Research Matters

Large Grant Opportunities

Sign up for the large grant opportunities and limited submissions listserv. The Office of Research hosts a listserv that shares large funding opportunities and internal competition announcements weekly as well as a calendar of current limited submissions opportunities.

DOE Traineeship in High Energy Physics Instrumentation Monday, April 12, 2021 - The purpose of this funding opportunity announcement (FOA) is to address a workforce shortfall in critical technical topic areas by training graduate students in specific disciplines or sub-disciplines aligned with Science, Technology, Engineering and Mathematics (STEM) workforce needs in the area of instrumentation, particularly as they apply to HEP's mission-space.
NIH: Emergency Award: Social, Behavioral, and Economic Research on COVID-19 Consortium (U01 Clinical Trial Not Allowed) Monday, April 12, 2021 - The purpose of this funding opportunity announcement is to advance research on the impact of SARS-CoV-2 and associated mitigation efforts on individual, family, and community behavior and on how subsequent economic disruption affects health-related outcomes, with close attention to underserved and vulnerable populations.
NIH: Directors Pioneer Award Program (DP1 Clinical Trial Optional) Monday, April 12, 2021 - The NIH Directors Pioneer Award Program supports individual scientists of exceptional creativity who propose highly innovative and potentially transformative research towards the ultimate goal of enhancing human health.
DOC: CDDRR Capacity Development for Weather, Water, and Climate Forecasting and Disaster Risk Reduction Thursday, April 8, 2021 - The CDDRR program’s goal is to improve the performance of all operational meteorological hydrological, and disaster/emergency management services worldwide. Improving agencies’ performance for enhanced decision support services is done through collaboration between operational hydrologists/meteorologists, scientists, and other staff with expertise across a wide range of environmental, economic, and social and behavioral sciences.
NIH: Understanding HIV Reservoir Dynamics (P01, Clinical Trial Not Allowed) Thursday, April 8, 2021 - The purpose of this FOA is to support multi-disciplinary, Program Project applications aimed at understanding changes in the HIV reservoir over time in different cell types and tissues. A better understanding of the mechanisms that govern HIV reservoir dynamics over time is essential to inform the development of strategies to cure HIV or control viral infection to overcome the need for life-long antiretroviral therapy.
NIH: Proteome Characterization Centers (PCCs) for Clinical Proteomic Tumor Analysis Consortium (U24 Clinical Trial Not Allowed) Thursday, April 8, 2021 - This program will 1) support an increased understanding of cancer through comprehensive proteogenomic approaches, 2) expand support for the development of novel cancer diagnostics and therapeutics by implementing proteogenomic strategies to understand drug response and development of resistance in the context of a clinical trial, and 3) accelerate its translation through public resources (such as data, assays, images and reagents) that catalyze hypothesis-driven science.
NIH: Comprehensive Alcohol Research Centers (P60 Clinical trial Optional) Thursday, April 8, 2021 - This FOA invites applications for Comprehensive Alcohol Research Centers using the P60 mechanism which requires a dissemination core to initiate and expand community education related to the activities of the center.
NIH: NINDS Program Project Grant (P01 Clinical Trial Optional) Thursday, April 8, 2021 - This FOA is issued by the National Institute of Neurological Disorders and Stroke to enable submission of program project grant applications that propose to conduct innovative, interactive research to answer significant scientific questions that are important for the mission of NINDS, via a synergistic collaboration between outstanding scientists who might not otherwise collaborate.
DOE: University-based Energy Industry Research and Development of Scalable Cyber-physical Solutions Thursday, April 8, 2021 - This FOA seeks to improve the cyber and cyber-physical security posture of the electric sector through the integration of the DOE Cybersecurity Roadmap Vision statement of ensuring that resilient energy delivery systems are designed, installed, operated, and maintained to survive a cyber incident while sustaining critical functions.
DOE: Traineeship in High Energy Physics Instrumentation Thursday, April 8, 2021 - The purpose of this FOA is to address a workforce shortfall in critical technical topic areas by training graduate students in specific disciplines or sub-disciplines aligned with Science, Technology, Engineering and Mathematics (STEM) workforce needs in the area of instrumentation, particularly as they apply to HEP’s mission-space.
NIH: Emergency Award: Social, Behavioral, and Economic Research on COVID-19 Consortium (U01 Clinical Trial Not Allowed) Thursday, April 8, 2021 - The purpose of this FOA is to advance research on the impact of SARS-CoV-2 and associated mitigation efforts on individual, family, and community behavior and on how subsequent economic disruption affects health-related outcomes, with close attention to underserved and vulnerable populations.
NIH: Directors Pioneer Award Program (DP1 Clinical Trial Optional) Thursday, April 8, 2021 - The NIH Directors Pioneer Award Program supports individual scientists of exceptional creativity who propose highly innovative and potentially transformative research towards the ultimate goal of enhancing human health.
NIH: Strategies that Support Global Food Safety (U01) Clinical Trial Not Allowed Monday, April 5, 2021 - This Cooperative Agreement is expected to contribute to the knowledge base of the current state of food safety and its accompanying scientific research to a global audience.
NIH: Transformative Research to Address Health Disparities and Advance Health Equity (U01 Clinical Trial Allowed) Monday, April 5, 2021 - Seeking projects that would have a major impact in developing, implementing, or disseminating innovative and effective interventions to prevent, reduce, or eliminate health disparities and advance health equity.
NIH: Core Centers for Clinical Research (CCCR) (P30)- Clinical Trial Not Allowed Monday, April 5, 2021 - CCCR goals are to advance prevention, diagnosis and treatment of musculoskeletal, rheumatologic, and skin diseases.
NIH: Neural Mechanisms of Force-Based Manipulations: High Priority Research Networks (U24 Clinical Trial Optional) Monday, April 5, 2021 - Soliciting applications that focus on developing resources by refining and testing key concepts that will advance and further support the study of the neurocircuitry of force-based manipulations.
NIH: Strategies that Support Global Food Safety (U01) Clinical Trial Not Allowed Friday, April 2, 2021 - This Cooperative Agreement is expected to contribute to the knowledge base of the current state of food safety and its accompanying scientific research to a global audience, including challenges, risks and emerging food safety trends, and other food safety research based on WHO’s existing network efforts.
NIH: Transformative Research to Address Health Disparities and Advance Health Equity (U01 Clinical Trial Allowed) Friday, April 2, 2021 - This RFA solicits applications to support collaborative investigative teams or individual scientists who propose unusually innovative research projects, which, if successful, would have a major impact in developing, implementing, or disseminating innovative and effective interventions to prevent, reduce, or eliminate health disparities and advance health equity.
NIH: Mechanisms of HIV Resistance to Broadly Neutralizing Antibodies (bNAbs) (U01 Clinical Trial Not Allowed) Thursday, April 1, 2021 - This FOA encourages multidisciplinary teams to characterize mechanisms that impact resistance to HIV broadly neutralizing antibodies and develop strategies to prevent and overcome HIV resistance to bNAbs.
Limited Submission: Flow Battery Systems Manufacturing Thursday, March 25, 2021 - This program seeks proposals for projects that focus on work to develop or improve manufacturing processes for individual flow battery components, followed by collaborative work to integrate those new or improved components into a prototype system with a mid-sized capacity for industrial applications.
Limited Submission: FY 2022 Critical Language Scholarship Program Thursday, March 25, 2021 - The CLS Program is designed to increase the number of Americans who learn critical foreign languages in support of the U.S. foreign policy goals of increasing national security and promoting economic competitiveness.
Limited Submission: Program to Advance the Career Development of Scientists from Diverse Backgrounds Conducting Nutrition, Obesity, Diabetes, and Related Research (U24 Clinical Trial Optional) Thursday, March 25, 2021 - The purpose of this program is to enhance the diversity of the research workforce who are available to successfully compete for independent research funding from NIH in the areas of nutrition, obesity, diabetes, and related conditions.
NIH: Neural Mechanisms of Force-Based Manipulations: High Priority Research Networks (U24 Clinical Trial Optional) Thursday, March 25, 2021 - This proposed initiative solicits applications that focus on developing resources by refining and testing key concepts that will advance and further support the study of the neurocircuitry of force-based manipulations.
NIH: Core Centers for Clinical Research (CCCR) (P30)- Clinical Trial Not Allowed Thursday, March 25, 2021 - The overall goals of the CCCR are to advance prevention, diagnosis and treatment of musculoskeletal, rheumatologic, and skin diseases by developing and fostering the implementation of novel methods, metrics, and outcome measures that address critical existing and emerging clinical research needs.
USAID: Indonesia Integrity Initiative (Integritas) Thursday, March 25, 2021 - The goal of Integritas is to support the Government of Indonesia (GOI) in its corruption prevention efforts through enhancing civic engagement and strengthening a culture of integrity for both the public and private sectors.
Limited Submission: FY2021 Online Professional English Network (OPEN) Program Friday, March 19, 2021 - This program offers foreign English teaching professionals and language learners the opportunity for professional development through high-quality virtual programming.
DOC: NOAA Science Collaboration Program Thursday, March 18, 2021 - The NOAA Science Collaboration Program (NSCP) supports research, programs, projects and other activities related to NOAA’s mission, primarily through collaborations among scientists and professionals in areas of mutual interest across the full spectrum of NOAA sciences.
USDA: RCPP Alternative Funding Arrangement for Federal fiscal year (FY) 2021 Thursday, March 18, 2021 - The Regional Conservation Partnership Program (RCPP) promotes coordination of NRCS conservation activities with partners that offer value-added contributions that expand our collective ability to address on-farm, watershed, and regional natural resource concerns.
DoD: CDMRP PRMRP Focused Program Award Thursday, March 18, 2021 - The PRMRP challenges the scientific and clinical communities to address the FY21 PRMRP Topic Areas with original ideas that foster new directions along the entire spectrum of research and patient care.
NIH: HEAL Initiative: Analgesic Development Initial Translational Efforts [Small Molecules and Biologics] (U19 Clinical Trial Not Allowed) Thursday, March 18, 2021 - The goal of this FOA is to support team-based research projects to develop assays, screening and early optimization work to develop a non-addictive therapeutic to treat pain.
DOE: DOE Traineeship in Accelerator Science and Engineering Thursday, March 18, 2021 - This program provides support to address critical, targeted workforce development in fields of interest to the DOE mission.
DOE: Data Analytics for Autonomous Optimization and Control of Accelerators and Detectors Thursday, March 18, 2021 - Supports research and development efforts directed at data analytics for autonomous optimization and control of accelerators and detectors of relevance to current or next generation NP accelerator facilities and scientific instrumentation.
NIH: Tropical Medicine Research Centers (U01 Clinical Trial Not Allowed) Monday, March 15, 2021 - This FOA solicits research applications focused on the etiology, epidemiology, pathogenesis, clinical manifestations, diagnosis, prevention, treatment and control of select Neglected Tropical Diseases (NTDs) in endemic areas.
DOE: Perceptually Enabled Task Guidance Monday, March 15, 2021 - The Defense Advance Research Projects Agency is soliciting innovative fundamental research proposals in the area of perceptually-enabled task guidance.
DoD: Perceptually Enabled Task Guidance (PTG) Thursday, March 11, 2021 - The goal of this program is to create artificial intelligence technology that knows about physical tasks in real-time and can see what the user sees and hear what the user hears, and as result can catch mistakes, provide relevant information in context, and instruct when necessary.
NIH: Tropical Medicine Research Centers (U01 Clinical Trial Not Allowed) Thursday, March 11, 2021 - This FOA solicits applications focused on the etiology, epidemiology, pathogenesis, clinical manifestations, diagnosis, prevention, treatment and control of select neglected tropical diseases in endemic areas.
NIH: Tropical Medicine Research Centers Coordinating Center (U01 Clinical Trial Not Allowed) Thursday, March 11, 2021 - This FOA solicits applications for a Tropical Medicine Research Centers Coordinating Center (TMRC CC) for the Tropical Medicine Research Centers (TMRC).
NIH: The Midlife in the United States Study – Cognitive and Neurocognitive Precursors of AD/ADRD (U01 Clinical Trial Not Allowed Thursday, March 4, 2021 - The purpose of this program is to solicit an Alzheimer's disease and Alzheimer's disease related dementias (AD/ADRD)-focused U01 that is ancillary to, but integrated with, the Midlife in the United States Study to provide in-depth information to elucidate behavioral, social, psychological and biological pathways of risk and resilience to cognitive decline and AD/ADRD.
NIH: The Midlife in the United States Study (U19 Clinical Trial Not Allowed) Thursday, March 4, 2021 - The purpose of this FOA is to invite an application for the next 6-year cycle of the Midlife in the United States (MIDUS) Study.
NIH: First in Human and Early-Stage Clinical Trials of Novel Investigational Drugs or Devices for Psychiatric Disorders (U01 Clinical Trial Required) Thursday, March 4, 2021 - Supports early stage clinical trials of novel mechanism of action, investigational drugs, or novel neuromodulatory devices for the treatment of psychiatric disorders.
NIH: Cancer Prevention, Detection, Diagnosis, and Treatment Technologies for Global Health (U01 Clinical Trial Optional) Friday, February 26, 2021 - This FOA solicits applications for projects to adapt, apply, and validate existing or emerging technologies into a new generation of user-friendly, low-cost technologies for preventing, detecting, diagnosing, and/or treating cancers in people living in LMICs.
NIH: Early Intervention to Promote Cardiovascular Health of Mothers and Children (ENRICH) Multisite Resource and Coordinating Center (U24 Clinical Trial Required) Friday, February 26, 2021 - This FOA invites applications for a Resource and Coordinating Center for the NIH Early Intervention to Promote Cardiovascular Health of Mothers and Children (ENRICH).
CDC: Capacity Building for Global, Regional, and National Immunization Programs Friday, February 26, 2021 - The purpose of this program is to strengthen capacity and performance of global, regional and national immunization programs in priority countries.
DoD: Amyotrophic Lateral Sclerosis, Therapeutic/Biomarker Pilot Trial Award Friday, February 19, 2021 - This award supports the rapid implementation of clinical trials with the potential to have a significant impact on the treatment or management of ALS.
NSF: Future Manufacturing Friday, February 19, 2021 - Future Manufacturing supports fundamental research and education of a future workforce to overcome scientific, technological, educational, economic and social barriers in order to enable new manufacturing capabilities.
Limited Submission: High-End Instrumentation (HEI) Grant Program (S10 Clinical Trial Not Allowed) Friday, February 12, 2021 - The HEI grant program encourages applications from groups of NIH-supported investigators to purchase or upgrade a single item of high-end, specialized, commercially available instruments or integrated systems.
NSF: Understanding the Rules of Life: Emergent Networks Friday, February 12, 2021 - This program supports projects that take interdisciplinary approaches to better understand emergent networks and their mechanisms, emphasizing projects that cross multiple levels of complexity and/or temporal scales in taxa from anywhere within the tree of life.
Limited Submission: Human Immunology Project Consortium (HIPC) Coordinating Center (U01 Clinical Trial Not Allowed) Friday, February 12, 2021 - The goal of this FOA is to support a Coordinating Center for the Human Immunology Project Consortium (HIPC) program.
Limited Submission: Human Immunology Project Consortium (HIPC) (U19 Clinical Trial Optional) Friday, February 12, 2021 - The purpose of this FOA is to characterize human immune responses/mechanisms elicited by vaccinations, vaccine adjuvants or natural infections by capitalizing on recent advances in immune profiling technologies.
NIH: The Cellular Scale Connectome in Aging and Alzheimers Disease (U01 Clinical Trial Not Allowed) Friday, February 5, 2021 - This FOA promotes the development of a comprehensive characterization of brain circuits susceptible to Alzheimer’s disease-type pathology and neurodegeneration in mouse models of aging and AD.