Research Matters

Large Grant Opportunities

Sign up for the large grant opportunities and limited submissions listserv. The Office of Research hosts a listserv that shares large funding opportunities and internal competition announcements weekly as well as a calendar of current limited submissions opportunities.

NIH: Development of Microbiome-Related Approaches for Diagnosis/Mitigation/Treatment of Radiation Injuries (U01 Clinical Trial Not Allowed) Monday, October 11, 2021 - The purpose of this FOA is to support research that will advance the understanding of how the microbiome affects radiation injury.
DOC: US Marine Life Observations: Coordinated Marine Biodiversity Observation Network (MBON) and Animal Telemetry Network (ATN) Activities to Ensure Resilient, Productive Ecosystems and Human Communities in the Face of Change Monday, October 11, 2021 - This program supports proposals that: (1) build upon the foundation established by MBON, ATN and the US IOOS Regional Associations to work across sectors and disciplines towards an integrated, sustained marine life observing capability for the U.S. ocean, coasts and Great Lakes, from estuaries to the deep ocean.
NIH: Systems Biology for Infectious Diseases (U19 Clinical Trial Not Allowed) Monday, October 11, 2021 - The purpose of the FOA is to support research that employs systems biology approaches to human pathogens.
NIH: SPARC Human Open Research Neural Engineering Technologies (HORNET) Initiative (U41) Monday, October 11, 2021 - This U41 opportunity will fund centers to create interoperable open-source modules that can be combined into custom profiles for new exploratory and clinical neuromodulation studies in the peripheral nervous system, and for potential applicability in the central nervous system.
NIH: Pediatric Obesity Discovery Science Research to Improve Understanding of Risk and Causal Mechanisms for Obesity in Early Life (R01) Monday, October 11, 2021 - The purpose of this FOA is to support innovative, discovery research studies to better characterize early-life risk factors and elucidate underlying causal mechanisms through which these risk factors contribute to the development of obesity during infancy and early childhood.
NSF: Integrative Research in Biology (IntBIO) Saturday, September 25, 2021 - This solicitation invites submission of collaborative proposals that tackle bold questions in biology and require an integrated approach to make substantive progress.
NSF: Cyberinfrastructure for Sustained Scientific Innovation (CSSI) Saturday, September 25, 2021 - This solicitation expands the Cyberinfrastructure for Sustained Scientific Innovation program by adding a new project class: Transition to Sustainability.
NSF: Biology Integration Institutes (BII) Tuesday, September 21, 2021 - The NSF Directorate for Biological Sciences program for Biology Integration Institutes (BII) supports diverse and collaborative teams of researchers investigating questions that span multiple disciplines within and beyond biology.
NSF: EHR Core Research – Resource Coordination Hub (ECR Hub) Monday, September 13, 2021 - NSF seeks proposals to create an EHR Core Research (ECR) Resource Coordination Hub (ECR Hub) that will be an intellectual partner to the ECR:Core and the ECR:BCSER grantee communities and the NSF to enhance the overall influence and reach of ECR STEM education research investments.
DOE: Natural Gas Demand Response Pilot Program Monday, September 13, 2021 - FOA soliciting cooperative agreements for the development of multiple regional natural gas demand response pilot programs in collaboration with utilities, local distribution companies and public utility commissions.
NEH: Digital Humanities Advancement Grants Monday, September 13, 2021 - computationally challenging digital projects, leading to work that can scale to enhance scholarly research, teaching and public programming in the humanities.
NSF: Facility and Instrumentation Request Process (FIRP) Monday, September 13, 2021 - The Facility and Instrumentation Request Process (FIRP) solicitation describes the mechanism by which the research community can propose projects that require access to instrumentation and facilities sponsored by the FARE Program.
NIH: Learning Disabilities Innovation Hubs (P20) Friday, September 3, 2021 - This FOA invites exploratory grant applications addressing the etiology, manifestation, prevention and remediation of reading, writing and/or mathematics specific learning disorders.
NIH: National Cancer Institute Youth Enjoy Science Research Education Program (R25) Friday, September 3, 2021 - This funding opportunity seeks to facilitate the education of students from diverse backgrounds underrepresented in biomedical research who will become knowledgeable about cancer, and available to focus on cancer later in their careers.
NSF: Ecology and Evolution of Infectious Diseases (EEID) Friday, September 3, 2021 - The Ecology and Evolution of Infectious Diseases program supports research on the ecological, evolutionary, organismal and social drivers that influence the transmission dynamics of infectious diseases.
NEH: Collaborative Research Friday, September 3, 2021 - The purpose of this program is to support groups of two or more scholars seeking to increase humanistic knowledge through convenings, research, manuscript preparation for collaborative publications, and the creation of scholarly digital projects.
NSF: Reproducible Cells and Organoids via Directed-Differentiation Encoding (RECODE) Tuesday, August 31, 2021 - Several NSF divisions seek proposals that elucidate mechanisms of, and develop strategies to, direct the differentiation of undifferentiated cells into mature, functional cells or organoids.
NIH: Impact of Technology and Digital Media (TDM) Exposure/Usage on Child and Adolescent Development (P01) Tuesday, August 31, 2021 - This NIH FOA invites submission of Program Project (P01) applications to support integrated, multi-project research programs examining the pathways by which technology and digital media exposure and usage impact developmental trajectories and health outcomes in early childhood and adolescence.
NSF: NSF-Simons Collaboration on a National Institute for Theory and Mathematics in Biology Monday, August 23, 2021 - The purpose of the NSF-Simons Collaboration on a National Institute for Theory and Mathematics in Biology is to support a research institute to enable innovative research at the intersection of mathematical and biological sciences to facilitate new developments of biology-inspired mathematical theories, methodologies and innovative modeling approaches to advance the understanding of challenging biological problems.
NIH: Biomarkers for the Lewy Body Dementias (U01 Clinical Trial Not Allowed) Monday, August 23, 2021 - The purpose of this FOA is to support hypothesis-driven clinical research applications that are focused on discovering novel diagnostic, prognostic and/or therapeutic biomarkers for the Lewy Body Dementias.
NEH: Public Humanities Projects Tuesday, August 17, 2021 - The purpose of this program is to support projects that bring the ideas and insights of the humanities to life for general audiences through in-person programming.
NIH: Effectiveness of Implementing Sustainable Evidence-Based Mental Health Practices in Low-Resource Settings to Achieve Mental Health Equity for Traditionally Underserved Populations (R01 Clinical Trial Optional) Tuesday, August 17, 2021 - This FOA encourages studies that develop and test the effectiveness of strategies for implementation and sustainable delivery of evidence-based mental health treatments and services to improve mental health outcomes for underserved populations in low-resourced settings in the U.S. 
NIH: Research Centers for Cancer Systems Biology (U54 Clinical Trial Not Allowed) Tuesday, August 17, 2021 - The Cancer Systems Biology Consortium includes research centers that should address a well-defined overarching scientific theme that will be pursued through two or three research projects.
NIH: BRAIN Initiative Cell Atlas Network (BICAN): Specialized Collaboratory on Human, Non-human Primate, and Mouse Brain Cell Atlases (U01) Friday, August 6, 2021 - This program intends to support a group of Specialized Collaboratories that will adopt scalable technology platforms and streamlined sampling strategies and assay cascade to create comprehensive and highly granular brain cell atlases in human, non-human primates, and mouse.
NIH: BRAIN Initiative Cell Atlas Network (BICAN): Coordinating Unit for Biostatistics, Informatics, and Engagement (CUBIE) (U24) Friday, August 6, 2021 - This program intends to support a unit to coordinate the research within and beyond the BRAIN Initiative Cell Atlas Network.
DOC: American Rescue Plan Act (ARPA) Statewide Planning, Research and Networks Friday, July 30, 2021 - The ARPA Statewide Planning, Research, and Networks NOFO is part of EDA’s multi-phase effort to respond to the coronavirus pandemic as directed by the American Rescue Plan Act of 2021.
NOAA: Understanding multi-stressor impacts on marine ecosystems under climate change Friday, July 30, 2021 - This opportunity solicits proposals to understand the combined impacts of multiple stressors on the function and health of marine ecosystems within the context of climate change.
NIH: Elucidating the Roles of Transposable Elements in AD/ADRD and Aging (R01 Clinical Trial Not Allowed) Monday, July 26, 2021 - NIH FOA to support hypothesis-driven research to gain an understanding of the dysregulation of transposable elements and their contributions to Alzheimer’s disease and Alzheimer’s disease-related dementias and aging.
NSF: Advancing Informal STEM Learning (AISL) Friday, July 16, 2021 - The Advancing Informal STEM Learning program seeks to advance new approaches to and evidence-based understanding of the design and development of STEM learning opportunities for the public in informal environments.
NIH: Computational Approaches for Validating Dimensional Constructs of Relevance to Psychopathology Friday, July 9, 2021 - Soliciting applications for research projects that will use computational approaches to test the validity of dimensional constructs in the NIMH Research Domain Criteria (RDoC) matrix.
CDC: Vector-Borne Disease Regional Centers of Excellence (Forecasted) Friday, July 9, 2021 - Seeking to improve national capacity to address the growing problem of vector-borne diseases via support for regional Centers of Excellence for vector-borne diseases.
HRSA: Optimizing Momentum Toward Sustainable Epidemic Control Friday, July 9, 2021 - As PEPFAR countries get closer to achieving Epidemic Control, there will be a need for unique solutions in countries seeking to attain and sustain long-term epidemic control, from determining the most effective delivery systems for a particular population, region, or country, to transforming the latest scientific breakthroughs into sustainable service delivery models, improving health workforce capacity and beyond.
NSF: CISE Community Research Infrastructure (CCRI) Tuesday, July 6, 2021 - NSF's CISE Community Research Infrastructure program drives discovery and learning in the core CISE disciplines of the three participating divisions by funding the creation and enhancement of world-class research infrastructure.
NSF: Mathematical Sciences Research Institutes Tuesday, July 6, 2021 - The goals of the Mathematical Sciences Research Institutes program include advancing research in the mathematical sciences, increasing the impact of the mathematical sciences in other disciplines, and expanding the talent base engaged in mathematical research in the United States.
NSF: Centers for Chemical Innovation Thursday, May 27, 2021 - The Centers for Chemical Innovation (CCI) Program supports research centers focused on major, long-term fundamental chemical research challenges. CCIs that address these challenges will produce transformative research, lead to innovation, and attract broad scientific and public interest.
NIH: Emergency Award: Social, Behavioral, and Economic Research on COVID-19 Consortium (U01 Clinical Trial Not Allowed) Monday, April 12, 2021 - The purpose of this funding opportunity announcement is to advance research on the impact of SARS-CoV-2 and associated mitigation efforts on individual, family, and community behavior and on how subsequent economic disruption affects health-related outcomes, with close attention to underserved and vulnerable populations.
NIH: Comprehensive Alcohol Research Centers (P60 Clinical trial Optional) Thursday, April 8, 2021 - This FOA invites applications for Comprehensive Alcohol Research Centers using the P60 mechanism which requires a dissemination core to initiate and expand community education related to the activities of the center.
NIH: Emergency Award: Social, Behavioral, and Economic Research on COVID-19 Consortium (U01 Clinical Trial Not Allowed) Thursday, April 8, 2021 - The purpose of this FOA is to advance research on the impact of SARS-CoV-2 and associated mitigation efforts on individual, family, and community behavior and on how subsequent economic disruption affects health-related outcomes, with close attention to underserved and vulnerable populations.
NIH: The Midlife in the United States Study – Cognitive and Neurocognitive Precursors of AD/ADRD (U01 Clinical Trial Not Allowed Thursday, March 4, 2021 - The purpose of this program is to solicit an Alzheimer's disease and Alzheimer's disease related dementias (AD/ADRD)-focused U01 that is ancillary to, but integrated with, the Midlife in the United States Study to provide in-depth information to elucidate behavioral, social, psychological and biological pathways of risk and resilience to cognitive decline and AD/ADRD.
NIH: The Midlife in the United States Study (U19 Clinical Trial Not Allowed) Thursday, March 4, 2021 - The purpose of this FOA is to invite an application for the next 6-year cycle of the Midlife in the United States (MIDUS) Study.
NSF: Cyber-Physical Systems – Frontier Proposals Friday, January 15, 2021 - The Cyber-physical systems (CPS) program aims to develop the core research needed to engineer complex CPS.
NIH: Grand Opportunity in Medications Development for Substance-Use Disorders (U01 – Clinical Trial Optional) Friday, August 14, 2020 - The purpose of this FOA is to accelerate the development of medication for the treatment of Substance Use Disorders (SUDs) by encouraging research applications to support a diverse array of preclinical and/or clinical research projects.
FY2021 Vannevar Bush Faculty Fellowship Friday, July 10, 2020 - This FOA seeks distinguished researchers for the purpose of conducting innovative basic research in areas of interest to the DoD and fostering long-term relationships between the VBFF Fellows and the DoD.
Tobacco Use and HIV in Low and Middle-Income Countries (U01 Clinical Trial Optional) Friday, July 10, 2020 - This FOA supports the development and evaluation of tobacco cessation interventions tailored to HIV-positive populations, including those with comorbidities such as tuberculosis (TB), in low-resource settings in low- and middle-income countries.
Limited Submission: Continuation of the Human Pancreas Analysis Program (HPAP) for Type 1 Diabetes (HPAP-T1D) (U01 Clinical Trial Not Allowed) Friday, July 10, 2020 - This FOA will support one team of investigators with combined expertise in human pancreas physiology and pathophysiology; collection, processing and multimodal analysis of human pancreatic tissues; and biological database building, curation and management.
Network of the National Library of Medicine Evaluation Center (U24) (Clinical Trial Not Allowed) Monday, July 6, 2020 - The NNLM Evaluation Center (NEC) will coordinate the assessment of the impact, efficacy and value of NNLM activities, services, and resources. A special focus will be placed on assessing community engagement and measuring its impact on persons who experience health disparities, and populations underrepresented in biomedical research.
Technical Assistance and Dissemination to Improve Services and Results for Children with Disabilities and Demonstration and Training Programs Monday, July 6, 2020 - The purpose of the program is to promote academic achievement and to improve results for children with disabilities by providing TA, supporting model demonstration projects, disseminating useful information, and implementing activities that are supported by scientifically based research.
Pediatric Biospecimen Procurement Center (BPC) Supporting the Developmental Gene Expression (dGTEx) Project (U24 Clinical Trial Not Allowed) Monday, July 6, 2020 - The purpose of this funding opportunity is for support of a Biospecimen Procurement Center (BPC) to enroll suitable pediatric donors and provide high quality tissue samples for analyses to the Laboratory, Data Analysis, and Coordinating Center.
Laboratory, Data Analysis, and Coordinating Center (LDACC) for the Developmental Genotype-Tissue Expression Project(U24) (Clinical Trial Not Allowed) Monday, July 6, 2020 - The LDACC will perform 2 major functions: a molecular laboratory to process tissue samples for sequencing and biobanking, and a data analysis and coordinating center to ensure coordination, monitor study progress and laboratory performance, perform basic analysis of data for gene expression analyses, and harmonize and submit datasets to be deposited in repositories such as the AnVIL (Analysis, Visualization, and Informatics Lab-space).
NIH: Hybrid Effectiveness-Implementation Trials for Heart, Lung, Blood, and Sleep Diseases in the Inpatient Setting (U01 – Clinical Trials Required) Friday, June 19, 2020 - This FOA supports hybrid effectiveness-implementation trials for heart, lung, blood, and sleep (HLBS) diseases in the inpatient setting and applications that propose a multidisciplinary research team that includes expertise in inpatient clinical research, implementation research, and biostatistics.