This program encourages applications for support of resources that will provide access to state-of-the-art equipment, technologies, research tools, materials, organisms, software, and/or services to a substantial regional (multi-state) or national user base. Only those resources with technical capabilities that fall within the NIGMS-supported program areas are eligible for awards.
Amount: Unspecified
Due Date: 09/25/2025
This program supports interdisciplinary, collaborative, and highly synergistic projects that focus on the molecular understanding of human lupus and the heterogeneity of the disease. Successful teams will push the boundaries of innovation and bridge research and clinical efforts in lupus by using cutting-edge technologies to address critical questions that could bring about breakthroughs in lupus care, research, or drug development.
Amount: $3,000,000
Due Date: 09/30/2025 (LOI); 03/16/2026 (Invited Full Proposals)
This program funds targeted research to uncover novel features of classic Hairy Cell Leukemia (HCL) biology, understand the distinguishing features of HCL variant and apply that knowledge in the clinic, translate new medical knowledge to clinical application, test novel treatments in patients through clinical trials, and apply the HCL registry created by HCLF to examine long-term outcomes and quality of life.
Amount: $2,500,000
Due Date: 09/03/2025 (LOI); 11/21/2025 (Invited Full Applications)
This program supports collaborative teams who are editing, annotating, and translating foundational humanities texts that are vital to generating new scholarships but are inaccessible or only available in inadequate editions or translations. Works from any humanities field may be the subject of an edition.
Amount: $65,000 (Planning); $300,000 (Implementation)
Due Date: 09/29/2025 (Optional Draft); 12/03/2025 (Full Proposal)
This program aims to stimulate progress on fundamental scientific questions of major importance in mathematics, theoretical physics and theoretical computer science. Proposals should address a mathematical or theoretical topic of fundamental scientific importance, where a significant, new development creates a novel area for exploration or provides a new direction for progress in an established field.
Amount: $8,000,000
Due Date: 10/29/2025 (LOI)
This program supports promising research that has high potential to lead to or make breakthroughs in breast cancer.
Amount: Ranges from $750,000 to $3,350,000
Due Date: 08/27/2025 (Pre-Application); 09/10/2025 (Full Application)
This program aims to extend or expand the data collection, follow-up, and analysis of breast cancer clinical studies. The intent of this award mechanism is to increase the clinically relevant impact of breast cancer patient participation in clinical research by addressing the knowledge lost due to early trial termination, limited patient follow-up, or suboptimal sample and/or data collection and analysis.
Amount: $7,000,000 (Single PI); $8,400,000 (Partnering PI Option)
Due Date: 08/27/2025 (Pre-Application); 09/10/2025 (Full Application)
This program supports research on engineered systems with a seamless integration of cyber and physical components, such as computation, control, networking, learning, autonomy, security, privacy and verification, for a range of application domains.
Amount: $1,200,001 – $7,000,000 (FRONTIER Proposals)
Due Date: 08/14/2025 – 08/28/2025 (FRONTIER Proposals)
This program supports individual scientists of exceptional creativity who propose bold and highly innovative research projects with the potential to produce a major impact on broad, important areas relevant to NIH’s mission. The proposed research must reflect substantially different scientific directions from those already being pursued in the investigator’s research program or elsewhere. Applications in all topics relevant to NIH’s mission are welcome, including, but not limited to, topics in the behavioral, social, biomedical, applied, and formal sciences and topics that may involve basic, translational, or clinical research.
Amount: $5,285,000
Due Date: 09/09/2025
Amount: Up to $300,000,000
Due Date: 09/05/2025
This program seeks to establish a Cooperative Institute that will advance key goals in aquaculture, fostering innovation, promoting environmental stewardship, and building strong coastal economies; support the robust development of aquaculture in the United States to address the seafood import deficit and benefit the economy; and help the agency fulfill the tenets of the NOAA Aquaculture Strategic Plan.
