Research Matters

Large Grant Opportunities

Sign up for the large grant opportunities and limited submissions listserv. The Office of Research hosts a listserv that shares large funding opportunities and internal competition announcements weekly as well as a calendar of current limited submissions opportunities.

NSF: Principles and Practice of Scalable Systems (PPoSS) Wednesday, October 21, 2020 - The aim of this program is to support a community of researchers who will work symbiotically across the multiple disciplines above to perform basic research on scalability of modern applications, systems, and toolchains.
NIH: Collaborative Approaches to Engineer Biology for Cancer Applications (U01 Clinical Trial Not Allowed) Wednesday, October 21, 2020 - This FOA supports applications from transdisciplinary teams that develop and apply innovative synthetic biology approaches to address challenges across the spectrum of cancer research.
NIH: Integrative Neuroscience Initiative on Alcoholism (INIA) Consortia Research Resource (U24) (Clinical Trial Optional) Friday, October 16, 2020 - This FOA solicits Research Resources applications to provide resource and technological support to the administrative resource cores and the individual research projects within each of the two INIA consortia.
DOE: Connected Communities Friday, October 16, 2020 - Under this FOA, DOE will select a portfolio of “Connected Community” projects to find and share technical and market solutions that will increase demand flexibility and energy efficiency.
NIH: New Cohorts for Environmental Exposures and Cancer Risk (CEECR) Coordinating Center (U24 Clinical Trial Not Allowed) Friday, October 16, 2020 - The goal of the CEECR is to support innovative scientific research in new prospective cohorts to address knowledge gaps between environmental exposures and cancer etiology, and the genetic, lifestyle, and behavioral factors that modify risk across diverse populations.
Limited Submission: A Multidisciplinary Approach to Study Vaccine-elicited Immunity and Efficacy against Malaria (U01 Clinical Trial Not Allowed) Friday, October 9, 2020 - The purpose of this initiative is to support research to advance understanding of the underlying immune mechanisms that contribute to malaria vaccine-elicited protection or vaccine hypo-responsiveness in endemic regions.
NSF: Mid-scale Research Infrastructure-1 (Mid-scale RI-1) Thursday, October 8, 2020 - The NSF Mid-scale Research Infrastructure-1 Program supports the design or implementation of unique and compelling RI projects.
NIH: Cohort Studies To Improve Our Understanding of Influenza Immunity, Vaccine Response and Effectiveness in Older Adults (65 years and older) (U01 Clinical Trial Not Allowed) Friday, October 2, 2020 - This initiative will support the use of longitudinal cohorts to develop greater understanding of important elements of influenza immunity that impact vaccine response and vaccine effectiveness in older adults.
DOE: FY 2021 Continuation of Solicitation for the Office of Science Financial Assistance Program Friday, October 2, 2020 - The Office of Science of the DOE hereby announces its continuing interest in receiving grant applications for support of work in the following program areas: Advanced Scientific Computing Research, Basic Energy Sciences, Biological and Environmental Research, Fusion Energy Sciences, High Energy Physics, Nuclear Physics, Isotope R&D and Production, and Accelerator R&D and Production.
Limited Submission: Emerging Infections Network – Research for Preventing, Detecting, and Managing Travelers who Acquire Infectious Diseases Abroad Friday, October 2, 2020 - The purpose of this program is to support research activities that will assist with the prevention, detection, and management of international travelers who become ill during or after travel.
Limited Submission: Monitoring Cause-specific School Absenteeism for Estimating Community-wide Influenza and SARS-CoV-2 Transmission Friday, October 2, 2020 - The purpose program is to support a research project that implements an influenza-like illness-specific student absentee monitoring system in K-12 schools and assess its usability for early detection of influenza, SARS-CoV-2, and other respiratory pathogen transmission in schools and surrounding communities.
NIH: Drug Development Collaboratory (UG3/UH3 Clinical Trial Required) Friday, September 25, 2020 - The purpose of this FOA is to support intramural-extramural collaborations on late-stage translational science projects between NCATS Therapeutic Development Branch and extramural researchers, for therapeutic development of small molecules, biologics, or gene therapies.
DOE: Energy and Carbon Optimized Synthesis for the Bioeconomy (ECOSynBio) Friday, September 11, 2020 - This funding opportunity seeks submissions to establish new technologies to significantly improve the carbon efficiency of bioconversion platforms through the accommodation of external reducing equivalents.
NIH: NEI Audacious Goals Initiative: Translation-Enabling Models to Evaluate Survival and Integration of Regenerated Neurons in the Visual System (U24 Clinical Trial Not Allowed) Friday, September 11, 2020 - The National Eye Institute intends to advance the Audacious Goals Initiative by soliciting applications for projects using in vivo models for translation-enabling research related to neural regeneration in the visual system.
NIH: Advanced Laboratories for Accelerating the Reach and Impact of Treatments for Youth and Adults with Mental Illness (ALACRITY) Research Centers (P50 Clinical Trial Optional) Friday, September 11, 2020 - Supports the rapid development, testing, and refinement of novel and integrative approaches for (1) optimizing the effectiveness of therapeutic or preventive interventions for mental disorders within well-defined target populations; (2) organizing and delivering optimized mental health services within real world treatment settings; and (3) continuously improving the quality, impact, and durability of optimized interventions and service delivery within diverse care systems.
(OPEN) Limited Submission: Advanced Computing Systems & Services: Adapting to the Rapid Evolution of Science and Engineering Research Wednesday, September 9, 2020 - Accepts proposals from organizations willing to serve as service providers within the NSF Innovative High-Performance Computing program to provide advanced cyberinfrastructure capabilities and/or services in production operations to support the full range of computational- and data-intensive research across all of science and engineering.
NIH: Centers to Advance Research in Endometriosis (CARE) (P01 Clinical Trial Not Allowed) Friday, September 4, 2020 - The purpose of this FOA is to support the novel development of Centers to Advance Research in Endometriosis (CARE).
NIH: HIV Vaccine Research and Design (HIVRAD) Program (P01 Clinical Trial Not Allowed) Friday, September 4, 2020 - The purpose of this FOA is to support multi-component, multi-disciplinary projects that address scientific questions relevant to AIDS prophylactic vaccine discovery research.
(OPEN) Limited Submission: National Artificial Intelligence (AI) Research Institutes Friday, September 4, 2020 - The National AI Research Institutes program will fund Institutes comprising scientists, engineers, and educators united by a common focus on advancing the research frontiers in AI.
NSF: Advancing Informal STEM Learning (AISL) Tuesday, September 1, 2020 - This program seeks to advance new approaches to and evidence-based understanding of the design and development of STEM learning opportunities for the public in informal environments; provide multiple pathways for broadening access to and engagement in STEM learning experiences; advance innovative research on and assessment of STEM learning in informal environments; and engage the public of all ages in learning STEM in informal environments.
NSF: Focused Research Hubs in Theoretical Physics Thursday, August 27, 2020 - Hubs are designed to enhance significant breakthroughs at an intellectual frontier of physics by providing resources beyond those available to individual investigators, so as to promote a collaborative approach to a focused topic while promoting the preparation of scientists at the beginning of their independent scientific careers.
NIH: Glioblastoma Therapeutics Network (U19 Clinical Trial Required) Thursday, August 27, 2020 - The goal of this FOA is to improve the treatment of adult glioblastoma (GBM) by developing novel effective agents that can cross the blood-brain barrier (BBB) and testing them in the clinic.
(OPEN) Limited Submission: Collaborative Program Grant for Multidisciplinary Teams (RM1 – Clinical Trial Optional) Thursday, August 27, 2020 - This FOA is designed to support highly integrated research teams of 3 to 6 PDs/PIs to address ambitious and challenging research questions that are important for the mission of NIGMS and are beyond the scope of one or two investigators.
Limited Submission: NIOSH Centers of Excellence for Total Worker Health® (U19) Thursday, August 27, 2020 - The purpose of this FOA is to develop and conduct a broad range of multidisciplinary research, intervention, outreach and education, and evaluation activities that advance the overall safety, health, and well-being of the diverse population of workers in our nation.
NSF: Biology Integration Institutes Friday, August 21, 2020 - The aim of this solicitation is to bring researchers together around the common goal of understanding how the processes that sustain life and enable biological innovation operate and interact within and across different scales of organization.
NIH: Disseminating and Implementing Patient-Centered Outcomes Research (PCOR) Evidence into Practice through Interoperable Clinical Decision Support Friday, August 21, 2020 - This FOA invites applications that disseminate and implement patient-centered outcomes research evidence into clinical practice through clinical decision support.
NIH: Grand Opportunity in Medications Development for Substance-Use Disorders (U01 – Clinical Trial Optional) Friday, August 14, 2020 - The purpose of this FOA is to accelerate the development of medication for the treatment of Substance Use Disorders (SUDs) by encouraging research applications to support a diverse array of preclinical and/or clinical research projects.
NIH: BRAIN Initiative: Data Archives for the BRAIN Initiative (R24 Clinical Trial Optional) Friday, August 14, 2020 - This FOA solicits applications to develop web-accessible data archives to capture, store, and curate data related to BRAIN Initiative activities.
FY2021 Vannevar Bush Faculty Fellowship Friday, July 10, 2020 - This FOA seeks distinguished researchers for the purpose of conducting innovative basic research in areas of interest to the DoD and fostering long-term relationships between the VBFF Fellows and the DoD.
Tobacco Use and HIV in Low and Middle-Income Countries (U01 Clinical Trial Optional) Friday, July 10, 2020 - This FOA supports the development and evaluation of tobacco cessation interventions tailored to HIV-positive populations, including those with comorbidities such as tuberculosis (TB), in low-resource settings in low- and middle-income countries.
Limited Submission: Continuation of the Human Pancreas Analysis Program (HPAP) for Type 1 Diabetes (HPAP-T1D) (U01 Clinical Trial Not Allowed) Friday, July 10, 2020 - This FOA will support one team of investigators with combined expertise in human pancreas physiology and pathophysiology; collection, processing and multimodal analysis of human pancreatic tissues; and biological database building, curation and management.
Network of the National Library of Medicine Evaluation Center (U24) (Clinical Trial Not Allowed) Monday, July 6, 2020 - The NNLM Evaluation Center (NEC) will coordinate the assessment of the impact, efficacy and value of NNLM activities, services, and resources. A special focus will be placed on assessing community engagement and measuring its impact on persons who experience health disparities, and populations underrepresented in biomedical research.
Technical Assistance and Dissemination to Improve Services and Results for Children with Disabilities and Demonstration and Training Programs Monday, July 6, 2020 - The purpose of the program is to promote academic achievement and to improve results for children with disabilities by providing TA, supporting model demonstration projects, disseminating useful information, and implementing activities that are supported by scientifically based research.
Pediatric Biospecimen Procurement Center (BPC) Supporting the Developmental Gene Expression (dGTEx) Project (U24 Clinical Trial Not Allowed) Monday, July 6, 2020 - The purpose of this funding opportunity is for support of a Biospecimen Procurement Center (BPC) to enroll suitable pediatric donors and provide high quality tissue samples for analyses to the Laboratory, Data Analysis, and Coordinating Center.
Laboratory, Data Analysis, and Coordinating Center (LDACC) for the Developmental Genotype-Tissue Expression Project(U24) (Clinical Trial Not Allowed) Monday, July 6, 2020 - The LDACC will perform 2 major functions: a molecular laboratory to process tissue samples for sequencing and biobanking, and a data analysis and coordinating center to ensure coordination, monitor study progress and laboratory performance, perform basic analysis of data for gene expression analyses, and harmonize and submit datasets to be deposited in repositories such as the AnVIL (Analysis, Visualization, and Informatics Lab-space).
NIH: Hybrid Effectiveness-Implementation Trials for Heart, Lung, Blood, and Sleep Diseases in the Inpatient Setting (U01 – Clinical Trials Required) Friday, June 19, 2020 - This FOA supports hybrid effectiveness-implementation trials for heart, lung, blood, and sleep (HLBS) diseases in the inpatient setting and applications that propose a multidisciplinary research team that includes expertise in inpatient clinical research, implementation research, and biostatistics.
NIH: NIDA Avant-Garde Award Program for HIV/AIDS and Substance Use Disorder Research (DP1, Clinical Trial Optional) Friday, June 5, 2020 - Supports exceptionally creative scientists, who propose high-impact research that will open new areas of HIV/AIDS research in the context of substance use disorders and/or lead to new avenues for prevention and treatment of HIV/AIDS in people who use drugs.
NIH: Regenerative Medicine Innovation Project (RMIP) Investigator-Initiated Clinical Trials (UG3/UH3 Clinical Trial Required) Friday, June 5, 2020 - Seeks meritorious clinical trials proposing to explore and enable the development of safe and effective regenerative medicine interventions using adult stem cells.
DoD Peer Reviewed Alzheimer’s, Accelerating Diagnostics for Traumatic Brain Injury Research Award Friday, May 22, 2020 - Supports high-impact, human-based development of robust diagnostic and/or prognostic biomarkers for chronic TBI as they pertain to AD/ADRD.
NSF: Discovery Research PreK-12 (DRK-12) Wednesday, May 13, 2020 - This program seeks to significantly enhance the learning and teaching of science, technology, engineering, mathematics and computer science by preK-12 students and teachers.
NIH: Coordinating Unit to Support the Kidney, Urology and Hematology (KUH) Innovative Science Accelerator Program (ISAC-CU) (U24 Clinical Trial Not Allowed) Friday, May 8, 2020 - The purpose of this FOA is to establish a Coordinating Unit to support the Kidney, Urology and Hematology Innovative Science Accelerator Program.
NIH: Implementation Research to Improve Case Finding, Cascade Screening, and Treatment for Familial Hypercholesterolemia (FH) (R61/R33 Clinical Trial Required) Friday, April 17, 2020 - The goal of this program is to support applications that develop and test innovative strategies for accelerating the uptake and sustainment of evidence-based detection, diagnosis, and treatment of adults with familial hypercholesterolemia (FH).
NIH: New Informatics Tools and Methods to Enhance U.S. Cancer Surveillance Research (U01 Clinical Trial Optional) Friday, April 17, 2020 - The goal of this FOA is to advance surveillance science by supporting the development of new and innovative tools and methods for more efficient, detailed, timely, and accurate data collection by cancer registries.
PCORI funding announcement opening moved to cycle 3 Friday, March 27, 2020 - PCORI funding announcement opening moves to June 9.
Limited Submission: Asthma and Allergic Diseases Cooperative Research Centers (U19 Clinical Trial Optional) Friday, March 27, 2020 - The purpose of this FOA is to invite applications from single institutions or consortia of institutions to participate in the Asthma and Allergic Diseases Cooperative Research Centers (AADCRC) program.
NIH: National Cooperative Drug/Device Discovery/Development Groups (NCDDG) for the Treatment of Mental or Substance Use Disorders or Alcohol Disorder (U19 Clinical Trial Optional) Friday, February 28, 2020 - This FOA encourages applications to advance the discovery, preclinical development, and proof of concept testing of new, rationally based candidate agents and neurostimulation approaches to treat mental disorders, substance use disorders or alcohol use disorders, and to develop novel ligands and circuit-engagement devices as tools to further characterize existing or to validate new drug/device targets.
NIH: Network for Identification, Evaluation, and Tracking of Older Persons with Superior Cognitive Performance for Their Chronological Age (U19 Clinical Trial Not Allowed) Friday, February 21, 2020 - This FOA invites applications to establish a network to identify, evaluate, track, and conduct research across multiple sites on older adults with superior cognitive performance for their age.
NEH: Digital Humanities Advancement Grants Friday, November 1, 2019 - These Grants support innovative, experimental, and/or computationally challenging projects at different stages throughout their lifecycles, from early start-up phases through implementation and sustainability.
NEH: Digital Humanities Advancement Grants Wednesday, April 24, 2019 - DHAG supports digital projects at different stages throughout their lifecycles, from early start-up phases through implementation and sustainability.
NSF: Sustained Availability of Biological Infrastructure Monday, April 1, 2019 - The SABI supports the continued operation of extant infrastructure that will advance basic biological research.