure relevant to infants, children, women, including those who are pregnant and lactating, and persons with disabilities to conduct innovative, multisite, investigator-initiated clinical trials and observational studies.
Amount: $9,500,000
Due Date: 11/13/2026; 03/15/2027
This NOFO invites applications that combine computational and experimental approaches to enable rigorous preclinical testing of drugs or drug combinations currently used for other conditions, as well as investigational drugs at various stages of clinical development, predicted to be efficacious in Alzheimer’s Disease (AD) and AD-related dementias (ADRD).
Amount: $7,600,000
Due Date: 02/08/2027
This program supports transitioning teams from research that is multidisciplinary to research that transcends disciplinary boundaries with novel conceptual frameworks, theories and methods.
Amount: $3,600,000
Due Date: 02/08/2027
This program supports use-inspired research, translational activities and partnerships that turn scientific discoveries into real-world solutions. Researchers can gain market insights, launch commercial applications and/or facilitate industry adoption.
Amount: $1,200,000 (TTP-T); $2,000,000 (TTP-P)
Due Date: 11/17/2026
This program aims to stimulate progress on fundamental scientific questions of major importance in mathematics, theoretical physics and theoretical computer science. A Simons Collaboration in MPS should address a mathematical or theoretical topic of fundamental scientific importance, where a significant, new development creates a novel area for exploration or provides a new direction for progress in an established field.
Amount: $8,000,000
Due Date: 10/29/2026 (LOI); 02/25/2027 (Invited Full Proposals)
Through this grant program, IES supports state agencies’ use of their statewide longitudinal data systems (SLDSs) to provide evidence for their own program and policy decisions, and those of their local education agencies regarding increasing learners’ access to high-quality education and increased academic achievement.
Amount: $1,200,000
Due Date: 10/01/2026
This program supports groups of two or more scholars increasing humanistic knowledge through the preparation of a manuscript for print publication, the creation of a scholarly digital project, or the planning of an international collaboration. Projects must pursue significant research questions and lead toward an interpretive product. This year’s competition is limited to projects on American history and culture or Western civilization.
Amount: $50,000 (Planning); $250,000 (Manuscript Preparation or Scholarly Digital Project)
Due Date: 09/16/2026
The purpose of this NOFO is to catalyze the translation of Artificial Intelligence (AI)-enabled, image-centered, multimodal CDS tools, developed as Software as a Medical Device, from training and testing of prototypes towards clinical applications that address unmet health challenges in precision medicine. These projects are expected to have high potential for demonstrable, positive impact on patient outcomes and/or healthcare processes.
Amount: $5,928,000
Due Date: 10/19/2026
The purpose of this NOFO is to solicit applications for the creation of a Validation Center to serve as a dedicated hub for the comprehensive evaluation and characterization of AI-enabled, image-based, multimodal clinical decision support tools developed by the PRIMED-AI Consortium, to ensure these tools are reliable, reproducible, and generalizable.
Amount: $22,496,000
Due Date: 10/02/2026
The purpose of this program supports collaborative teams who edit, annotate, and translate foundational humanities texts that are vital to generating new scholarship but are not available in adequate editions or translations. This year’s competition is limited to projects on American history and culture or Western civilization. Applications must focus on topics in the history and culture of the United States in any period from the Colonial Era to the present, or topics in Western civilization from antiquity to the present.
Amount: $65,000 (Planning); $450,000 (Implementation)
Due Date: 09/16/2026
