Research Insights
Large Grant Opportunities
The Office of Research hosts a listserv that shares large funding opportunities and internal limited submissions competition announcements weekly, in addition to maintaining a calendar of current limited submissions opportunities. Sign up for the Large Grant Opportunities and Limited Submissions listserv to receive weekly updates.
NFWF: Healthy American Forests Initiative Friday, October 10, 2025 - This funding opportunity will support watershed restoration and vegetation management projects on National Forest System lands to achieve a healthy forest ecosystem. Applicants should develop proposals that increase forest management activities and reduce wildfire risk to ultimately promote healthy forests, increase timber productivity and protect American prosperity. Amount: $250,000 – $2,000,000 Due Date: 01/13/2026 More Information
NSF: Mid-scale Research Infrastructure-1 (Mid-scale RI-1) Friday, October 3, 2025 - This program supports either design or implementation of unique and compelling Research Infrastructure projects. Mid-scale implementation projects may include any combination of equipment, instrumentation, cyberinfrastructure, broadly used large scale datasets and the personnel needed to successfully commission the project. Amount: $400,000 – $20M Due Date: 09/01/2026 (Pre-Proposal); 02/08/2027 (Full Proposal) More Information
NIH: National Institute on Deafness and Other Communication Disorders (NIDCD) Clinical Research Center Grant (P50 Clinical Trial Optional) Friday, September 26, 2025 - The NIDCD invites applications for Clinical Research Center Grants designed to advance the diagnosis, prevention, treatment, and amelioration of human sensory and communication disorders. For this announcement, Clinical Research is defined as research involving individuals with a sensory and/or communication disorder, or data/tissues from individuals with a sensory and/or communication disorder. Amount: $11,325,000 Due Date: 11/04/2025; 02/02/2026 […]
NIH: Rational Design of Vaccines Against Hepatitis C Virus (U19 Clinical Trial Not Allowed) Friday, September 26, 2025 - The purpose of this NOFO is to solicit applications to participate in a consortium of Research Centers focused on designing, optimizing, evaluating, and developing broadly protective vaccines for hepatitis C virus to enable the advancement of vaccine candidates into clinical evaluation. Amount: $15,100,000 Due Date: 11/07/2025 More Information
NIH: Development of Interventions to Prevent and Treat Substance Use Disorders and Overdose (UG3/UH3 – Clinical Trial Optional) Friday, September 26, 2025 - This program supports research on the discovery and development of interventions to prevent and/or treat substance use disorders (SUDs) and overdose, including interventions to treat co-morbid SUDs. This includes preclinical and clinical research studies that will have high impact and quickly yield the necessary results to advance candidate interventions closer to regulatory approval or clinical […]
NEH: Collaborative Research Grants Friday, September 26, 2025 - This program supports groups of two or more scholars seeking to increase humanistic knowledge through convenings, manuscript preparation for collaborative publications, the creation of scholarly digital projects, or the planning of an international collaboration. The work can be rooted in a single field or cross disciplines. NEH encourages projects that incorporate multiple points of view […]
NIH: Nonhuman Primate Reagent Resource (U24 Clinical Trial Not Allowed) Friday, September 12, 2025 - This NOFO aims to support the Nonhuman Primate Reagent Resource (NHPRR) with the goal of ensuring reagent accessibility to the NHP research community. The scope covers two broad categories: 1) development, acquisition, production, and distribution of immunologic reagents; and 2) website, management, and community engagement activities. Amount: Unspecified Due Date: 10/28/2025 More Information
NIH: Influenza Transmission Research Consortium (P01 Clinical Trial Optional) Friday, September 12, 2025 - The objective of this NOFO is to establish the Influenza Transmission Research Consortium: a network of Centers conducting collaborative, multidisciplinary research that will further understanding of the factors driving human-to-human influenza transmission. Applications are sought that propose well-integrated, cross-disciplinary research teams with varied expertise that may include, but is not limited to: virology, host genetics, […]
NIH: Partnerships for Development of Vaccines to Prevent Mycobacterium tuberculosis Infection and/or Disease (R01 Clinical Trial Not Allowed) Friday, August 29, 2025 - This program solicits research applications focused on preclinical development of lead candidate vaccines to prevent Mycobacterium tuberculosis (Mtb) infection and/or disease, and to increase the clinical pipeline of viable vaccine candidates. Amount: $5,662,500 Due Date: 10/07/2025 (LOI); 11/07/2025 (Full Proposal) More Information
NIH: Tuberculosis Research Units (P01 Clinical Trial Optional) Friday, August 29, 2025 - This program supports the establishment of multidisciplinary Tuberculosis (TB) Research Units (TBRUs) that will operate as a collaborative network to improve understanding of Mycobacterium tuberculosis (Mtb)-host interactions through characterizing the roles of bacterial and host heterogeneity on infection outcomes and disease progression, and defining bacterial and host determinants relevant to Mtb establishment, dissemination, and disease […]
NSF: Growing Convergence Research (GCR) Monday, August 25, 2025 - This program supports transitioning teams from research that is multidisciplinary to research that transcends disciplinary boundaries with novel conceptual frameworks, theories and methods. Proposals should explore novel avenues not previously investigated that are at the forefront of advancing science through deep integration. Amount: $1,200,000 (Phase I); $2,400,000 (Phase II) Due Date: 02/09/2026 More Information
The Teagle Foundation: Cornerstone Learning for Living Monday, August 25, 2025 - This initiative aims to reinvigorate the role of the humanities in general education, and in doing so, expose a broad array of students to the power of the humanities; help students of all backgrounds build a sense of belonging and community; strengthen the coherence and cohesiveness of general education; and increase teaching opportunities for humanities […]
FDA: Efficient and Innovative Natural History Studies Addressing Unmet Needs in Rare Diseases Friday, August 1, 2025 - This funding opportunity supports prospective or retrospective, efficient, and innovative natural history studies with a focus on collaborative and standardized approaches to ensure data quality and interpretability. Amount: $1,600,000 (Prospective Studies); $300,000 (Retrospective Studies) Due Date: 01/09/2026 (LOI); 02/10/2026 (Full Proposal) More information
Gateway for Cancer Research: Gateway Traditional Grant Program Wednesday, July 16, 2025 - Gateway funds Phase I and II patient-centered cancer clinical trials that have the potential to shift the paradigm for standard of care. This program funds early phase clinical trials for cancers of all types at institutions around the world. These grants are typically 2-5 years in duration. Amount: Typically$200,000 – $1,500,000 Due Date: 11/05/2025 (LOI) […]
FDA: Clinical Studies of Orphan Products Addressing Unmet Needs of Rare Diseases Wednesday, July 16, 2025 - This funding opportunity supports clinical trials of orphan products in all phases of product development (phase 1, 2 and/or 3) for rare diseases with unmet medical needs. These clinical trials should evaluate safety and/or efficacy of medical products in support of a new indication or a change in labeling. Amount: $2,600,000 Due Date: 09/22/2025 (LOI); […]
Lupus Research Alliance: Global Team Science Award Wednesday, July 9, 2025 - This program supports interdisciplinary, collaborative, and highly synergistic projects that focus on the molecular understanding of human lupus and the heterogeneity of the disease. Successful teams will push the boundaries of innovation and bridge research and clinical efforts in lupus by using cutting-edge technologies to address critical questions that could bring about breakthroughs in lupus […]
The Hairy Cell Leukemia Foundation-Leukemia & Lymphoma Society: HCL2030 Collaborative Team Grants Wednesday, July 9, 2025 - This program funds targeted research to uncover novel features of classic Hairy Cell Leukemia (HCL) biology, understand the distinguishing features of HCL variant and apply that knowledge in the clinic, translate new medical knowledge to clinical application, test novel treatments in patients through clinical trials, and apply the HCL registry created by HCLF to examine […]
NEH: Scholarly Editions and Translations Friday, June 27, 2025 - This program supports collaborative teams who are editing, annotating, and translating foundational humanities texts that are vital to generating new scholarships but are inaccessible or only available in inadequate editions or translations. Works from any humanities field may be the subject of an edition. Amount: $65,000 (Planning); $300,000 (Implementation) Due Date: 09/29/2025 (Optional Draft); 12/03/2025 […]
Simons Foundation: Simons Collaborations in Mathematics and the Physical Sciences Friday, June 27, 2025 - This program aims to stimulate progress on fundamental scientific questions of major importance in mathematics, theoretical physics and theoretical computer science. Proposals should address a mathematical or theoretical topic of fundamental scientific importance, where a significant, new development creates a novel area for exploration or provides a new direction for progress in an established field. […]
NSF: Computer Science for All Friday, June 6, 2025 - This program supports partnerships and research that helps equip high school teachers to teach computer science, K-8 teachers to incorporate computer science and computational thinking in their classes, and school districts to create computing pathways across all grades. Amount: $300,000 (Small RPP); $1,000,000 (Medium RPP); $2,000,000 (Large RPP) Due Date: 02/11/2026 More information
NSF: Growing Convergence Research (GCR) Friday, June 6, 2025 - This program aims to cultivate and grow the earliest foundations of convergent approaches for addressing a specific and compelling problem. Proposals should explore novel avenues not previously investigated that are at the forefront of advancing science through deep integration. Amount: $1,200,000 (Phase I); $2,400,000 (Phase II) Due Date: 02/09/2026
NHPRC: Archival Projects Wednesday, May 14, 2025 - This program supports archival projects that will significantly improve online public discovery and use of historical records collections. The program welcomes projects that engage the public, expand civic education, and promote understanding of the nation’s history, democracy, and culture from the founding era to the present day. Amount: $150,000 Due Date: 08/15/2025 (Optional Draft); 11/05/2025 […]
NSF: Expeditions in Computing (Expeditions) Thursday, May 8, 2025 - NSF: Expeditions in Computing (Expeditions) This program provides the Computer and Information Science and Engineering (CISE) research and education community with the opportunity to pursue ambitious, fundamental research agendas that promise to define the future of computing and information. Amount: $15,000,000 Due Date: 06/22/2026 (Pre-Proposals) More Information
NSF: Cyberinfrastructure for Sustained Scientific Innovation (CSSI) Wednesday, April 30, 2025 - This program seeks to enable funding opportunities that are flexible and responsive to the evolving and emerging needs in cyberinfrastructure (CI). The program continues to emphasize integrated CI services, quantitative metrics with targets for delivery and usage of these services, and community creation. Amount: $600,000 (Elements); $1,000,000 (Transition to Sustainability); $600,001-$5,000,000 (Framework Implementations) Due Date: 12/01/2025 More Information
NSF: Archaeology Program Senior Research Awards (Arch-SR) Friday, April 25, 2025 - This program supports anthropologically relevant archaeological research to increase understanding of past behaviors. Amount: $200,000 – $350,000 Due Date: 12/01/2025 More Information
NSF: Growing Convergence Research (GCR) Friday, February 21, 2025 - This program aims to cultivate and grow the earliest foundations of convergent approaches for addressing a specific and compelling problem. Proposals should explore novel avenues not previously investigated that are at the forefront of advancing science through deep integration. Amount: $1,200,000 (Phase I); $2,400,000 (Phase II) Due Date: 02/09/2026 More Information
Georgia Network for Electric Mobility Seed Grants Tuesday, November 26, 2024 - This program supports interdisciplinary research in e-mobility related topics along the electric vehicle/mobility value chain such as battery manufacturing and rare earth materials mining, supply chain and logistics, vehicle manufacturing, charging infrastructure and utilities, sales and consumer knowledge, and battery and EV components/materials recycling. Amount: $40,000 up to $60,000 per award Proposal due date: December 18, […]
NEH: Landmarks of American History and Culture Wednesday, November 13, 2024 - This program supports a series of one-week residential, virtual, and combined format workshops across the nation to enhance how K-12 educators and higher education faculty and humanities professionals incorporate place-based approaches to humanities teaching and scholarship. Amount: $190,000 Due Date: 01/06/2025 (Optional Draft); 12/12/2025 (Full Proposal) More Information
NIH: Building Interdisciplinary Research Careers in Women’s Health (BIRCWH) (K12 Clinical Trial Optional) Monday, March 18, 2024 - This program supports mentored research career development of junior faculty members who have recently completed clinical training or postdoctoral fellowships, and who will be engaged in interdisciplinary basic, translational, data science, behavioral, clinical, and/or health services research relevant to the health of women and, where appropriate, the use of both sexes to better understand the […]
NIH: Individually Measured Phenotypes to Advance Computational Translation in Mental Health Wednesday, May 10, 2023 - Supports the work of the research projects funded under the Individually Measured Phenotypes to Advance Computational Translation in Mental Health (IMPACT-MH) initiative described in the companion announcement RFA-MH-23-105. Amount: $18,875,000 Due Date: 6/14/23 More Information
NEH: Digital Projects for the Public Wednesday, March 22, 2023 - This program supports projects that interpret and analyze humanities content in primarily digital platforms and formats, such as websites, mobile applications and tours, interactive touch screens and kiosks, games, and virtual environments. Amount: $400,000 Due Date: 6/14/23 More Information
NIH: Development of Novel Nonsteroidal Contraceptive Methods Tuesday, October 18, 2022 - Supports multidisciplinary research approaches for the development of novel nonsteroidal contraceptive products for men and women that act prior to fertilization. Amount: $3,020,000 Due Date: 3/29/23 More information
NIH: BRAIN Initiative: Exploratory Team-Research BRAIN Circuit Programs Wednesday, March 16, 2022 - Supports interdisciplinary teams to elucidate the contributions of dynamic circuit activity to a specific behavioral or neural system.
NSF: Biodiversity on a Changing Planet (BoCP) Thursday, October 21, 2021 - The Biodiversity on a Changing Planet program is a cross directorate and international program led by NSF that invites submission of interdisciplinary proposals addressing grand challenges in biodiversity science within the context of unprecedented environmental change.
CDC: Vector-Borne Disease Regional Centers of Excellence Thursday, October 21, 2021 - The purpose of this NOFO is to support research to improve national capacity to address the growing problem of vector-borne diseases via continued support for regional Centers of Excellence for Vector-Borne Diseases.
NSF: Harnessing the Data Revolution (HDR): Transdisciplinary Research in Principles of Data Science Phase II (TRIPODS) Monday, October 18, 2021 - NSF's Harnessing the Data Revolution Big Idea is a national-scale activity to enable new modes of data-driven discovery that will allow fundamental questions to be asked and answered at the frontiers of science and engineering.
NSF: Computer and Information Science and Engineering (CISE) Community Research Infrastructure Program Monday, October 18, 2021 - The Computer and Information Science and Engineering Community Research Infrastructure program drives discovery and learning in the core CISE disciplines by funding the creation and enhancement of world-class research infrastructure.
NIH: Development of Microbiome-Related Approaches for Diagnosis/Mitigation/Treatment of Radiation Injuries (U01 Clinical Trial Not Allowed) Monday, October 11, 2021 - The purpose of this FOA is to support research that will advance the understanding of how the microbiome affects radiation injury.
DOC: US Marine Life Observations: Coordinated Marine Biodiversity Observation Network (MBON) and Animal Telemetry Network (ATN) Activities to Ensure Resilient, Productive Ecosystems and Human Communities in the Face of Change Monday, October 11, 2021 - This program supports proposals that: (1) build upon the foundation established by MBON, ATN and the US IOOS Regional Associations to work across sectors and disciplines towards an integrated, sustained marine life observing capability for the U.S. ocean, coasts and Great Lakes, from estuaries to the deep ocean.
NIH: Systems Biology for Infectious Diseases (U19 Clinical Trial Not Allowed) Monday, October 11, 2021 - The purpose of the FOA is to support research that employs systems biology approaches to human pathogens.
NIH: SPARC Human Open Research Neural Engineering Technologies (HORNET) Initiative (U41) Monday, October 11, 2021 - This U41 opportunity will fund centers to create interoperable open-source modules that can be combined into custom profiles for new exploratory and clinical neuromodulation studies in the peripheral nervous system, and for potential applicability in the central nervous system.
NIH: Pediatric Obesity Discovery Science Research to Improve Understanding of Risk and Causal Mechanisms for Obesity in Early Life (R01) Monday, October 11, 2021 - The purpose of this FOA is to support innovative, discovery research studies to better characterize early-life risk factors and elucidate underlying causal mechanisms through which these risk factors contribute to the development of obesity during infancy and early childhood.
NSF: Integrative Research in Biology (IntBIO) Saturday, September 25, 2021 - This solicitation invites submission of collaborative proposals that tackle bold questions in biology and require an integrated approach to make substantive progress.
NSF: Cyberinfrastructure for Sustained Scientific Innovation (CSSI) Saturday, September 25, 2021 - This solicitation expands the Cyberinfrastructure for Sustained Scientific Innovation program by adding a new project class: Transition to Sustainability.
NSF: Biology Integration Institutes (BII) Tuesday, September 21, 2021 - The NSF Directorate for Biological Sciences program for Biology Integration Institutes (BII) supports diverse and collaborative teams of researchers investigating questions that span multiple disciplines within and beyond biology.
NSF: EHR Core Research – Resource Coordination Hub (ECR Hub) Monday, September 13, 2021 - NSF seeks proposals to create an EHR Core Research (ECR) Resource Coordination Hub (ECR Hub) that will be an intellectual partner to the ECR:Core and the ECR:BCSER grantee communities and the NSF to enhance the overall influence and reach of ECR STEM education research investments.
DOE: Natural Gas Demand Response Pilot Program Monday, September 13, 2021 - FOA soliciting cooperative agreements for the development of multiple regional natural gas demand response pilot programs in collaboration with utilities, local distribution companies and public utility commissions.
NEH: Digital Humanities Advancement Grants Monday, September 13, 2021 - computationally challenging digital projects, leading to work that can scale to enhance scholarly research, teaching and public programming in the humanities.
NSF: Facility and Instrumentation Request Process (FIRP) Monday, September 13, 2021 - The Facility and Instrumentation Request Process (FIRP) solicitation describes the mechanism by which the research community can propose projects that require access to instrumentation and facilities sponsored by the FARE Program.
NIH: National Cancer Institute Youth Enjoy Science Research Education Program (R25) Friday, September 3, 2021 - This funding opportunity seeks to facilitate the education of students from diverse backgrounds underrepresented in biomedical research who will become knowledgeable about cancer, and available to focus on cancer later in their careers.
NSF: Mathematical Sciences Research Institutes Tuesday, July 6, 2021 - The goals of the Mathematical Sciences Research Institutes program include advancing research in the mathematical sciences, increasing the impact of the mathematical sciences in other disciplines, and expanding the talent base engaged in mathematical research in the United States.
FY2021 Vannevar Bush Faculty Fellowship Friday, July 10, 2020 - This FOA seeks distinguished researchers for the purpose of conducting innovative basic research in areas of interest to the DoD and fostering long-term relationships between the VBFF Fellows and the DoD.
Tobacco Use and HIV in Low and Middle-Income Countries (U01 Clinical Trial Optional) Friday, July 10, 2020 - This FOA supports the development and evaluation of tobacco cessation interventions tailored to HIV-positive populations, including those with comorbidities such as tuberculosis (TB), in low-resource settings in low- and middle-income countries.
Limited Submission: Continuation of the Human Pancreas Analysis Program (HPAP) for Type 1 Diabetes (HPAP-T1D) (U01 Clinical Trial Not Allowed) Friday, July 10, 2020 - This FOA will support one team of investigators with combined expertise in human pancreas physiology and pathophysiology; collection, processing and multimodal analysis of human pancreatic tissues; and biological database building, curation and management.
Network of the National Library of Medicine Evaluation Center (U24) (Clinical Trial Not Allowed) Monday, July 6, 2020 - The NNLM Evaluation Center (NEC) will coordinate the assessment of the impact, efficacy and value of NNLM activities, services, and resources. A special focus will be placed on assessing community engagement and measuring its impact on persons who experience health disparities, and populations underrepresented in biomedical research.