(OPEN) Limited Submission: Developmental Centers for AIDS Research (P30)

Summary

The purpose of this Funding Opportunity Announcement (FOA) is to invite applications for the Developmental Centers for AIDS Research (D-CFAR) program to provide administrative and shared research support to enhance HIV/AIDS research.  D-CFARs provide core facilities, expertise, resources, and services not readily obtained otherwise through more traditional funding mechanisms.  Additionally, D-CFARs provide support to assist investigators in the development of a competitive standard CFAR.  The program emphasizes interdisciplinary collaboration across all areas of HIV/AIDS research.  

Developmental Centers for AIDS Research (D-CFARs) provide support for research and administrative infrastructure, and translational HIV/AIDS research activities at institutions that receive significant HIV/AIDS funding from NIH Institutes or Centers.  The purpose of the D-CFAR is to provide support for applicants ultimately seeking a standard CFAR. A D-CFAR will allow the applicant to develop collaborations, to experiment with core facilities that may be important to support HIV/AIDS investigators at the institution, and to build and strengthen any deficiencies that might adversely affect an application for a standard CFAR award, which could ultimately lead to the development of a competitive standard CFAR application.  The emphasis expected in a D-CFAR application will be the identification and clear description of gaps or deficiencies that would hinder development of a competitive CFAR application, and Core facilities that would reduce or eliminate these gaps. D-CFARs are intended to promote NIH HIV/AIDS research efforts at the D-CFAR institution(s).  The proposed D-CFAR priorities should align with the NIH HIV/AIDS priority topics of research for support using AIDS-designated funds.

Please read the full program announcement before preparing your internal application.

Award Amount
  • Upper $750,000

A base of up to $750,000 total costs per center per year will be awarded.  The scope of the proposed project should determine the project period.  The maximum project period is 5 years. 

Eligibility
  • Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with his/her organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support.
Selection Criteria

Significance

  • Does the D-CFAR   address an important problem or a critical barrier to progress in the field? Is there a strong scientific premise for the project? If the aims of the D-CFAR   are achieved, how will scientific knowledge, technical capability, and/or clinical practice be improved? How will successful completion of the aims change the concepts, methods, technologies, treatments, services, or preventative interventions that drive this field?
  • Do the D-CFAR structure and organization enhance proposed scientific communication, outreach, synergy, and training efforts?  Does the applicant institution(s) have the necessary scientific base of HIV/AIDS investigators to warrant a D-CFAR?  Does the proposed D-CFAR application provide plans to add value to the HIV/AIDS research community at the applicant institution(s) beyond what could be expected with the pre-existing HIV/AIDS funding base?  Is there a significant need for coordination of HIV-related science at the institution(s), and will the D-CFAR serve as the primary coordinating unit for the institution(s)? Is there a high likelihood that the D-CFAR will lead to development of a competitive standard CFAR application?

Investigator(s)

  • Are the PD(s)/PI(s), collaborators, and other researchers well suited to the D-CFAR? If Early Stage Investigators or those in the early stages of independent careers, do they have appropriate experience and training? If established, have they demonstrated an ongoing record of accomplishments that have advanced their field(s)? If the project is collaborative or multi-PD/PI, do the investigators have complementary and integrated expertise; are their leadership approach, governance and organizational structure appropriate for the project?
  • Does the proposed plan for D-CFAR leadership demonstrate sufficient scientific and managerial experience, leadership skills, and time commitment to achieve success of the Center?   

Innovation

  • Does the application challenge and seek to shift current research or clinical practice paradigms by utilizing novel theoretical concepts, approaches or methodologies, instrumentation, or interventions? Are the concepts, approaches or methodologies, instrumentation, or interventions novel to one field of research or novel in a broad sense? Is a refinement, improvement, or new application of theoretical concepts, approaches or methodologies, instrumentation, or interventions proposed?
  • Does the D-CFAR adequately describe innovative ways to integrate Cores and Core services, HIV/AIDS and non-HIV/AIDS researchers, and advances in technology in order to achieve the scientific goals stated in the D-CFAR application?  Is there sufficient evidence that the D-CFAR application, as proposed, allows for innovative utilization of resources to achieve the scientific goals of all HIV/AIDS investigators at the participating institution(s)?  Will the D-CFAR strategic plans allow for changes in Core services that will meet the needs of HIV/AIDS investigators for new, rapidly emerging science?     

Approach

  • Are the overall strategy, methodology, and analyses well-reasoned and appropriate to accomplish the specific aims of the D-CFAR? Have the investigators presented strategies to ensure a robust and unbiased approach, as appropriate for the work proposed?  Are potential problems, alternative strategies, and benchmarks for success presented? If the project is in the early stages of development, will the strategy establish feasibility and will particularly risky aspects be managed? Have the investigators presented adequate plans to address relevant biological variables, such as sex, for studies in vertebrate animals or human subjects?
  • If the D-CFAR involves human subjects and/or NIH-defined clinical research, are the plans to address 1) the protection of human subjects from research risks, and 2) inclusion (or exclusion) of individuals on the basis of sex/gender, race, and ethnicity, as well as the inclusion or exclusion of children, justified in terms of the scientific goals and research strategy proposed?   
  • Has the applicant provided a comprehensive strategy to support the NIH-funded researchers at the D-CFAR institution(s)?  How robust is the plan to extend D-CFAR support to non-CFAR and investigators new to HIV/AIDS research at the D-CFAR institution(s)?  Does the D-CFAR application address gaps or deficiencies that can be overcome by having a D-CFAR to eventually be competitive for a standard CFAR? 
  • Has the applicant described the management and oversight of the D-CFAR in a manner that reflects an appreciation of the Core services end user needs and the science to be conducted at the application institution?  Does the approach create opportunities for support of novel multi-disciplinary research projects and the incorporation of investigators from different scientific disciplines to address high priority HIV/AIDS research topics?   

Environment

  • Will the scientific environment in which the work will be done contribute to the probability of success? Are the institutional support, equipment and other physical resources available to the investigators adequate for the project proposed? Will the project benefit from unique features of the scientific environment, subject populations, or collaborative arrangements?
  • Is the institutional support for the proposed D-CFAR appropriate?  Has the applicant described methods to leverage and capitalize on existing institutional resources in support of the aims of the D-CFAR?    
Limitation Details

An Institution may submit 1 proposal.

If you are interested in submitting for this program, you must first submit an internal application to limsub@uga.edu according to the required instructions below.

Internal Applications must include the following:
  • A cover page listing
    • The name of this funding opportunity and title of your proposal
    • Your name, UGA position, home department, email, and UGA contact information
    • Collaborator names, positions, and institutions (if any)
  • A (maximum two-page) proposal summary
  • One paragraph describing why this proposal should be UGA’s submission (i.e., why it will be the most competitive for this program)
  • Curriculum vitae
Internal Selection

Limited Submission announcements often generate multiple competing proposals.  UGA reviewers judge proposals as they would in any peer review process, so PIs are urged to put their best foot forward.  Along with typical criteria, reviewers will evaluate internal proposals based on their fit with the sponsor’s articulated goals and criteria.

Internal Submission Instructions

The above internal application materials should be submitted via email as a single .PDF file to limsub@uga.edu by the internal deadline listed above.

Questions?

Please submit questions regarding the internal competition to limsub@uga.edu.

For questions directly related to this program, please contact grantsinfo@nih.gov.


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