{"id":1603,"date":"2024-09-24T15:59:46","date_gmt":"2024-09-24T15:59:46","guid":{"rendered":"https:\/\/research.uga.edu\/team-research\/?post_type=projects&p=1603"},"modified":"2024-09-24T15:59:46","modified_gmt":"2024-09-24T15:59:46","slug":"novel-inhibitors-targeting-malaria-transmission-in-diverse-plasmodium-species","status":"publish","type":"projects","link":"https:\/\/research.uga.edu\/team-research\/projects\/novel-inhibitors-targeting-malaria-transmission-in-diverse-plasmodium-species\/","title":{"rendered":"Novel inhibitors targeting malaria transmission in diverse Plasmodium species"},"content":{"rendered":"

[vc_row css=”.vc_custom_1727193564356{margin-top: 0px !important;margin-right: 0px !important;margin-bottom: 0px !important;margin-left: 0px !important;padding-top: 0px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 0px !important;}”][vc_column css=”.vc_custom_1579011887505{margin-top: 0px !important;margin-bottom: 0px !important;margin-left: 0px !important;padding-top: 0px !important;padding-bottom: 0px !important;padding-left: 0px !important;}”][vc_column_text css=”.vc_custom_1727193582868{margin-top: 0px !important;margin-left: 0px !important;padding-top: 0px !important;padding-left: 0px !important;}”]<\/p>\n

Presidential Interdisciplinary Seed Grant<\/span><\/h1>\n

[\/vc_column_text][\/vc_column][\/vc_row][vc_row bg_type=”bg_color” css=”.vc_custom_1642004953070{margin-right: 0px !important;margin-bottom: 0px !important;border-right-width: 0px !important;border-bottom-width: 0px !important;padding-right: 0px !important;padding-bottom: 0px !important;}” bg_color_value=”#004e60″][vc_column width=”7\/12″ css=”.vc_custom_1707846635275{background-color: #004e60 !important;}”][vc_column_text css=”.vc_custom_1708359435941{margin-left: 10px !important;}”]<\/p>\n

Novel inhibitors targeting malaria transmission in diverse Plasmodium species<\/span><\/h4>\n

Cluster Engagement Track<\/span>[\/vc_column_text][\/vc_column][vc_column width=”5\/12″ css=”.vc_custom_1707846645685{margin-right: 0px !important;border-right-width: 0px !important;padding-right: 0px !important;background-color: #004e60 !important;}”][vc_single_image image=”963″ img_size=”full” add_caption=”yes” alignment=”right” css=”.vc_custom_1708976965745{margin-top: 0px !important;margin-right: 0px !important;margin-bottom: 0px !important;margin-left: 0px !important;border-right-width: 0px !important;padding-top: 0px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 0px !important;background-color: #ffffff !important;}”][\/vc_column][\/vc_row][vc_row][vc_column css=”.vc_custom_1595855041843{margin-top: 0px !important;padding-top: 0px !important;}”][vc_column_text][\/vc_column_text][vc_row_inner][vc_column_inner width=”2\/3″][vc_empty_space][vc_column_text]Progress in eliminating malaria, a deadly protozoan disease spread through the bite of infected Anopheles mosquitoes that infects 200 million people annually, has stalled in recent years due to the increasing ineffectiveness of long-lasting insecticide treated bed nets, (LLIN, an intervention that prevented half a billion malaria cases between 2000 and 2015). To address the critical need for novel mosquito-targeted malaria control tools, We have proposed combining insecticides on LLINs with drugs that directly target the developing malaria parasite within the mosquito, such that if a mosquito survives contact with the insecticide, it is cured of malaria, preventing onward pathogen transmission. In this project, we will expand on the initial proof of concept, to test a small panel of antimalarial drugs against the important, but understudied Plasmodium species P. vivax. As part of this project, we will build a new mathematical model of malaria transmission and use this to model the potential impact of antimalarial-impregnated LLINs across multiple established and emerging endemic settings.[\/vc_column_text][\/vc_column_inner][vc_column_inner width=”1\/3″][vc_column_text]<\/p>\n

Team Lead<\/h4>\n

Douglas Paton<\/strong>
\nDepartment of Infectious Disease
\ndpaton@uga.edu<\/a><\/p>\n

Team Members<\/h4>\n

Chester Joyner <\/strong>
\nDepartment of Infectious Diseases<\/p>\n

Pejman Rohani <\/strong>
\nOdum School of Ecology[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"featured_media":0,"menu_order":0,"template":"","format":"standard","meta":{"_links_to":"","_links_to_target":""},"categories":[],"class_list":["post-1603","projects","type-projects","status-publish","format-standard","hentry"],"_links":{"self":[{"href":"https:\/\/research.uga.edu\/team-research\/wp-json\/wp\/v2\/projects\/1603"}],"collection":[{"href":"https:\/\/research.uga.edu\/team-research\/wp-json\/wp\/v2\/projects"}],"about":[{"href":"https:\/\/research.uga.edu\/team-research\/wp-json\/wp\/v2\/types\/projects"}],"version-history":[{"count":0,"href":"https:\/\/research.uga.edu\/team-research\/wp-json\/wp\/v2\/projects\/1603\/revisions"}],"wp:attachment":[{"href":"https:\/\/research.uga.edu\/team-research\/wp-json\/wp\/v2\/media?parent=1603"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/research.uga.edu\/team-research\/wp-json\/wp\/v2\/categories?post=1603"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}