{"id":43849,"date":"2022-09-28T02:00:47","date_gmt":"2022-09-28T06:00:47","guid":{"rendered":"https:\/\/research.uga.edu\/news\/?p=43849"},"modified":"2023-11-21T10:29:37","modified_gmt":"2023-11-21T15:29:37","slug":"regenerative-bioscience-team-receives-nih-support-for-tbi-research","status":"publish","type":"post","link":"https:\/\/research.uga.edu\/news\/regenerative-bioscience-team-receives-nih-support-for-tbi-research\/","title":{"rendered":"Regenerative Bioscience team receives NIH support for TBI research"},"content":{"rendered":"

Two faculty members in UGA\u2019s Regenerative Bioscience Center<\/a>, Steven Stice and Franklin West, have been awarded multiple grants from the National Institutes of Health (NIH) totaling $1.1 million to study potential treatments for traumatic brain injury.<\/p>\n

Over the next two years, Stice<\/a> and West<\/a> will collaborate with MRI expert Qun Zhao<\/a>, professor of physics in the Franklin College of Arts & Sciences<\/a>, to evaluate and better understand the brain\u2019s functional organization and neural repair of networks following traumatic brain injury (TBI).<\/p>\n

TBI is a universal health concern and has been called a \u201csilent epidemic,\u201d as many patients are not aware they are suffering lasting damaging from injury. Each year in the United States, 2.5 million patients visit the emergency department after suffering a TBI. Of those millions, 56,800 die and more than 288,000 require hospitalization, rehabilitation programs or long-term supportive care.<\/p>\n

According to the team, approximately 25% of moderate to severe TBI patients show a high degree of spontaneous recovery that cannot be explained. Studies have also shown that, even without rehabilitation, some recovery of function typically occurs following a TBI. One of the two NIH grants will support research using image analysis to evaluate the phenomenon of spontaneous recovery.<\/p>\n

The second NIH grant will support further research into the capabilities of a proprietary neural exosome product, AB126\u2122 to assess the safety, dosage, efficacy and quality of the product to potentially treat TBI.<\/p>\n

\u201cBy studying the disease state of TBI and the limitations of brain repair in swine models, we will be able to determine whether a new approach works effectively in humans and is safe,\u201d said West, professor of animal and dairy science in the College of Agricultural and Environmental Sciences<\/a>.<\/p>\n

The team plans to access technology and intellectual property that emerged from UGA research and spinout Aruna Bio<\/a>, <\/strong>a biotechnology company that develops nanomedicine platforms for neurodegenerative disease and injury such as Parkinson\u2019s, stroke and TBI.<\/p>\n

\u00a0<\/strong>Presently there are no neuroprotective or regenerative Food and Drug Administration (FDA) approved TBI treatments.<\/p>\n

AB126\u2122, licensed by Aruna Bio, could become the first FDA-approved, TBI-targeted delivery system to modulate or bypass the blood brain-barrier and enhance the body\u2019s ability to self-repair. AB126\u2122 is derived from a proprietary neural stem cell line and carries anti-inflammatory and neuroregenerative cargo to ultimately slow and\/or stabilize the progression of TBI.<\/p>\n

Stice, a Georgia Research Alliance Eminent Scholar in Regenerative Medicine, is co-founder and chief scientific officer at Aruna Bio. He said the NIH grants will help accelerate the company\u2019s timeline for future clinical trials.<\/p>\n

\u201cThe NIH funding will help the company accelerate the development phase for pre-clinical trial modeling and safety, particularly the probability of the trial\u2019s success,\u201d Stice said.<\/p>\n","protected":false},"excerpt":{"rendered":"

Two faculty members in UGA\u2019s Regenerative Bioscience Center, Steven Stice and Franklin West, have been awarded multiple grants from the National Institutes of Health (NIH) totaling $1.1 million to study potential treatments for traumatic brain injury. Over the next two years, Stice and West will collaborate with MRI expert Qun Zhao, professor of physics in … <\/p>\n

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