Biological Measures for Prognosing and Monitoring of Persistent Concussive Symptoms

Full title: Biological Measures for Prognosing and Monitoring of Persistent Concussive Symptoms in Early and Middle Adolescents: Center Without Walls (PCS-EMA CWOW) (U54 Clinical Trial Not Allowed)

This FOA solicits multicenter applications from multidisciplinary groups who wish to (1) discover and validate a set of objective biological measures that underlie post-injury disability and will improve accuracy for prognosticating and monitoring persistent concussive symptoms that result from concussion and/or repetitive head impacts, (2) develop a clinically useful risk stratification algorithm that incorporates these biological measures with current clinical and self-report measures (e.g., The Rivermead Postconcussive Symptom Questionnaire, Pediatric Quality of Life Inventory, or Post-Concussion Symptom Inventory for Children), and (3) provide the broader scientific community with a data resource for hypothesis generation, test validation, and discovery related to pediatric concussion using data sharing through the Federal Interagency TBI Research (FITBIR) (https://fitbir.nih.gov/) database and the NINDS biomarker repository, BioSEND (https://www.biosend.org/).

Due Date: April 10, 2019

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