The National Institutes of Health invites applications to conduct research to advance the understanding and application of synthetic biology for human health. It will support 1) the development of innovative tools and technologies in synthetic biology and 2) their application in biomedical research and human health. An integrative research plan based on collaborations of synthetic biologists with computational scientists, cell biologists, engineers, and/or physician scientists is strongly recommended. Early stage investigators in Synthetic Biology are especially encouraged to apply.
Specific topics of interest include, but are not limited to, those listed below.
- Cell-free and cell-based systems for testing and analyzing biological systems and for the efficient and scalable synthesis of complex biological products
- Cell-free (prototyping genetic circuits, discovering and evolving enzymes, and conducting biomolecular reactions)
- Cell-based (materials and pharmaceutical production, microbiome reprogramming, diagnostics)
- Natural and engineered biological circuits for implementing regulation and decision-making strategies in cells (modeling, analysis, design, and use of biological circuits, cell-cell communication, gene regulation, computation strategies)
- Expanding biochemical functionality (novel genetic alphabets, changing molecular machinery of the cell, constructing genomically recoded organisms, genetically encoded reporters)
- Advanced genome editing techniques for manipulating DNA (computational algorithms, zinc finger nucleases, TAL effector nucleases, CRISPR-Cas9)
- Design and evolution strategies to construct biological systems (directed evolution, continuous evolution, multiplexed evolution)
Standard dates apply.