This program seeks to advance therapeutic development through pre-clinical and/or clinical testing of approaches addressing unmet needs of people with Parkinson’s disease (PD). The program is set up to benefit therapeutics with clear potential to prevent, stop, or delay disease progression or to reduce the burden of daily symptoms.
Amount: Pre-Proposals Accepted Any Time; 10/09/2025 (Invited Full Proposals)
Due Date: $250,000 – $2,000,000
This funding opportunity supports prospective or retrospective, efficient, and innovative natural history studies with a focus on collaborative and standardized approaches to ensure data quality and interpretability.
Amount: $1,600,000 (Prospective Studies); $300,000 (Retrospective Studies)
Due Date: 01/09/2026 (LOI); 02/10/2026 (Full Proposal)
This program supports the development of transformative high-risk, high-reward advances in computer and information science, engineering, mathematics, statistics, behavioral and/or cognitive research to address pressing questions in the biomedical and public health communities.
Amount: $1,200,000
Due Date: 10/03/2025
Gateway funds Phase I and II patient-centered cancer clinical trials that have the potential to shift the paradigm for standard of care. This program funds early phase clinical trials for cancers of all types at institutions around the world. These grants are typically 2-5 years in duration.
Amount: Typically$200,000 – $1,500,000
Due Date: 11/05/2025 (LOI)
This funding opportunity supports clinical trials of orphan products in all phases of product development (phase 1, 2 and/or 3) for rare diseases with unmet medical needs. These clinical trials should evaluate safety and/or efficacy of medical products in support of a new indication or a change in labeling.
Amount: $2,600,000
Due Date: 09/22/2025 (LOI); 10/21/2025 (Full Proposal)
This program encourages applications for support of resources that will provide access to state-of-the-art equipment, technologies, research tools, materials, organisms, software, and/or services to a substantial regional (multi-state) or national user base. Only those resources with technical capabilities that fall within the NIGMS-supported program areas are eligible for awards.
Amount: Unspecified
Due Date: 09/25/2025
This program supports interdisciplinary, collaborative, and highly synergistic projects that focus on the molecular understanding of human lupus and the heterogeneity of the disease. Successful teams will push the boundaries of innovation and bridge research and clinical efforts in lupus by using cutting-edge technologies to address critical questions that could bring about breakthroughs in lupus care, research, or drug development.
Amount: $3,000,000
Due Date: 09/30/2025 (LOI); 03/16/2026 (Invited Full Proposals)
This program funds targeted research to uncover novel features of classic Hairy Cell Leukemia (HCL) biology, understand the distinguishing features of HCL variant and apply that knowledge in the clinic, translate new medical knowledge to clinical application, test novel treatments in patients through clinical trials, and apply the HCL registry created by HCLF to examine long-term outcomes and quality of life.
Amount: $2,500,000
Due Date: 09/03/2025 (LOI); 11/21/2025 (Invited Full Applications)
This program supports collaborative teams who are editing, annotating, and translating foundational humanities texts that are vital to generating new scholarships but are inaccessible or only available in inadequate editions or translations. Works from any humanities field may be the subject of an edition.
Amount: $65,000 (Planning); $300,000 (Implementation)
Due Date: 09/29/2025 (Optional Draft); 12/03/2025 (Full Proposal)
