Research Matters

Large Grant Opportunities

Sign up for the large grant opportunities and limited submissions listserv. The Office of Research hosts a listserv that shares large funding opportunities and internal competition announcements weekly as well as a calendar of current limited submissions opportunities.

NIH: Nutrition for Precision Health, powered by the All of Us Research Program: Artificial Intelligence for Multimodal Data Modeling and Bioinformatics Center (U54 Clinical Trial Not Allowed) Friday, January 22, 2021 - This FOA will generate actively learning algorithms to predict human response to different foods, nutrients, food components, and dietary patterns as well as advance understanding of longitudinal dynamics from multimodal data with advanced computer modeling tools.
DOE: Engineering-Scale Testing and Validation of Algae-Based Technologies and Bioproducts Friday, January 22, 2021 - This FOA seeks novel research and development of algae-based technology to utilize anthropogenic CO2 as a feedstock.
DOE: Offshore Wind Energy Environmental Research and Instrumentation Validation Friday, January 22, 2021 - This FOA supports regionally focused, coordinated research efforts to increase understanding of the environmental impacts of offshore wind development as well as to advance and validate technical readiness of tools for monitoring and minimizing impacts.
NSF: Cyber-Physical Systems – Frontier Proposals Friday, January 15, 2021 - The Cyber-physical systems (CPS) program aims to develop the core research needed to engineer complex CPS.
NIH: Immune Development in Early Life (IDEaL) (U19 Clinical Trial Not Allowed) Friday, January 15, 2021 - This FOA supports research to define the mechanisms regulating the establishment, development, and maintenance of immunity throughout childhood.
NIH: HEAL Initiative: Integrative Management of chronic Pain and OUD for Whole Recovery (IMPOWR): Research Centers (RM1 Clinical Trial Required) Friday, January 15, 2021 - This FOA seeks research center applications to develop approaches, models, delivery, and implementation of care for co-occurring chronic non-cancer pain and OUD/misuse, which will be supported by a single Coordination and Dissemination Center.
Center for Advancement and Synthesis of Open Environmental Data and Sciences Friday, January 8, 2021 - NSF seeks to establish a Center fueled by open and freely available biological and other environmental data to catalyze novel scientific questions in environmental biology.
NSF: Future of Work at the Human-Technology Frontier: Core Research Friday, January 8, 2021 - This program supports multi-disciplinary or convergent research that addresses technological, human, and societal dimensions of future work.
NIH: NIDA Translational Avant-Garde Award for Development of Medication to Treat Substance Use Disorders (UG3/UH3 Clinical Trial Optional) Friday, January 8, 2021 - The purpose of this award is to support researchers with the vision and expertise to translate research discoveries into medications for the treatment of substance use disorders stemming from tobacco, cannabis, cocaine, methamphetamine, heroin, or prescription opiate use.
ED: FY21 OSERS: OSEP: Educational Technology, Media, and Materials for Individuals with Disabilities Program: Stepping-up Technology Implementation Assistance Friday, January 8, 2021 - The purposes of the Educational Technology, Media, and Materials for Individuals with Disabilities Program are to improve results for children with disabilities.
DoD: Breast Cancer, Transformative Breast Cancer Consortium Award Friday, January 8, 2021 - This program supports collaborations and ideas that will transform the lives of individuals with, and/or at risk for, breast cancer and will significantly accelerate progress toward ending breast cancer.
DOE: FY21 Bioenergy Technologies Office (BETO) Feedstock Technologies and Algae FOA Friday, December 18, 2020 - This FOA will support BETO’s highest priority research and development areas in two BETO programs: Feedstock Technologies and Advanced Algal Systems.
NSF: Dimensions of Biodiversity Friday, December 18, 2020 - This campaign promotes novel integrative approaches to fill the most substantial gaps in our understanding of the diversity of life on Earth.
DOE: Vehicle Technologies Office Fiscal Year 2021 Research Funding Opportunity Announcement Friday, December 18, 2020 - This program seeks research projects to address priorities in the following areas: batteries and electrification; materials; technology integration and energy efficient mobility systems; energy-efficient commercial off-road vehicle technologies; and co-optimized advanced engine and fuel technologies to improve fuel economy.
DoC: Proposed Cooperative Institute to support NOAA Marine Research and Ecosystem Management Friday, December 18, 2020 - The Institute will provide capabilities and collaborations to develop and apply new tools and approaches for monitoring ecosystem health and forecasting ecosystem change and human responses to change.
NSF: Mid-scale Research Infrastructure-2 (Mid-scale RI-2) Monday, December 7, 2020 - This program supports the implementation of unique and compelling research infrastructure projects.
ED: Institute of Education Sciences (IES): Education Research: Transformative Research in The Education Sciences Assistance Listing Number 84.305T Friday, December 4, 2020 - This program supports innovative or unconventional research that has the potential to lead to new scientific paradigms, new and more effective approaches to education practice or policy, or transformative technologies that substantially increase learner outcomes.
NIH:NHLBI Program Project Applications (P01 Clinical Trials Optional) Friday, December 4, 2020 - NHLBI Program Project Grant (P01) supports research related to fundamental processes and diseases of the heart, blood and lymphatic vessels, lungs, and blood.
DoD: Department of Army Ultra-wide Bandgap RF Electronics Center Fiscal Year 2022 Friday, December 4, 2020 - This funding opportunity solicits proposals to establish a multidisciplinary research center for extreme-radio-frequency electronics (x-RF electronics) based on ultra-wide bandgap (UWBG) semiconductors and related emerging materials.
NIH: Analytical Validation of a Candidate Biomarker for Neurological or Neuromuscular Disorders (U01 Clinical Trial Optional) Friday, November 20, 2020 - The purpose of this program is to enable analytical validation of strong candidate biomarkers for neurological diseases and conditions.
USDA: Specialty Crop Research Initiative (SCRI) Pre-Applications Friday, November 20, 2020 - The purpose of the SCRI program is to address the critical needs of the specialty crop industry.
DoD: Department of Army Center for Synthetic Biology Friday, November 20, 2020 - The main objective of this program is to promote discovery and innovation that enable the rapid and effective exploration and validation of novel synthetic biology systems.
(CLOSED) Limited Submission: Advancing Public Health Research in Kenya Thursday, November 19, 2020 - The purpose of this program is to conduct and/or facilitate CDC-initiated epidemiologic studies and surveillance, clinical research, clinical trials, laboratory, and operations research on infectious diseases, non-communicable diseases, and environmental health in Kenya.
Limited Submission: Conducting Research to Inform Pandemic Response and Recovery of Emergency-Affected Populations by Determining Public Health Needs, Improving Methods, and Integrating Services to Mitigate Morbidity and Mortality Friday, November 13, 2020 - The purpose of this NOFO is to understand the needs of emergency-affected and displaced populations and estimate morbidity and mortality in the context of the COVID-19 pandemic.
NIH: Treatments for Lewy Body Dementias–Exploratory Clinical Trial (U01 Clinical Trial Required) Friday, October 30, 2020 - This FOA invites applications from experienced investigators seeking to conduct exploratory clinical trials designed to test new treatments for patients with Lewy Body Dementia (LBD).
NIH: Integrative Neuroscience Initiative on Alcoholism (INIA) Consortia Research Resource (U24) (Clinical Trial Optional) Friday, October 16, 2020 - This FOA solicits Research Resources applications to provide resource and technological support to the administrative resource cores and the individual research projects within each of the two INIA consortia.
DOE: Connected Communities Friday, October 16, 2020 - Under this FOA, DOE will select a portfolio of “Connected Community” projects to find and share technical and market solutions that will increase demand flexibility and energy efficiency.
NIH: New Cohorts for Environmental Exposures and Cancer Risk (CEECR) Coordinating Center (U24 Clinical Trial Not Allowed) Friday, October 16, 2020 - The goal of the CEECR is to support innovative scientific research in new prospective cohorts to address knowledge gaps between environmental exposures and cancer etiology, and the genetic, lifestyle, and behavioral factors that modify risk across diverse populations.
Limited Submission: A Multidisciplinary Approach to Study Vaccine-elicited Immunity and Efficacy against Malaria (U01 Clinical Trial Not Allowed) Friday, October 9, 2020 - The purpose of this initiative is to support research to advance understanding of the underlying immune mechanisms that contribute to malaria vaccine-elicited protection or vaccine hypo-responsiveness in endemic regions.
NIH: Cohort Studies To Improve Our Understanding of Influenza Immunity, Vaccine Response and Effectiveness in Older Adults (65 years and older) (U01 Clinical Trial Not Allowed) Friday, October 2, 2020 - This initiative will support the use of longitudinal cohorts to develop greater understanding of important elements of influenza immunity that impact vaccine response and vaccine effectiveness in older adults.
DOE: FY 2021 Continuation of Solicitation for the Office of Science Financial Assistance Program Friday, October 2, 2020 - The Office of Science of the DOE hereby announces its continuing interest in receiving grant applications for support of work in the following program areas: Advanced Scientific Computing Research, Basic Energy Sciences, Biological and Environmental Research, Fusion Energy Sciences, High Energy Physics, Nuclear Physics, Isotope R&D and Production, and Accelerator R&D and Production.
NIH: Drug Development Collaboratory (UG3/UH3 Clinical Trial Required) Friday, September 25, 2020 - The purpose of this FOA is to support intramural-extramural collaborations on late-stage translational science projects between NCATS Therapeutic Development Branch and extramural researchers, for therapeutic development of small molecules, biologics, or gene therapies.
NIH: Advanced Laboratories for Accelerating the Reach and Impact of Treatments for Youth and Adults with Mental Illness (ALACRITY) Research Centers (P50 Clinical Trial Optional) Friday, September 11, 2020 - Supports the rapid development, testing, and refinement of novel and integrative approaches for (1) optimizing the effectiveness of therapeutic or preventive interventions for mental disorders within well-defined target populations; (2) organizing and delivering optimized mental health services within real world treatment settings; and (3) continuously improving the quality, impact, and durability of optimized interventions and service delivery within diverse care systems.
NIH: HIV Vaccine Research and Design (HIVRAD) Program (P01 Clinical Trial Not Allowed) Friday, September 4, 2020 - The purpose of this FOA is to support multi-component, multi-disciplinary projects that address scientific questions relevant to AIDS prophylactic vaccine discovery research.
Limited Submission: Collaborative Program Grant for Multidisciplinary Teams (RM1 – Clinical Trial Optional) Thursday, August 27, 2020 - This FOA is designed to support highly integrated research teams of 3 to 6 PDs/PIs to address ambitious and challenging research questions that are important for the mission of NIGMS and are beyond the scope of one or two investigators.
NIH: Disseminating and Implementing Patient-Centered Outcomes Research (PCOR) Evidence into Practice through Interoperable Clinical Decision Support Friday, August 21, 2020 - This FOA invites applications that disseminate and implement patient-centered outcomes research evidence into clinical practice through clinical decision support.
NIH: Grand Opportunity in Medications Development for Substance-Use Disorders (U01 – Clinical Trial Optional) Friday, August 14, 2020 - The purpose of this FOA is to accelerate the development of medication for the treatment of Substance Use Disorders (SUDs) by encouraging research applications to support a diverse array of preclinical and/or clinical research projects.
NIH: BRAIN Initiative: Data Archives for the BRAIN Initiative (R24 Clinical Trial Optional) Friday, August 14, 2020 - This FOA solicits applications to develop web-accessible data archives to capture, store, and curate data related to BRAIN Initiative activities.
FY2021 Vannevar Bush Faculty Fellowship Friday, July 10, 2020 - This FOA seeks distinguished researchers for the purpose of conducting innovative basic research in areas of interest to the DoD and fostering long-term relationships between the VBFF Fellows and the DoD.
Tobacco Use and HIV in Low and Middle-Income Countries (U01 Clinical Trial Optional) Friday, July 10, 2020 - This FOA supports the development and evaluation of tobacco cessation interventions tailored to HIV-positive populations, including those with comorbidities such as tuberculosis (TB), in low-resource settings in low- and middle-income countries.
Limited Submission: Continuation of the Human Pancreas Analysis Program (HPAP) for Type 1 Diabetes (HPAP-T1D) (U01 Clinical Trial Not Allowed) Friday, July 10, 2020 - This FOA will support one team of investigators with combined expertise in human pancreas physiology and pathophysiology; collection, processing and multimodal analysis of human pancreatic tissues; and biological database building, curation and management.
Network of the National Library of Medicine Evaluation Center (U24) (Clinical Trial Not Allowed) Monday, July 6, 2020 - The NNLM Evaluation Center (NEC) will coordinate the assessment of the impact, efficacy and value of NNLM activities, services, and resources. A special focus will be placed on assessing community engagement and measuring its impact on persons who experience health disparities, and populations underrepresented in biomedical research.
Technical Assistance and Dissemination to Improve Services and Results for Children with Disabilities and Demonstration and Training Programs Monday, July 6, 2020 - The purpose of the program is to promote academic achievement and to improve results for children with disabilities by providing TA, supporting model demonstration projects, disseminating useful information, and implementing activities that are supported by scientifically based research.
Pediatric Biospecimen Procurement Center (BPC) Supporting the Developmental Gene Expression (dGTEx) Project (U24 Clinical Trial Not Allowed) Monday, July 6, 2020 - The purpose of this funding opportunity is for support of a Biospecimen Procurement Center (BPC) to enroll suitable pediatric donors and provide high quality tissue samples for analyses to the Laboratory, Data Analysis, and Coordinating Center.
Laboratory, Data Analysis, and Coordinating Center (LDACC) for the Developmental Genotype-Tissue Expression Project(U24) (Clinical Trial Not Allowed) Monday, July 6, 2020 - The LDACC will perform 2 major functions: a molecular laboratory to process tissue samples for sequencing and biobanking, and a data analysis and coordinating center to ensure coordination, monitor study progress and laboratory performance, perform basic analysis of data for gene expression analyses, and harmonize and submit datasets to be deposited in repositories such as the AnVIL (Analysis, Visualization, and Informatics Lab-space).
NIH: Hybrid Effectiveness-Implementation Trials for Heart, Lung, Blood, and Sleep Diseases in the Inpatient Setting (U01 – Clinical Trials Required) Friday, June 19, 2020 - This FOA supports hybrid effectiveness-implementation trials for heart, lung, blood, and sleep (HLBS) diseases in the inpatient setting and applications that propose a multidisciplinary research team that includes expertise in inpatient clinical research, implementation research, and biostatistics.
NIH: NIDA Avant-Garde Award Program for HIV/AIDS and Substance Use Disorder Research (DP1, Clinical Trial Optional) Friday, June 5, 2020 - Supports exceptionally creative scientists, who propose high-impact research that will open new areas of HIV/AIDS research in the context of substance use disorders and/or lead to new avenues for prevention and treatment of HIV/AIDS in people who use drugs.
NIH: Regenerative Medicine Innovation Project (RMIP) Investigator-Initiated Clinical Trials (UG3/UH3 Clinical Trial Required) Friday, June 5, 2020 - Seeks meritorious clinical trials proposing to explore and enable the development of safe and effective regenerative medicine interventions using adult stem cells.
DoD Peer Reviewed Alzheimer’s, Accelerating Diagnostics for Traumatic Brain Injury Research Award Friday, May 22, 2020 - Supports high-impact, human-based development of robust diagnostic and/or prognostic biomarkers for chronic TBI as they pertain to AD/ADRD.
NSF: Discovery Research PreK-12 (DRK-12) Wednesday, May 13, 2020 - This program seeks to significantly enhance the learning and teaching of science, technology, engineering, mathematics and computer science by preK-12 students and teachers.