Research Insights
Large Grant Opportunities
Sign up for the large grant opportunities and limited submissions listserv. The Office of Research hosts a listserv that shares large funding opportunities and internal competition announcements weekly as well as a calendar of current limited submissions opportunities.
NSF: Growing Convergence Research (GCR) Wednesday, November 20, 2024 - This program aims to cultivate and grow the earliest foundations of convergent approaches for addressing a specific and compelling problem. Proposals should explore novel avenues not previously investigated that are at the forefront of advancing science through deep integration. Amount: $1,200,000 (Phase I); $2,400,000 (Phase II) Due Date: 02/10/2025 More Information
NIH: Combating Antibiotic-Resistant Bacteria Interdisciplinary Research Units (CARBIRUs) (P01 Clinical Trial Not Allowed) Wednesday, November 13, 2024 - This program supports multidisciplinary research programs focused on discovery to early development research to inform new approaches to prevent, diagnose, and treat antibiotic-resistant bacterial infections. Amount: $11,325,000 Due Date: 02/24/2025 (LOI); 03/26/2025 (Full Proposal) More Information
NEH: Landmarks of American History and Culture Wednesday, November 13, 2024 - This program supports a series of one-week residential, virtual, and combined format workshops across the nation to enhance how K-12 educators and higher education faculty and humanities professionals incorporate place-based approaches to humanities teaching and scholarship. Amount: $190,000 Due Date: 01/06/2025 (Optional Draft); 12/12/2025 (Full Proposal) More Information
NIH: Centers for Accelerating Phage (Bacteriophage) Therapy to Combat ESKAPE Pathogens (CAPT-CEP) (P01 Clinical Trial Not Allowed) Friday, October 25, 2024 - This program aims to establish Centers for Accelerating Phage Therapy to combat ESKAPE pathogens. These Centers will develop preclinical assays, tools, and models and conduct essential studies that facilitate robust phage therapeutics against ESKAPE pathogens, contributing significantly to the fight against antibiotic resistance. Amount: $9,060,000 Due Date: 12/27/2024 (LOI); 01/28/2025 (Full Proposal) More Information
NIH: Human Brain Single-cell Genomics Explorer (U24 – Clinical Trial Not Allowed) Friday, October 18, 2024 - This program is soliciting applications to pilot the establishment of an integrated resource for users to explore, analyze, and download processed deidentified human brain single-cell transcriptomics and epigenomics data that is harmonized across reference and disease datasets. Amount: $4,530,000 Due Date: 01/14/2025 (LOI); 02/14/2025 (Full Proposal) More Information
NSF: Addressing Systems Challenges through Engineering Teams Friday, October 18, 2024 - This program offers the opportunity to address research issues and answer engineering challenges associated with complex systems and networks that are not achievable by a single principal investigator or by short-term projects and can only be achieved by interdisciplinary research teams. Amount: $1,000,000 – $1,500,000 Due Date: 01/22/2025 More Information
DOE: Genomics – Enabled Understanding and Advancing Knowledge on Plant Gene Function(s) Friday, October 18, 2024 - The overarching goal of this program is to address the challenges and opportunities in associating gene(s) to function, as well as to understand the biological processes relevant for plant transformation in plant systems of relevance to the Biological and Environmental Research mission. Amount: $750,000 – $3,000,000 Due Date: 12/02/2024 (Pre-Applications); 02/10/2025 (Full Proposals) More Information
DOD: FY25 Minerva Research Initiative University Research Program Friday, October 18, 2024 - This program supports innovative basic research projects that contribute to the advancement of social science and provides new methods and understandings on social and behavioral questions of security and defense-related interest. Amount: up to $5,000,000 Due Date: 11/29/2024 (White Papers); 02/28/2025 (Full Proposals) More Information
NIH: Centers for Precision Disease Modeling (U54) (Clinical Trials Not Allowed) Friday, October 11, 2024 - The goal of the Centers is to support collaborative research projects that bridge current personalized medicine efforts in human subjects with advances in animal genomics and genetic manipulation technologies, including the creation of interspecies somatic hybrids. Amount: $9,437,500 Due Date: 12/15/2024 More Information
NEH: Sustaining Cultural Heritage Collections Friday, October 11, 2024 - This program helps cultural institutions meet the complex challenge of preserving large and diverse holdings of humanities materials for future generations by supporting environmentally sustainable preventive care measures. Amount: $50,000 – $350,000 Due Date: 12/05/2024 (Optional Draft); 01/10/2025 (Full Proposal) More Information
DOE: Gasification of Alternative Feedstocks Friday, October 4, 2024 - This program supports development of innovative gasification designs/systems for converting alternative feedstocks into syngas to enable the low-cost production of clean hydrogen. Amount: $3,000,000 Due Date: 11/22/2024 More Information
NSF: Computer and Information Science and Engineering (CISE): Core Programs, Large Projects Wednesday, September 18, 2024 - This solicitation invites proposals on bold new scientific ideas tackling ambitious fundamental research problems that cross the boundaries of two or more CISE core programs, which range from Computing and Communications to Computer and Network Systems, to Information and Intelligence Systems. Amount: $3,000,000 – $5,000,000 Due Date: 09/29/2025 More Information
NSF: Discovery Research PreK-12 Program Resource Center on Transformative Education Research and Translation (DRK-12 RC) Friday, September 13, 2024 - This Center will be an intellectual partner as NSF seeks to enhance the overall influence and reach of the DRK-12 Program’s research and development investments. The DRK-12 RC will support and recruit diverse, multi-sector constituencies with the goal of achieving the field-, knowledge-, and partnership-building aims of the DRK-12 program. Amount: $5,000,000 Due Date: 02/28/2025 More Information
NEH: Digital Humanities Advancement Grants Friday, September 13, 2024 - This program supports work that is innovative, experimental, and contributes to the critical infrastructure that underpins scholarly research, teaching, and public programming in the humanities. Amount: Up to $350,000 Due Date: 01/09/2025 More Information
NSF Trailblazer Engineering Impact Award Wednesday, September 4, 2024 - This program supports individual investigators who propose novel research projects with the potential to innovatively and creatively address national needs and/or grand challenges, advance US leadership, and catalyze the convergence of engineering and science domains. Amount: $3,000,000 Due Date: 11/15/2024 (LOI); 01/14/2025 (Pre-Proposal) More Information
NSF: Mid-scale Research Infrastructure-1 (Mid-scale RI-1) Wednesday, August 28, 2024 - This program supports either design or implementation of unique and compelling Research Infrastructure projects. Mid-scale implementation projects may include any combination of equipment, instrumentation, cyberinfrastructure, broadly used large scale datasets and the personnel needed to successfully commission the project. Amount: $400,000 – $20M Due Date: 11/18/2024 (Pre-Proposal); 03/19/2025 (Invited Full Proposals) More Information
NSF: Regional Resilience Innovation Incubator Wednesday, August 21, 2024 - This program supports community-engaged team science to co-design high-impact solutions to climate-related societal challenges that leverage recent advances in fundamental climate change and Earth system science research. Amount: $500,000 (Phase 1); $15,000,000 (Phase 2) Due Date: 12/16/2024 (LOI); 01/16/2025 (Full Proposal) More Information
NIH: Translating Socioenvironmental Influences on Neurocognitive Development and Addiction Risk (TranSINDA) (U24 Clinical Trial Not Allowed) Wednesday, July 24, 2024 - This program invites applications for a Data Coordination Center (DCC) to serve as the organizational hub for the management and sharing of TranSINDA data, establish a modern data ecosystem that integrates TranSINDA data into appropriate data repositories under common data standards and serves as a resource for software tools for large scale data query, analysis, […]
NIH: Halting Tuberculosis (TB) Transmission (R01 Clinical Trial Optional) Wednesday, July 24, 2024 - This program aims to understand the critical drivers of tuberculosis (TB) transmission; develop effective methods to measure rates of TB transmission; and assess potential interventions to prevent TB transmission and detect infectious TB. Amount: $5,662,500 Due Date: 11/04/2024 (LOI); 12/04/2024 (Full Proposal) More information
NSF: Cyberinfrastructure for Sustained Scientific Innovation (CSSI) Friday, July 19, 2024 - This program enables science and engineering research and education by developing, creating, and supporting secure, advanced, scalable, and global research cyberinfrastructure (CI). The program emphasizes integrated CI services, quantitative metrics with targets for delivery and usage of these services, and community creation, and encourages broad, interdisciplinary proposals. Amount: $600,000 (Elements); $600,001 – $5,000,000 (Framework Implementations) […]
NIH: Alzheimer’s Drug-Development Program (U01 Clinical Trial Optional) Thursday, June 27, 2024 - This program invites applications proposing pre-clinical and early stage clinical (Phase I) development of novel small-molecule and biologic drug candidates that aim to prevent Alzheimer’s disease (AD), slow its progression, or treat its cognitive and behavioral symptoms. Amount: $11,325,000 Due Date: 02/05/2025 More information
NSF: Accelerating Computing-Enabled Scientific Discovery (ACED) – Discovery Proposals Wednesday, June 12, 2024 - This program seeks to harness computing to accelerate scientific discovery, while driving new computing advancements. Amount: $3,000,000 Due Date: 01/14/2025 More information
Alzheimer’s Drug Discovery Foundation: Prevention RFP Tuesday, May 21, 2024 - This program supports studies of cognitive symptoms due to health conditions, comparative effectiveness research, and epidemiological studies that probe whether the use or choice of drugs alters the risk for dementia or cognitive decline. Amount: $5,000,000 Due Date: 09/30/2024 (LOI); 12/09/2024 (Full Proposal) More information
Alzheimer’s Drug Discovery Foundation: Drug Development RFP Tuesday, May 21, 2024 - This program supports investigational new drug-enabling studies and early-phase clinical trials that test promising pharmacological interventions and devices for Alzheimer’s disease and related dementias. Amount: $5,000,000 Due Date: 09/30/2024 (LOI); 12/09/2024 (Full Proposal) More information
NSF: Molecular Foundations for Sustainability: Sustainable Polymers Enabled by Emerging Data Analytics (MFS-SPEED) Tuesday, May 21, 2024 - This program’s goal is to support fundamental research enabling the accelerated discovery and ultimate manufacturing of sustainable polymers using state-of-the-art data science, and to enhance development of a cross-disciplinary workforce skilled in this area. Amount: $2,000,000 Due Date: 01/16/2025 More information
NIH: Building Interdisciplinary Research Careers in Women’s Health (BIRCWH) (K12 Clinical Trial Optional) Monday, March 18, 2024 - This program supports mentored research career development of junior faculty members who have recently completed clinical training or postdoctoral fellowships, and who will be engaged in interdisciplinary basic, translational, data science, behavioral, clinical, and/or health services research relevant to the health of women and, where appropriate, the use of both sexes to better understand the […]
NIH: Centers of Excellence for Translational Research (CETR) (U19 Clinical Trial Not Allowed) Wednesday, December 20, 2023 - This program will support multidisciplinary translational research Centers focused on generating, validating, and advancing medical countermeasures against bacteria or fungi listed in the NOFO with known and emerging resistance to current therapies. Amount: $37,750,000 Due Date: 03/29/2024 (LOI);04/30/2024 (Full Proposal) More information
NIH: Individually Measured Phenotypes to Advance Computational Translation in Mental Health Wednesday, May 10, 2023 - Supports the work of the research projects funded under the Individually Measured Phenotypes to Advance Computational Translation in Mental Health (IMPACT-MH) initiative described in the companion announcement RFA-MH-23-105. Amount: $18,875,000 Due Date: 6/14/23 More Information
NEH: Digital Projects for the Public Wednesday, March 22, 2023 - This program supports projects that interpret and analyze humanities content in primarily digital platforms and formats, such as websites, mobile applications and tours, interactive touch screens and kiosks, games, and virtual environments. Amount: $400,000 Due Date: 6/14/23 More Information
NIH: Development of Novel Nonsteroidal Contraceptive Methods Tuesday, October 18, 2022 - Supports multidisciplinary research approaches for the development of novel nonsteroidal contraceptive products for men and women that act prior to fertilization. Amount: $3,020,000 Due Date: 3/29/23 More information
NIH: BRAIN Initiative: Exploratory Team-Research BRAIN Circuit Programs Wednesday, March 16, 2022 - Supports interdisciplinary teams to elucidate the contributions of dynamic circuit activity to a specific behavioral or neural system.
NSF: Biodiversity on a Changing Planet (BoCP) Thursday, October 21, 2021 - The Biodiversity on a Changing Planet program is a cross directorate and international program led by NSF that invites submission of interdisciplinary proposals addressing grand challenges in biodiversity science within the context of unprecedented environmental change.
CDC: Vector-Borne Disease Regional Centers of Excellence Thursday, October 21, 2021 - The purpose of this NOFO is to support research to improve national capacity to address the growing problem of vector-borne diseases via continued support for regional Centers of Excellence for Vector-Borne Diseases.
NSF: Harnessing the Data Revolution (HDR): Transdisciplinary Research in Principles of Data Science Phase II (TRIPODS) Monday, October 18, 2021 - NSF's Harnessing the Data Revolution Big Idea is a national-scale activity to enable new modes of data-driven discovery that will allow fundamental questions to be asked and answered at the frontiers of science and engineering.
NSF: Computer and Information Science and Engineering (CISE) Community Research Infrastructure Program Monday, October 18, 2021 - The Computer and Information Science and Engineering Community Research Infrastructure program drives discovery and learning in the core CISE disciplines by funding the creation and enhancement of world-class research infrastructure.
NIH: Development of Microbiome-Related Approaches for Diagnosis/Mitigation/Treatment of Radiation Injuries (U01 Clinical Trial Not Allowed) Monday, October 11, 2021 - The purpose of this FOA is to support research that will advance the understanding of how the microbiome affects radiation injury.
DOC: US Marine Life Observations: Coordinated Marine Biodiversity Observation Network (MBON) and Animal Telemetry Network (ATN) Activities to Ensure Resilient, Productive Ecosystems and Human Communities in the Face of Change Monday, October 11, 2021 - This program supports proposals that: (1) build upon the foundation established by MBON, ATN and the US IOOS Regional Associations to work across sectors and disciplines towards an integrated, sustained marine life observing capability for the U.S. ocean, coasts and Great Lakes, from estuaries to the deep ocean.
NIH: Systems Biology for Infectious Diseases (U19 Clinical Trial Not Allowed) Monday, October 11, 2021 - The purpose of the FOA is to support research that employs systems biology approaches to human pathogens.
NIH: SPARC Human Open Research Neural Engineering Technologies (HORNET) Initiative (U41) Monday, October 11, 2021 - This U41 opportunity will fund centers to create interoperable open-source modules that can be combined into custom profiles for new exploratory and clinical neuromodulation studies in the peripheral nervous system, and for potential applicability in the central nervous system.
NIH: Pediatric Obesity Discovery Science Research to Improve Understanding of Risk and Causal Mechanisms for Obesity in Early Life (R01) Monday, October 11, 2021 - The purpose of this FOA is to support innovative, discovery research studies to better characterize early-life risk factors and elucidate underlying causal mechanisms through which these risk factors contribute to the development of obesity during infancy and early childhood.
NSF: Integrative Research in Biology (IntBIO) Saturday, September 25, 2021 - This solicitation invites submission of collaborative proposals that tackle bold questions in biology and require an integrated approach to make substantive progress.
NSF: Cyberinfrastructure for Sustained Scientific Innovation (CSSI) Saturday, September 25, 2021 - This solicitation expands the Cyberinfrastructure for Sustained Scientific Innovation program by adding a new project class: Transition to Sustainability.
NSF: Biology Integration Institutes (BII) Tuesday, September 21, 2021 - The NSF Directorate for Biological Sciences program for Biology Integration Institutes (BII) supports diverse and collaborative teams of researchers investigating questions that span multiple disciplines within and beyond biology.
NSF: EHR Core Research – Resource Coordination Hub (ECR Hub) Monday, September 13, 2021 - NSF seeks proposals to create an EHR Core Research (ECR) Resource Coordination Hub (ECR Hub) that will be an intellectual partner to the ECR:Core and the ECR:BCSER grantee communities and the NSF to enhance the overall influence and reach of ECR STEM education research investments.
DOE: Natural Gas Demand Response Pilot Program Monday, September 13, 2021 - FOA soliciting cooperative agreements for the development of multiple regional natural gas demand response pilot programs in collaboration with utilities, local distribution companies and public utility commissions.
NEH: Digital Humanities Advancement Grants Monday, September 13, 2021 - computationally challenging digital projects, leading to work that can scale to enhance scholarly research, teaching and public programming in the humanities.
NSF: Facility and Instrumentation Request Process (FIRP) Monday, September 13, 2021 - The Facility and Instrumentation Request Process (FIRP) solicitation describes the mechanism by which the research community can propose projects that require access to instrumentation and facilities sponsored by the FARE Program.
NIH: National Cancer Institute Youth Enjoy Science Research Education Program (R25) Friday, September 3, 2021 - This funding opportunity seeks to facilitate the education of students from diverse backgrounds underrepresented in biomedical research who will become knowledgeable about cancer, and available to focus on cancer later in their careers.
NSF: Mathematical Sciences Research Institutes Tuesday, July 6, 2021 - The goals of the Mathematical Sciences Research Institutes program include advancing research in the mathematical sciences, increasing the impact of the mathematical sciences in other disciplines, and expanding the talent base engaged in mathematical research in the United States.
FY2021 Vannevar Bush Faculty Fellowship Friday, July 10, 2020 - This FOA seeks distinguished researchers for the purpose of conducting innovative basic research in areas of interest to the DoD and fostering long-term relationships between the VBFF Fellows and the DoD.
Tobacco Use and HIV in Low and Middle-Income Countries (U01 Clinical Trial Optional) Friday, July 10, 2020 - This FOA supports the development and evaluation of tobacco cessation interventions tailored to HIV-positive populations, including those with comorbidities such as tuberculosis (TB), in low-resource settings in low- and middle-income countries.
Limited Submission: Continuation of the Human Pancreas Analysis Program (HPAP) for Type 1 Diabetes (HPAP-T1D) (U01 Clinical Trial Not Allowed) Friday, July 10, 2020 - This FOA will support one team of investigators with combined expertise in human pancreas physiology and pathophysiology; collection, processing and multimodal analysis of human pancreatic tissues; and biological database building, curation and management.
Network of the National Library of Medicine Evaluation Center (U24) (Clinical Trial Not Allowed) Monday, July 6, 2020 - The NNLM Evaluation Center (NEC) will coordinate the assessment of the impact, efficacy and value of NNLM activities, services, and resources. A special focus will be placed on assessing community engagement and measuring its impact on persons who experience health disparities, and populations underrepresented in biomedical research.
Technical Assistance and Dissemination to Improve Services and Results for Children with Disabilities and Demonstration and Training Programs Monday, July 6, 2020 - The purpose of the program is to promote academic achievement and to improve results for children with disabilities by providing TA, supporting model demonstration projects, disseminating useful information, and implementing activities that are supported by scientifically based research.
Pediatric Biospecimen Procurement Center (BPC) Supporting the Developmental Gene Expression (dGTEx) Project (U24 Clinical Trial Not Allowed) Monday, July 6, 2020 - The purpose of this funding opportunity is for support of a Biospecimen Procurement Center (BPC) to enroll suitable pediatric donors and provide high quality tissue samples for analyses to the Laboratory, Data Analysis, and Coordinating Center.