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Limited Submission: Human Immunology Project Consortium (HIPC) (U19 Clinical Trial Optional)

The purpose of this FOA is to characterize human immune responses/mechanisms elicited by vaccinations, vaccine adjuvants or natural infections by capitalizing on recent advances in immune profiling technologies.

Summary

This Funding Opportunity Announcement (FOA) for the Human Immunology Project Consortium (HIPC) solicits applications from single institutions, or consortia of institutions, to participate in a network of human immunology profiling research groups in the area of infectious diseases, including HIV. The purpose of this FOA is to characterize human immune responses/mechanisms elicited by vaccinations, vaccine adjuvants or natural infections by capitalizing on recent advances in immune profiling technologies. Studies supported under this FOA will measure the diversity and commonalities of human immune responses under a variety of conditions and longitudinally using high-throughput systems immunology approaches coupled with detailed clinical phenotyping in well-characterized human cohorts. The resulting data will be used to develop molecular signatures that define immune response profiles and identify biomarkers that correlate with the outcomes of vaccinations, vaccine adjuvants or natural infections in humans. An additional goal of this program is to promote rapid public access to HIPC-supported data and meta-data through public portals such as ImmPort.  A companion FOA will support development and operation of a HIPC Coordinating Center that will be responsible for fostering collaborations amongst HIPC-funded investigators; facilitating public dissemination of integrated HIPC findings and knowledge; and supporting development or adoption of new, robust methods for data integration, analysis, presentation, and visualization to further research and development in this field.

Please read the full program announcement before preparing your internal application.

Award Amount

  • Application budgets are limited to $1,500,000 direct costs per year.
  • The scope of the proposed project should determine the project period.  The maximum project period is 5 years.
  • NIAID intends to commit $16M in FY 2022 to fund 5-8 awards.

Eligibility

  • Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with his/her organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support.
  • For institutions/organizations proposing multiple PDs/PIs, visit the Multiple Program Director/Principal Investigator Policy and submission details in the Senior/Key Person Profile (Expanded) Component of the SF424 (R&R) Application Guide.
  • Note that the multiple PD(s)/PI(s) option may be used only for the Overall Program. Projects are limited to a single project lead per project and a single core lead per core within the multi-component application.
  • An individual can be PD/PI on only one application, including multiple PD/PI applications.   

Selection Criteria

Limitation Details

An Institution may submit one proposal.

If you are interested in submitting for this program, you must first submit an internal application to limsub@uga.edu according to the required instructions below.

Internal Applications must include the following:

  • A cover page listing
    • The name of this funding opportunity and title of your proposal
    • Your name, UGA position, home department, email, and UGA contact information
    • Collaborator names, positions, and institutions (if any)
    • Indicate whether or not you have submitted to this program in the past. If so, please provide a copy of the review at the end of the internal application.
  • A (maximum two-page) proposal summary that addresses the program’s specific selection criteria.
  • One paragraph describing why this proposal should be UGA’s submission (i.e., why it will be the most competitive for this program)
  • Curriculum vitae

Internal Selection

Limited Submission announcements often generate multiple competing proposals.  UGA reviewers judge proposals as they would in any peer review process, so PIs are urged to put their best foot forward.  Along with typical criteria, reviewers will evaluate internal proposals based on their fit with the sponsor’s articulated goals and criteria.

Internal Submission Instructions

The above internal application materials should be submitted via email as a single .PDF file to limsub@uga.edu by the internal deadline listed above.

Questions?

Please submit questions regarding the internal competition to limsub@uga.edu.

For questions directly related to this program, please contact the following program officers:

Alison Deckhut Augustine, Ph.D. – for general scientific/research questions 
Division of Allergy, Immunology and Transplantation
National Institute of Allergy and Infectious Diseases (NIAID)
Telephone: 240-627-3475
Email: NIAIDHIPCU19@mail.nih.gov

Alkis Togias, M.D. – for questions related to clinical studies/trials
Division of Allergy, Immunology and Transplantation
National Institute of Allergy and Infectious Diseases (NIAID)
Telephone: 240-627-3587
Email: NIAIDHIPCU19@mail.nih.gov

Annie Mo, Ph.D. – for general scientific/research questions
Division of Microbiology and Infectious Diseases
National Institute of Allergy and Infectious Diseases (NIAID)
Telephone: 240-627-3320
Email: NIAIDHIPCU19@mail.nih.gov

Patricia D’Souza, Ph.D. – for scientific/research questions regarding HIV studies
Division of AIDS
National Institute of Allergy and Infectious Diseases (NIAID)
Telephone: 240-627-3037
Email: NIAIDHIPCU19@mail.nih.gov


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