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This initiative aims to advance mathematics learning and education through purposeful collaboration that draws on the interdisciplinary Science of Learning (including neuroscience; cognitive, developmental, and social sciences; computer science; machine learning; engineering; and education research), deep experiences in education practice and teaching, and innovations in the use of data science, AI and technology.

Amount: $1,500,000

Due Date: 01/09/2026 (Phase I LOI); 03/11/2026 (Phase I Full Proposals)

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This program supports individual investigators who propose novel research projects with the potential to innovatively and creatively address new areas of fundamental or applied research, catalyze development of new industries or capabilities that increase the leadership position for the country, and/or make significant progress towards addressing a national need or grand challenge.

Amount: Up to $3,000,000

Due Date: 01/20/2026 (LOI); 03/10/2026 (Pre-Proposal)

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Centers supported by this program provide support for special colonies of laboratory animals and associated services, as well as other resources such as informatics tools, reagents, cultures (cells, tissues, and organs) and genetic stocks that serve the biomedical research community in a variety of research areas on a local, regional, and national basis.

Amount: Unspecified

Due Date: 02/18/2026; 05/27/2026

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This program will make funds available to advance transformational collaborative projects that will provide new insights into disease mechanisms or create or implement tools and technologies not previously applied to Huntington’s disease (HD) research for the advancement of therapeutics.

Amount: $600,000 – $1,000,000

Due Date: 01/15/2026 (LOI); 04/30/2026 (Invited Full Proposals)

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This program supports long-term, multi-institutional research with the potential to transform computer and information science and engineering.

Amount: Up to $15,000,000

Due Date: 06/22/2026 (Pre-Proposals)

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This program invites applications for centers to support transdisciplinary teams of clinical and mental health services researchers, behavioral scientists, social scientists, health information and communications technologists, health systems engineers, decision scientists, and mental health stakeholders to engage in high-impact studies that will significantly advance clinical practice and generate knowledge that will fuel transformation of mental health care in the United States.

Amount: $11,325,000

Due Date: 05/18/2026

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This program aims to accelerate biomanufacturing equipment and process innovation, digital transformation, next generation therapies, and commercial adoption all at once focused on accelerating innovation in the manufacture, testing, and release of RNA-containing modalities.

Amount: Unspecified

Due Date: 12/19/2025 (Solution Summaries); 02/27/2026 (Full Proposals)

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This program supports research on the discovery and development of interventions to prevent and/or treat substance use disorders (SUDs) and overdose, including interventions to treat co-morbid SUDs. This includes preclinical and clinical research studies that will have high impact and quickly yield the necessary results to advance candidate interventions closer to regulatory approval or clinical adoption.

Amount: $22,650,000

Due Date: 10/20/2025; 02/20/2026

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This program supports interdisciplinary, collaborative, and highly synergistic projects that focus on the molecular understanding of human lupus and the heterogeneity of the disease. Successful teams will push the boundaries of innovation and bridge research and clinical efforts in lupus by using cutting-edge technologies to address critical questions that could bring about breakthroughs in lupus care, research, or drug development.

Amount: $3,000,000

Due Date: 09/30/2025 (LOI); 03/16/2026 (Invited Full Proposals)

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