Research Matters

Large Grant Opportunities

Sign up for the large grant opportunities and limited submissions listserv. The Office of Research hosts a listserv that shares large funding opportunities and internal competition announcements weekly as well as a calendar of current limited submissions opportunities.

DOC: American Rescue Plan Act (ARPA) Statewide Planning, Research and Networks Friday, July 30, 2021 - The ARPA Statewide Planning, Research, and Networks NOFO is part of EDA’s multi-phase effort to respond to the coronavirus pandemic as directed by the American Rescue Plan Act of 2021.
NOAA: Understanding multi-stressor impacts on marine ecosystems under climate change Friday, July 30, 2021 - This opportunity solicits proposals to understand the combined impacts of multiple stressors on the function and health of marine ecosystems within the context of climate change.
NIH: Technology Development for Single-Molecule Protein Sequencing and Single-Cell Proteome Analysis (R01 Clinical Trial not allowed) Monday, July 26, 2021 - NIH FOA solicits grant applications to catalyze major advances in single-molecule protein sequencing and single cell proteome analysis through technology development.
NIH: Elucidating the Roles of Transposable Elements in AD/ADRD and Aging (R01 Clinical Trial Not Allowed) Monday, July 26, 2021 - NIH FOA to support hypothesis-driven research to gain an understanding of the dysregulation of transposable elements and their contributions to Alzheimer’s disease and Alzheimer’s disease-related dementias and aging.
EPA: National Priorities: Water Innovation, Science and Engagement to Advance Water Reuse Monday, July 26, 2021 - EPA request for applications is intended to address multiple water reuse sources and applications to support national efforts to reduce technological and institutional barriers for expanded water reuse. 
NSF: Advanced Technological Education (ATE) Friday, July 16, 2021 - The ATE program supports the education of technicians for the high-technology fields that drive our nation's economy.
NSF: Advancing Informal STEM Learning (AISL) Friday, July 16, 2021 - The Advancing Informal STEM Learning program seeks to advance new approaches to and evidence-based understanding of the design and development of STEM learning opportunities for the public in informal environments.
NIH: Computational Approaches for Validating Dimensional Constructs of Relevance to Psychopathology Friday, July 9, 2021 - Soliciting applications for research projects that will use computational approaches to test the validity of dimensional constructs in the NIMH Research Domain Criteria (RDoC) matrix.
NEH: Dialogues on the Experience of War Friday, July 9, 2021 - The Dialogues on the Experience of War program supports the study and discussion of important humanities sources about war, in the belief that these sources can help U.S. military veterans and others think more deeply about the issues raised by war and military service.
CDC: Vector-Borne Disease Regional Centers of Excellence (Forecasted) Friday, July 9, 2021 - Seeking to improve national capacity to address the growing problem of vector-borne diseases via support for regional Centers of Excellence for vector-borne diseases.
HRSA: Optimizing Momentum Toward Sustainable Epidemic Control Friday, July 9, 2021 - As PEPFAR countries get closer to achieving Epidemic Control, there will be a need for unique solutions in countries seeking to attain and sustain long-term epidemic control, from determining the most effective delivery systems for a particular population, region, or country, to transforming the latest scientific breakthroughs into sustainable service delivery models, improving health workforce capacity and beyond.
NSF: CISE Community Research Infrastructure (CCRI) Tuesday, July 6, 2021 - NSF's CISE Community Research Infrastructure program drives discovery and learning in the core CISE disciplines of the three participating divisions by funding the creation and enhancement of world-class research infrastructure.
NIH: Innovative Programs to Enhance Research Training (IPERT) (R25 Independent Clinical Trial Not Allowed) Tuesday, July 6, 2021 - NIH's Innovative Programs to Enhance Research Training (IPERT) initiative will enable the scientific community to develop and implement innovative educational activities to equip diverse cohorts of participants with technical, operational or professional skills required for careers in the biomedical research workforce, by effectively integrating courses for skill development and mentoring activities.
NSF: Mathematical Sciences Research Institutes Tuesday, July 6, 2021 - The goals of the Mathematical Sciences Research Institutes program include advancing research in the mathematical sciences, increasing the impact of the mathematical sciences in other disciplines, and expanding the talent base engaged in mathematical research in the United States.
NIH: Notice of Intent to Publish a Funding Opportunity Announcement for Antiviral Drug Discovery (AViDD) Centers for Pathogens of Pandemic Concern (U19) Tuesday, July 6, 2021 - The National Institute of Allergy and Infectious Diseases intends to publish a funding opportunity announcement to solicit applications to establish Antiviral Drug Discovery Centers for Pathogens of Pandemic Concern.
NSF: Leading Engineering for America’s Prosperity, Health and Infrastructure Monday, June 28, 2021 - The LEAP HI program challenges the engineering research community to take a leadership role in addressing demanding, urgent, and consequential challenges for advancing America’s prosperity, health and infrastructure.
NEH: Humanities Connections Monday, June 28, 2021 - The Humanities Connections program seeks to expand the role of the humanities in undergraduate education at two- and four-year institutions.
DOD: Alcohol and Substance Abuse Disorders Consortium Award Monday, June 21, 2021 - Seeking applications for a Consortium Award to conduct multidisciplinary, team-based translational research efforts to identify promising compounds and conduct preclinical and clinical research to test potential medications or medication combinations in humans with ASUD and comorbid PTSD and other psychological disorders, and to explore precision medicine tools for matching patients to these medications.
CDC: Global Noncommunicable Disease Prevention and Health Promotion Monday, June 21, 2021 - The purpose is to promote health and prevent NCDs across the globe by supporting surveillance, capacity building, and implementation activities that focus on key NCD conditions and risk factors.
CDC: Enhancing Global Health Security: Strengthening Public Health Surveillance Systems and Preparedness Globally Sunday, June 13, 2021 - This NOFO is intended to support global health security partners to develop or continue the implementation of surveillance activities that focus on protecting and improving public health globally through strategic planning, policy, strengthening surveillance capacities and systems through partnerships.
NIH: Non-Human Primate Developmental Genotype-Tissue Expression (NHP dGTEx) Research Center Monday, June 7, 2021 - The purpose of this funding opportunity is to solicit applications for the Non-Human Primate Developmental Genotype-Tissue Expression (NHP dGTEx) Research Center.
NSF: EHR Core Monday, June 7, 2021 - The EHR Core Research (ECR) program invites proposals for fundamental research that contributes to the general, explanatory knowledge that underlies STEM education.
NIH: Non-Human Primate Developmental Genotype-Tissue Expression (NHP dGTEx) Research Center Thursday, June 3, 2021 - The NHP dGTEx Research Center will perform four major functions: 1) create a tissue resource of multiple reference tissues across developmental stages in non-human primates (NHPs); 2) perform transcriptome sequencing and other genomic analysis of single-cell and bulk tissues; 3) analyze gene expression patterns in NHPs and compare them to human gene expression patterns; and 4) make the tissue samples and data available and usable for the research community.
NSF: EHR Core Research Thursday, June 3, 2021 - The EHR Core Research (ECR) program invites proposals for fundamental research (curiosity-driven basic research and use-inspired basic research) that contributes to the general, explanatory knowledge that underlies STEM education in one or more of the three broadly conceived Research Areas: Research on STEM Learning and Learning Environments, Research on Broadening Participation in STEM fields, and Research on STEM Workforce Development.
NSF: Centers for Chemical Innovation Thursday, May 27, 2021 - The Centers for Chemical Innovation (CCI) Program supports research centers focused on major, long-term fundamental chemical research challenges. CCIs that address these challenges will produce transformative research, lead to innovation, and attract broad scientific and public interest.
NIH: Consortium for Innovative HIV/AIDS Vaccine and Cure Research (UM1 Clinical Trial Not Allowed) Tuesday, May 18, 2021 - This FOA supports consortia to conduct research toward the prevention and cure of HIV.
NIH: Consortium for Innovative HIV/AIDS Vaccine and Cure Research (UM1 Clinical Trial Not Allowed) Friday, May 14, 2021 - This FOA supports consortia to conduct research toward the prevention and cure of HIV.
NIH: Kidney Precision Medicine Project Kidney Tissue Atlas Coordinating Center (U01 Clinical Trial Not Allowed) Thursday, April 29, 2021 - This FOA requests applications for the Kidney Precision Medicine Project (KPMP) - Kidney Tissue Atlas Coordinating Center (KTACC). The KTACC will collaborate with the KPMP Recruitment Sites (RS), Tissue Interrogation Sites (TIS), and Central Hub (CH) to obtain and evaluate kidney biopsies from participants with acute kidney injury (AKI) or chronic kidney disease (CKD), create a Kidney Tissue Atlas, define disease subgroups, and identify critical cells, interstitial components, pathways, and targets for novel therapies.
NSF: Robert Noyce Teacher Scholarship Program Monday, April 26, 2021 - The Noyce Program invites innovative proposals that address the critical need for recruiting, preparing and retaining highly effective elementary and secondary mathematics and science teachers and teacher leaders in high-need school districts.
NSF: Robert Noyce Teacher Scholarship Program Friday, April 23, 2021 - The Noyce Program invites innovative proposals that address the critical need for recruiting, preparing, and retaining highly effective elementary and secondary mathematics and science teachers and teacher leaders in high-need school districts.
NSF: Grand Challenges in Integrative Geospace Sciences: Advancing National Space Weather Expertise and Research toward Societal Resilience (ANSWERS) Monday, April 19, 2021 - ANSWERS aims to bring together collaborative teams of solar and geospace observers, theorists, modelers, experimenters, educators and computational experts to address challenging problems in solar and space physics and space weather.
Grand Challenges in Integrative Geospace Sciences: Advancing National Space Weather Expertise and Research toward Societal Resilience (ANSWERS) Thursday, April 15, 2021 - ANSWERS aims to bring together collaborative teams of solar and geospace observers, theorists, modelers, experimenters, educators and computational experts to address challenging problems in solar and space physics and space weather and to advance the nation’s science, technology, engineering, and mathematics (STEM) expertise and build societal resilience against space weather hazards.
NIH: Emergency Award: Social, Behavioral, and Economic Research on COVID-19 Consortium (U01 Clinical Trial Not Allowed) Monday, April 12, 2021 - The purpose of this funding opportunity announcement is to advance research on the impact of SARS-CoV-2 and associated mitigation efforts on individual, family, and community behavior and on how subsequent economic disruption affects health-related outcomes, with close attention to underserved and vulnerable populations.
NIH: Directors Pioneer Award Program (DP1 Clinical Trial Optional) Monday, April 12, 2021 - The NIH Directors Pioneer Award Program supports individual scientists of exceptional creativity who propose highly innovative and potentially transformative research towards the ultimate goal of enhancing human health.
NIH: Comprehensive Alcohol Research Centers (P60 Clinical trial Optional) Thursday, April 8, 2021 - This FOA invites applications for Comprehensive Alcohol Research Centers using the P60 mechanism which requires a dissemination core to initiate and expand community education related to the activities of the center.
NIH: Emergency Award: Social, Behavioral, and Economic Research on COVID-19 Consortium (U01 Clinical Trial Not Allowed) Thursday, April 8, 2021 - The purpose of this FOA is to advance research on the impact of SARS-CoV-2 and associated mitigation efforts on individual, family, and community behavior and on how subsequent economic disruption affects health-related outcomes, with close attention to underserved and vulnerable populations.
NIH: Directors Pioneer Award Program (DP1 Clinical Trial Optional) Thursday, April 8, 2021 - The NIH Directors Pioneer Award Program supports individual scientists of exceptional creativity who propose highly innovative and potentially transformative research towards the ultimate goal of enhancing human health.
NIH: Core Centers for Clinical Research (CCCR) (P30)- Clinical Trial Not Allowed Monday, April 5, 2021 - CCCR goals are to advance prevention, diagnosis and treatment of musculoskeletal, rheumatologic, and skin diseases.
NIH: Core Centers for Clinical Research (CCCR) (P30)- Clinical Trial Not Allowed Thursday, March 25, 2021 - The overall goals of the CCCR are to advance prevention, diagnosis and treatment of musculoskeletal, rheumatologic, and skin diseases by developing and fostering the implementation of novel methods, metrics, and outcome measures that address critical existing and emerging clinical research needs.
NIH: The Midlife in the United States Study – Cognitive and Neurocognitive Precursors of AD/ADRD (U01 Clinical Trial Not Allowed Thursday, March 4, 2021 - The purpose of this program is to solicit an Alzheimer's disease and Alzheimer's disease related dementias (AD/ADRD)-focused U01 that is ancillary to, but integrated with, the Midlife in the United States Study to provide in-depth information to elucidate behavioral, social, psychological and biological pathways of risk and resilience to cognitive decline and AD/ADRD.
NIH: The Midlife in the United States Study (U19 Clinical Trial Not Allowed) Thursday, March 4, 2021 - The purpose of this FOA is to invite an application for the next 6-year cycle of the Midlife in the United States (MIDUS) Study.
NSF: Cyber-Physical Systems – Frontier Proposals Friday, January 15, 2021 - The Cyber-physical systems (CPS) program aims to develop the core research needed to engineer complex CPS.
DOE: FY 2021 Continuation of Solicitation for the Office of Science Financial Assistance Program Friday, October 2, 2020 - The Office of Science of the DOE hereby announces its continuing interest in receiving grant applications for support of work in the following program areas: Advanced Scientific Computing Research, Basic Energy Sciences, Biological and Environmental Research, Fusion Energy Sciences, High Energy Physics, Nuclear Physics, Isotope R&D and Production, and Accelerator R&D and Production.
NIH: Grand Opportunity in Medications Development for Substance-Use Disorders (U01 – Clinical Trial Optional) Friday, August 14, 2020 - The purpose of this FOA is to accelerate the development of medication for the treatment of Substance Use Disorders (SUDs) by encouraging research applications to support a diverse array of preclinical and/or clinical research projects.
FY2021 Vannevar Bush Faculty Fellowship Friday, July 10, 2020 - This FOA seeks distinguished researchers for the purpose of conducting innovative basic research in areas of interest to the DoD and fostering long-term relationships between the VBFF Fellows and the DoD.
Tobacco Use and HIV in Low and Middle-Income Countries (U01 Clinical Trial Optional) Friday, July 10, 2020 - This FOA supports the development and evaluation of tobacco cessation interventions tailored to HIV-positive populations, including those with comorbidities such as tuberculosis (TB), in low-resource settings in low- and middle-income countries.
Limited Submission: Continuation of the Human Pancreas Analysis Program (HPAP) for Type 1 Diabetes (HPAP-T1D) (U01 Clinical Trial Not Allowed) Friday, July 10, 2020 - This FOA will support one team of investigators with combined expertise in human pancreas physiology and pathophysiology; collection, processing and multimodal analysis of human pancreatic tissues; and biological database building, curation and management.
Network of the National Library of Medicine Evaluation Center (U24) (Clinical Trial Not Allowed) Monday, July 6, 2020 - The NNLM Evaluation Center (NEC) will coordinate the assessment of the impact, efficacy and value of NNLM activities, services, and resources. A special focus will be placed on assessing community engagement and measuring its impact on persons who experience health disparities, and populations underrepresented in biomedical research.
Technical Assistance and Dissemination to Improve Services and Results for Children with Disabilities and Demonstration and Training Programs Monday, July 6, 2020 - The purpose of the program is to promote academic achievement and to improve results for children with disabilities by providing TA, supporting model demonstration projects, disseminating useful information, and implementing activities that are supported by scientifically based research.
Pediatric Biospecimen Procurement Center (BPC) Supporting the Developmental Gene Expression (dGTEx) Project (U24 Clinical Trial Not Allowed) Monday, July 6, 2020 - The purpose of this funding opportunity is for support of a Biospecimen Procurement Center (BPC) to enroll suitable pediatric donors and provide high quality tissue samples for analyses to the Laboratory, Data Analysis, and Coordinating Center.